Spurred rye; Ergot of rye.

The fungus Claviceps purpurea , Tulasne, is the cause of this disease in rye (and in other grasses), see Lolium. Moisture favors the development of this fungus; epidemics, known as Raphania, Kriebelkrankheit, etc., are traced to the use of rye flour poisoned by this fungus.

Preparation for use, Tincture.

Authorities. (Nos.

1 to 80 , from Trink's collection, Hartlaub and Trinks, Annalen der Hom. Klinik, 3, 228).

1 , Caspar Schwenkfeld, Theriotrophæum Silesiacum, Lignit, 1604, giebt die erste Nachricht von dem Vorkornum der Kriebelkrankheit; 2 , Barbeck, de morbis convulsis. Duisb., 1763, 4; 3 , Perrault, Lettre de Dodart in Journ. des Savans, ann. 1676, T. IV, p. 79; 4 , Thulier, in Journ. des Savans, ann. 1676, T. IV, p. 79; 5 , May, Bericht, wie die sich ereigwende Grimmund Krampfsucht zu kuriren. Kassel, 1683, 4; 6 , Fr. Hoffman, med. rat. system, T. II, p. 300; 7 , Geoffroy, Tractatus de Mater. med. Venet., 1665, T. II, p. 2; 8 , Wepfer, Eph. Nat. Cur. Dec., III, Ann. II, p. 300; 9 , J. Scheuchzer, Miscell. Lips, T. V; 10 , J. H. Hoffmayer, Sendschreiben von der bisher an vielen Personen in seiner Gegend gefundenen Kiebelkrankheit, krummen, oder schweren Nothkrankheit, deren Ursachen und Heilmitteln, Berlin, 1702, 8; 11 , Mémoires de l'Académie de Paris, 1710; 12 , Lang, descriptio morborum ex clavorum secalinorum usu, etc., Lucern, 1717, 8; 13 , W. H. Waldschmidt, de morbo epidemico, per Holsatium grassante, Kilon, 1717, 8; 14 , Haberkorn, unvorgreifliche Gedanken von der Ziehe--oder Nervenkrankheit, welche durch das inficirte Korn in Sachsen und der Lansitz eingerissen, Budissin, 1717, 8; 15 , G. Budæi., consilium medicum von d Krampfkrankheit, Budissin, 1717, 8; 16 , G. W. Wedel, de morbo spasmod. epidem. maligno in Saxonia, Lusatia, etc., Jenæ, 1717, 4; 17 , J. D. Longolii, judicum medicum de corruptione lymphæ per frumentum corruptum, oder medic. Gedanken von der Kronstaupe, welche ann., 1716-17, an verschiedenen Orten in Sachsen unter dem Titel des Reissens und der Ziehkrankheit, etc., bekannt. S. k., 1717, 8; 18 , C. G. Wilisch, Bericht von der Krampfsucht, oder spasmod. Krankheit, so an verscheid. Orten im vergang. Jahre sich ereignet., Pirna, 1718; 19 , Breslauer Sammlung von Natur-, Medicin-, Kunst- und Literatur-geschichte, I, II, Vers., 1718; 20 , G. Schober, epitome diss. med. de sem. loliac. et secalis nigri corrupt., cum farina commixt. et alimenti loco assumtis varios morb. epid. ann. 1722, etc., producent. in Act. Cand. Lips., 1723; 21 , C. Vater, observationes selectæ de morbo spasmod. popillari Silesiaco. Viteberg. 1723; 22 , Noel, in Histoire de l'Acad. des Scienc. ann. 1710, page 80; 23 , Fontenelle, in Histoire de l'Acad. des Scienc. ann. 1710, p. 81; 24 , H. Ludolf, diss. sistens casum novi morbi spasm. convuls. vulgo dicti: Steifenfuss, steife Krankheit, Krampfsucht, ziehende Seuche, Grübelkrankheit, Erford, 1727, 4; 25 , ---, diss. de affectu spasm. vago maligno epidem. vernac. Grübelkrankheit, Erford, 1756, 4; 26 , F. E. Brüchmann, relatio de clavis secal. morbor. inde exort. epidem., quem die Kriebelkrankheit vocant, etc., in Comment. lit. Novimb., 1734, heb. VII, Nr. III; 27 , C. A. Bergen, dissert. de morbo epidem. convulsivo, contagii experte. Francofurt. ad Viadr., 1742, 4, auch in Haller, Samml. prakt. Streitschriften, B. I, p. 87; 28 , Rosén a Rosenstein, diss. de morbo spasmod. convulsivo epidem. Goth, 1749, 4; 29 , Cothenius, Nachricht von der Schädlickheit des Mutterkornes in Schreber's Samml. verschied. Schriften. halle, 1756, 8, Th. II, p. 413; 30 , P. J. Bergic, diss. de epilepsia acuta epidemica, Holm, 1756, Mater. Med. e regno veget. T. I., p. 49, obs. VI; 31 , Tissot, epistola ad D. G. Baker, de morbis ex usu secalis cornuti, data Lausannæ, 1764, anmehren Orten in's Deutsche uebersetzt; 32 , Müller, in Act. med. Berol. Dec., II, vol. vi, p. 50; 33 , Burkhardt, in Satyr. med. Siles. Spec., III, Obs. IV; 34 , Ant. Scrinc, in Satyr. med. Siles. Spec., IV, Obs. V, p. 35; 35 , Salerne, Mémoire sur les maladies que cause le seigle ergoté in d. Mém. de Math. et de Phys. de l'Acad., T. II, p. 155; 36 , Dodart, im Journal des Savans, 1769, ch. 16, Mars.; 37 , Linné, Diss. de Raphania, Upsal., 1763, 4; 38 , Sauvages, Nosol. Method. Amstelod., 1763, T. III, P. I, p. 547; 39 , Th. Aug. Schleger, Versuche mit d. Mutterkorne, Cassel, 1770, 4; 40 , M. Vetillart, Mémoire sur une espèce de poison sous le nom d'argot, seigle, ergotés, blé cornu, mane, etc., Tours, 1778; 41 , Du Bourrix, Mémoire sur la nature et les effets du seigle ergoté, pour servis de réfutation au mémoire de M. Schleger, Paris, 1771; 42 , Wichmann, Beiträge zur Geschichte der Kriebelkrankheit im J., 1770, Leipz. u. Zelle, 1771, 8; 43 , Vogel, Schutzschrift für das Mutterkorn, als einer angelblichen Ursache der Kriebelkrankheit, Götting., 1771, 8; 44 , Leidenfrost, diss. de morbo convuls. epidem. Germanorem, caritatis annonæ comite, vulgo; die Kriebelkrankheit, Duisburg, 1771, 4, und in Baldinger's Magazin, 1776, St. IV; 45 , L. E. Eschenbach, Bedenken vor der Schädlichkeit des Mutterkornes, Rostock, 1771, 8; 46 , Baldinger, Programma ad diss. de metastasi in morbis, præfatio docet, secale cornutum perperama nonnullis ab infamia liberari, Jenæ, 1771, 4; 47 , Taube, Geschichte der Kriebelkrankheit, besonders derjenigen, welche in d. Jahren, 1770, u. 71, in den Zellischen Gegenden gewüthet hat. Gott., 1782, 8; 48 , Marcard, von einer der Kriebelkrankheit ahnlichen Krampfsucht, die in Stade beobachtet ist., Hamburg, 1772, 8; 49 , Focken, Versuche, Beobachtungen, Erfahrungen und Kurarten in d. sogenannten Kriebelsucht, Zelle, 1771, 8; 50 , C. L. Nebel, diss. de Secale cornuto, ejusque noxa, experientia atque experimentis chemic. nixa., Giess, 1771, 4; 51 , Ejusdem Progr. quo diss. suam de Secali cornuto a noxiis ac temerariis et contumeliosis objectionibus Schlegeri vindicat, Giess, 1772, 4; 52 , B. W. Roeder, gründliche Abhandlung von der in Deutschland hin und wieder grassirenden Seuche, die Kriebelkrankheit oder Krampfsucht genannt, worin deren Beschaffenheit, Ursachen, Vorbauung und Heilung beschrieben, Frankf. und Leipzig, 1772, 8; 53 , J. L. Herrmann, Abhandl. u. gegründ. Wahrnehm. von der Kriebelkrankheit, so in Niederschlesien, 1771, u. 72, epidem. grassirt hat, Kassel, 1774, 8; 54 , Read, Traité sur le seigle ergoté, Strasbourg, 1771, 12; 55 , Tessier, Traité de maladies des grains, Paris, 1783, 8; 56 , ---, Mémoire sur les observat. faites en Sologne en 1772, in Mém. de la soc. roy. de Méd., A. 1776, p. 417; 57 , Sangiorgio, diss. sur la gramigna che nella Lombardo infesta la segala, Milan, 1772; 58 , C. L. E. Hartmann, Berichte und Bedenken, die Kriebelkrankheit betreffend, etc., Kopenhag., 1772; 59 , Berichte und Bedenken, welche von den schleswigholstein, Physicis and d. kön. d. Kammer zu Kopenhagen sind gesandt worden, nebst d. Respons. des k. Coll. med., und ein Unterricht für d. Landvolk, Kopenhag., 1774, 8; 60 , G. M. Brawe, Beiträge zur Geschichte der Kriebelkrankheit im Jahre 1771, Bremen, 1772; 61 , Dreyssig, Handbuch d. med. Diagnost. Bd., 2; 62 , Haase, Handbuch der chron. Krankheiten, T. II; 63 , Jahn, Klinik d. chron. Krankheiten, T. I, p. 253; 64 , Richter, Spec. Therap., T. IV; 65 , Haller, Mat. med, übers. von Vicat. T. II; 66 , Spielmann, Institut. mat. med.; 67 , Keyl, Diss. de Secali corn. ejusque vi in corp. human. salubri et noxia, Berolin, 1823, 8; 68 , C. Knape, über die zweckmäss. Schutzmittel gegen d. nachtheil. Wirk. des Mutterkornes, in Hecker's Jahrb. d. St. A. I. B. 2, Th. p. 240; 69 , J. C. Lorinser, Versuche u. Beobacht. üb. die Wirk. des Mutterkornes auf d. menschl. u. thier. Körper, Berlin, 1824, 8; 70 , Henning; 71 , Waghas; 72 , Nolten; 73 , Class; 74 , Evers Taube; 75 , Œltze; 76 , Osswald; 77 , Roemhild bei Lorinser; 78 , Cordier bei Froriep; 79 , Uensler; 80 , Acta Eruditor; 81 , Bigelow, N. E. Med. J., 1816, p. 162, effects in seven cases, from doses of over a scruple; 82 , Wessener, Hufel. J., 1817, effects of eating rye bread poisoned with it; 83 , Villeneuve, A. H. Z., 1, 131, Histoire sur Secale Cornut., Paris, 1827, general effects; 84 , Hartmann, A. H. Z., 1, 27, symptoms; 85 , Perrotton, Hirschel's Archiv, 1, 156, effects of large doses, in labor; 86 , Puchstein, Hirschel's Archiv, 1, 235, effects of "ergot bread;" 87 , same, in a man; 88 , Lorenz, A. H. Z., 1, 131, general effects; 89 , Wagner, A. H. Z., 1, 129, from Hufel. J., 1832, epidemic poisoning; 90 , Swett, Bost. M. and S. J., 1834, p. 420, general effects; 91 , Munsell, Lond. Med. Gaz., 14, 605, a woman in fourth month of pregnancy took a drachm; 92 , same, another woman took a drachm in two doses; 93 , same, a woman in labor took 2 drachms in two doses; 94 , Hooker, Bost. M. and S. J., 10, 299, a man took 1/2 drachm of the light oil at 2 P.M., and 1 drachm at 3 and 4 P.M., also another man experienced the same effects from 40 minims; 95 , same cases, the symptoms that continued apparent for a week; 96 , same, a man took 14 ounces of infusion, and another man 8 ounces within two hours; 97 , Hulse, N. A. Archives of Med. and Surg. Sc., 1835, p. 81, a woman, just delivered, suffering from hæmorrhage, took 12 ounces of infusion in doses, every half hour; 98 , Jacoby, Archiv. de Méd. Strasbourg, 1835, effects of drachm doses of powder during pregnancy; 99 , Thompson, Lancet, 1836-7, p. 854, effects; 100 , Schramm, Berlin Kl. Wach., 1837, p. 378 (from Helbig Heraclides, 1, 56); 101 , Roullin, Froriep, Notizen, 1829 (from Helbig); 102 , Jansen, Rust's Mag., 1829 (ibid.); 103 , Cottmann, Am. Med. Intell., 3, 329, experiments on healthy lunatics, with scruple and 1/2-drachm doses; 104 , Beckwith, Am. Med. Intell., 3, 213, a woman in labor took 30 grains; 105 , Allier, Bull. de Thérap. (Am. J. of Med. Sc., 25, 210), effects in cases suffering from paralysis of the bladder; 106 , Ann. de Méd., 1, 839, effects in a healthy man, of 24 grains; 107 , Chavasse, Transact. Prov. M. and S. Assoc., 4, injurious effects; 108 , De Gravina, Annali Univers di Med., 1839 (Br. and F. Med.-Chir. Rev., 1840), the author took 24 grains; 109 , Jablanczy, A. H. Z., 30, 295, provings on self, with a dose of 50 drops of tincture; 110 , same, on Mr. Matzeka; 111 , Maisonneuve, Gaz. des Hôp., 18, 711; 112 , Barbier, Recherches sur Secale (A. H. Z., 20, 143), a person took several drachms; 113 , Wright, Edin. M. and S. J., 1840, p. 9, effects of a dose of 2 1/2 drachms; 114 , same, a woman, flooding, took 1/2 drachm three times a day for a fortnight, then 1 drachm four or five times a day for five days; 115 , same, a woman in labor, took an infusion of 2 drachms; 116 , Holt, Lancet, 1842-3, 1, 712, effects on infant, when administered to mother during labor; 117 , Cotlet, Edin. M. and S. J., 1842, 1, 83, effects of 1/2 drachm, repeated in twenty minutes, in a woman in labor; 118 , Med. Times, 1843, 419, effects of 3 drachms, in a woman with cancer of neck of uterus; 119 , Bost. M. and S. J., 1843, 168, from Gaz. des Hôp. dysentery in twenty-seven persons, caused by eating diseased rye; 120 , Gibbon, Am. J. of Med. Sc., 33, p. 244, 1844, a healthy man took 16 grains of powder in a decoction; 120 a , same, took a scruple in a decoction; 120 b , same, 1 drachm; 121 , Gibbons, took aq. ext., 10 grains; 121 a , same, took 30 drops of the ethereal oil; 122 , Parola, Gaz. Med., 1844, No. 19, effects of 30 grains (symptoms after two hours); 123 , same, experiment on self with 20 grains; 124 , Patze, Med. Zeit. Preuss., 1844 (Br. J. of Hom., 3), effects of a drachm of powder; 125 , Pardu, Annali Univers di Med., 1844, effects of 30 grains, in a man suffering from a trifling disorder; 125 a , same, repeated with same and additional symptoms; 126 , same, another in health took 20 grains of powder; 126 a , same, took 30 grains, after a hearty meal; 127 , Med. Zeit. Preuss., 1845, a man took a drachm of powder; 127 a , same, repeated; 127 b , same, 2 drachms; 128 , same, another man took a drachm; 128 a , same, repeated; 128 b , same, took 2 drachms; 129 , Ker, Br. J. of Hom., 8, 462, effects; 130 , Arnal, Mem. Royal. Acad. de Méd., 1849, experiment on self, took 1 1/2 drachms of powder, kept quiet, and counted his pulse every fifteen minutes; 130 a , same, another experiment; 131 , Nuttal, Med. Times, vol. 16, p. 391, effects of eating poisoned bread; 132 , Œst. Med. Woch., 1847, No. 42, effects of poisoned bread; 133 , Bonjean, Lancet, 1845, 1, 701, a family poisoned by bread; 134 , Pratschke, Casp. Woch. (Lond. Med. Gaz., 1850, p. 579), poisoning of a woman by bread; 135 , same, a girl aged eighteen; 136 , same, a girl aged seven; 137 , same, child aged four; 138 , Ungefug and Strahler, Zeit. Verein Œst., 2, 252, ergotismus, in a boy; 139 , same, in a man; 140 , Huss-busch, Frank's Mag., 4, 687, cases of ergotismus; 141 , same, effects of a teaspoonful taken to produce abortion; 142 , Hussa, Vjs. Prag., 1856 (A. H. Z., 52, 167), poisoning of three persons by flour, one sixth ergot; 143 , same, in a boy; 144 , same, in a girl; 145 , Heusinger, Deutsch Klin., 1856, epidemic ergotismus; 146 , Zabari, Œst. Zeit. f. ver. Ærzte, 1, 117, effects of poisonous bread, in a child; 147 , same, in a woman; 148 , Dietz, Zeit. f. ver. Ærtze Œst., 2, 252, effects of 2 drachms; 149 , Channing, Bost. M. and S. J., 1859, p. 138, effects of quarter of a pound, in a pregnant woman; 150 , Meyer, Wien Wochbl., 1861, epidemic of ergotismus; 151 , Neubert, Journ. of Pharmacod., 2, 4, a woman poisoned; 152 , Ricker, Nass. Med. Jahrb., 15, 748, a family poisoned by bread; 153 , Casp. Vjs., 20, 1862, effects of large doses, in a woman; 154 , Poyet, Annal. de Soc. de Méd. de St. Étienne et de la Loire, 1863, effects of ergoted bread; 155 , Hill, Trans. N. Y. Hom. Med. Soc., 2, 214, effects of 1/2 an ounce of powder, in a woman suffering from continued menstruation, death on eleventh day; 156 , same, from N. O. Journ. of Med., a woman six months pregnant took powder of ergot, 40 grains every half hour, for about two hours; 156 a , same case, two days later, took 3/4 of an ounce in six hours; 157 , Stephens, Brit. Med. Journ., 1864, p. 503, fatal effects of tincture, taken to produce abortion; 158 and 159 , omitted; 160 , Flinzer, Vjs. f. ger. Med., 8 (1869), a boy poisoned by bread; 161 , same, another boy; 162 , a girl, aged sixteen; 163 , same, a woman; 164 , same, a girl, aged twenty-two; 165 , Possart, Am. Obs., 6, 21, effects of poisonous doses; 166 , Dr. G. S. Oldright, Canada Med. Journ., 6, 404, effects of ergot administered three days after delivery for slight flooding; 167 , Nicol, Br. and F. Med.-Chir. Rev., 1872, 2, 203, effects of drachm and 1/2-drachm doses of fluid extract; 168 , Heuschel, Med. Rec., 9, 471, an infant, born about the eighth month, received by mistake, 30 drops of Squibb's fluid extract; 169 , Wernich, Einige Versuche ueber das Mutterkorn, Berlin, 1874, effects of a large amount, in a woman three months pregnant; 170 , Smith. Pharm J., 1874, p. 622, effects of 3 to 7-grain doses.

MIND

Delirium, 20, 91, 161.*
Delirium; she abandons her relatives and does absurd things, 42.
Delirium; he makes no answer (in a child eight years old), 42.
Muttering delirium, very restless, agitated, and fearful of death (first day), 155.
Muttering delirium (in six hours), 93.
Delirium with violence, 37.
Confusion of mind, with delirium bordering on mania; every patient raved and could be restrained only with great difficulty; followed after some hours by violent involuntary vomiting, and by continued deep sleep; after this there remained excessive vertigo, as after intoxication, with a feeling of exhaustion and powerlessness, 72.
Rage, 165.
Raving, 32, 34 , etc. [10.]
Raving, with an attempt to jump into the water, 71.
Raving, so that she must be restrained, 73.
In two hours delirium came on, succeeded by heavy sleep and snoring. She could be roused, not to consciousness, but to low muttering, wanderings, 104.
Extreme excitement, with wild look and impaired vision, 98.
Excited and confused, 166.
Transient delirium with the headache (second and third days), 156a.
Slight attacks of delirium, 64.
Mild delirium, 64.
A considerable degree of exhilaration, with preternatural wakefulness, both of them lying awake, with a very pleasant train of sensations and thoughts, through nearly the whole succeeding night, 96.
Sensorium disturbed in the night; could not get rid of the impression that there were two sick persons in the bed, one of whom recovered and the other did not (fifth night), 155. [20.]
She was conscious, but the room presented to her the impression of water excessively agitated on its surface. She could compare it only to the "foaming of a troubled sea," 115.
Illusions of sense, 62, 145.
Imbecility, .

HEAD

Confusion and Vertigo.
Confusion of the head, 64.
Confused feeling in the head, 170.
*Vertigo, 20, 64, 70, 71, 76 , etc. [80.]
Chronic vertigo, 142.
Vertigo and reeling, so that the patients could not stand upon their feet, 100.
Vertigo and reeling as if intoxicated, 100.
Vertigo for twenty-four hours after a dose, 84.
Reeling as from intoxication, 34.
Vertigo, that often lasts more than a month, sometimes disappearing for a short time, at other times more violent than ever, especially after eating bread, 72.
Constantly increasing vertigo, 34.
Vertigo, 74 . [Caused by the odor of the fungus in the meal.]
Vertigo (after half an hour), lasting twelve to twenty hours, and even obliging the patient to remain in bed several days, 75.
Vertigo and stupefaction, 61, 70. [90.]
Vertigo and heaviness of the head, 34.
Reeling, with inability to stand upright, 75.
Dizziness and weakness (after two hours), 166.
Dizziness of the head, on moving (sixth and seventh days), 135.
Head dizzy and heavy (ninth day), 155.
Dizziness and heaviness of head (tenth day), 155.
Giddiness and whirling of the head (tenth day), 155.
Could scarcely walk, owing to the giddiness which had succeeded to the confusion of the head (fourth day), 124.
Giddiness and sensation as if about to fall, on the slightest movement (first day), 155.
Intoxication, 22, 65, 75.
General Head. [100.]
Pendulum-like movements of the head, 147.

EYE

After the epidemic an unusually large number of cataracts occurred in young people, twenty-three of whom gradually became blind (fifteen men and eight women), associated with headache, vertigo, and roaring in the ears; of the cataracts two were hard, twelve soft, and nine mixed, 150 . [Out of 283 persons attacked, 198 died.]
*Eyes sunken and surrounded with a blue margin (fifth day), 156.
*Eyes lay deep in the head (fourth day), 124.
Eyes staring and wild, with dilatation of pupils (second day), 135.
Eyes wild and distorted, with pupils much dilated (first and second days), 155.
*Staring look, 139.
Wild staring look; face red; inarticulate moans and movements of the head to and fro; arms rigid and immovable the hands drawn over to the chest, 87.
Eyes wild, distorted, 42. [150.]
Staring and blindness, 37.
Spasmodic distortion of the eyes, 63.
Fixedness of the eye (soon after second dose), 117.
Glistening eyes, 83.
Right disk decidedly paler, with retina also of a paler tint. Left also paler (in one hour). Right disk paler; on apparent inner side decidedly; on outer side also a little. Left eye altogether a little paler (in one hour and twenty minutes). Retina and disks of both eyes decidedly pale, and this is especially observable in the right eye (in one hour). Retinæ not quite so pale; disks the same as before (in one hour and a half), 167.
Eyes very yellow (sixth day), 155.
Rolling of the eyes about the orbits, 64.
Squinting, 64.
Light painful to the eyes (eleventh day), 155.
Pain in the eyes (first day), 156a.
Conjunctiva. [160.]
Conjunctiva and sclerotic coat yellow and injected (second day); conjunctiva bright yellow (fifth day), 155.
Ball.

EAR

Sensation as if the ears were stopped, 110.
Roaring in the ears, with great difficulty of hearing, 61.*
Roaring in the ears, 62, 84, 145.* [200.]
Difficulty of hearing, 70, 84.
Hearing impaired (fourth day), 124.
Transient deafness with insensibility of the fingers of the whole hand; frequent falling asleep of the limbs, 48.
Deafness (soon after second dose), 117.*

NOSE

*Constant nosebleed, 12.
*Nosebleed, 28, 64 ; (fourth day), 124 ; (eleventh day), 135.
Hæmorrhage from the nose (third day); worse than before (fourth day); epistaxis (fifth day), 155.*
Dryness of the nasal mucous membrane, 139.
Olfactory nerves very sensitive (tenth day), 155.

FACE

Shortly the palpebræ began to swell, likewise the lips and fauces; the tears flowed copiously; the Schneiderian membrane seemed much stimulated, and there was coryza, great difficulty of breathing through the nose, and injection of the vessels of the conjunctiva. The lips and palpebræ began to puff, as if stung by a bee, and gradually assumed a livid appearance. The power of deglutition was nearly lost; the voice became feeble; she said her jaws were fixed, and shortly after it was with greatest difficulty that an answer of yes or no could be elicited. Previous to arriving at this point, she had complained of pain in every nerve, and a sensation of emptiness of the head, 97. [210.]
The face and head suddenly became intensely congested, being of a purplish-red color, after stimulants and warmth were applied, 166.
Face and abdomen swollen, 32.
Face puffy, 98.
Face sunken, often discolored, 47.
*Features sunken, 64.
*Face drawn, 142.
Risus sardonicus, 165.*
Suffering expression, 48.
Face hippocratic, discolored, 61.
Stupidity of expression (soon after second dose), 117. [220.]
Countenance had a remarkably heavy idiotic expression (after second dose), 94.
*Expression of face most anxious, 157.
Face pale and haggard, 138.
*Face pale and collapsed (next morning); ashy (fourth day), 124.
*Face pale, 122, 125, 151, 153.
*Face very pale, 108.
*Face pale, sunken, hippocratic, 64.
Transitory paleness (in one hour), 167.
Face flushed and livid at times (first day), .

MOUTH

Teeth.
Gnashing of the teeth, 64.
The teeth became loose and fell out, 101.
Bloody sordes (tenth day), 155.
Sordes on the teeth (seventh, eighth, and ninth days), 135.
Toothache, to which he had been subject, on exposure to cold (after one hour), 126a.
Tongue.
The patient frequently bites the tongue, 61.
The tongue is often torn during the most violent convulsions, 34. [250.]
Tongue a good deal swollen (second day), 104.
Twitching and swelling of the tongue, with a suffocated voice and a constant flow of saliva, 34.
Tongue heavy, tremulous, white, difficult to protrude between the teeth, so that speech was almost unintelligible, 100.
Tongue dry, scarlet at the edges, crimson and black in the middle (second and third days), 156a.
Tongue white, 138.*
Tongue white and moist, 135.
Tongue heavily coated white at noon, dry and brown at the tip (first day); coated with a heavy brown fur and pointed at the end (second day); heavily coated with a brownish fur, dry at the tip, edges stiff and swollen (third day); dry and brown (fourth day); dry, brown at the tip, and lead-colored at the root (fifth day); covered with a brownish lead-colored coat in the centre, red at tip and edges (sixth day); clean, very dry, and red at the tip (seventh day); dry, glazed, and stiff, appearing as if baked, to the touch, with a hard crust formed on the surface (eighth day); clear, red, and somewhat more moist than last night, pointed at tip (ninth day); red and dry (tenth day); red, dry, cracked, and bleeding (eleventh day), 155.
Tongue covered with a whitish-yellow, dry, thick coating (next morning), 124.
Tongue discolored brown, and at last quite black, 64.
Tongue covered with mucus, 64. [260.]
Tongue clean, 42.*
Prickling in the tongue, 84.
The tongue was often terribly bruised and bitten, .

THROAT. [300.]

Hawking up of tenacious mucus, with pressive pain in the right tonsil, 109.
Dryness in the throat, 138, 152, 170.*
Great dryness and irritation of the throat, which was intensely injected with blood, and on the left side of the soft palate was a dark patch looking as if blood was effused beneath the mucous membrane, 157.
Throat sore, with difficulty of swallowing, at 10 A.M.; œsophagitis; inability to swallow while lying down, at 8 P.M. (second day); not as sore (third day), 155.
Soreness and tightness about the throat (second day), 204.
Violent burning in the throat, 84.
Intolerable crawling in the throat, 48.
Burning in the fauces and along the œsophagus to the stomach (second and third days), 156a.

STOMACH

Appetite.
Excessive appetite; ate enormously of whatever was given him, 32.*
Very great appetite in girls, two, five, and eight years old, 70. [310.]
Ravenous appetite, 86.*
Insatiable appetite, 77, 82.*
Unusually great appetite, 70.
*Unnatural appetite, even when dying from exhausting discharges from the bowels, 35.
Increased appetite, 84.
Ravenous hunger, with improvement after eating, 106.
Ravenous hunger, 138.*
Constant ravenous hunger after the spasms, special desire for bread, 142.
A kind of ravenous hunger and mental weakness for a long time, 76.
Greediness; anything satisfied him; constant longing for food, 139. [320.]
Extreme greediness, especially for acids, 47.
Patients eat a great deal without being nourished, 32.
Bulimia, 34.
Increased hunger, 76.
Desire to eat through the whole illness, 42.
The appetite is either natural or ravenous, 61.
Ate more than usual (second day), 124.
Appetite moderately increased, 64.
Loss of appetite, 90, 95, 100 , etc.
Great aversion and inclination to vomit (after two hours), 69. [330.]
Aversion to food, 64, 84.
Complete disgust for food, with an occasional feeling of coldness at the stomach that thence pervaded the whole frame, 108.
Loathing of food and drink (tenth day), 155.
Anorexia, for two days, .

ABDOMEN

Hypochondria.
Tenderness in the right hypochondriac region (ninth day), 155.
Pain in liver, stomach, and bowels (tenth day), 155. [440.]
Torpidity of the liver (tenth day), 155.
General Abdomen.
Abdomen tympanitic (first and fifth days), 155.*
Meteorismus, 64.*
Abdomen tense, 146.
Abdomen distended, 42.*
Abdomen very soft, 135.
Abdomen hard, tense, painful to touch, 42.
Soreness, bloating, and rumbling of wind in the bowels (seventh day), 155.
Rumbling of wind in the bowels (fifth day), 155.
Borborygmi (after two hours), 130. [450.]
Convulsive colic, 63.
Violent colic, 77.
Colic, 76, 113 ; (after two hours), 130.*
Griping pains accompanied stools, 166.
Complained urgently of abdominal and epigastric pain, 151.
Severe paroxysms of abdominal pains, recurring every fifteen minutes, and lasting hardly sixty seconds (after one hour), 168.
Abdominal pain, 170.
Pain and soreness in the bowels (seventh day), 155.
Patient describes the pains in the bowels as if a hundred knives were drawn through the parts down to the womb, ovaries, urethra, and vulva (eighth day), 155.
Severe pain in abdomen, which was swollen, tense, and exquisitely tender, 149. [460.]
Pain in the abdomen and burning in the stomach, 153.*
Painful contractions in the upper abdomen (after one hour), 123.
Spasmodic tension of the abdomen, .

RECTUM AND ANUS

Paralysis of rectum (tenth day), 155.*
Anus stood wide open, 87.*
Stinging-cutting pains in the rectum; great irritability of the sphincter ani, with spasms (ninth day), 155.
Severe cutting pain in the rectum (tenth day), 155. [480.]
Pain and spasm in rectum (tenth day), 155.
Excruciating pain in hæmorrhoidal veins (tenth day), 155.
Distressing itching in the anus, 110.
Frequent ineffectual efforts for stool, 47.
Urging to stool, with pressive pain in the abdomen, relieved after a normal evacuation, in the morning (second day), 109.
Ineffectual desire for stool, 153.

STOOL

*Diarrhœa, 32, 47, 50 , etc.
Diarrhœa, lasting from five to fourteen days, very exhausting, 42.*
Very offensive diarrhœa, 64.*
Pernicious diarrhœa, 64.* [490.]
Diarrhœa; frequent, brown, and slimy discharges from the bowels (first day); diarrhœa continued, discharges from the bowels very fetid, and dark-colored (second day), 155.*
Diarrhœa; the stools were of a dark-gray color, looked as though meal had been stirred through them, and had a peculiar sickly indescribable odor, 166.
Sharp diarrhœa (after four hours); this yielded to repeated hot baths; but for two weeks there was constant tendency to diarrhœa, 168.
Three or four hours after the chill, spontaneous diarrhœa commenced, continuing five or six hours, 156.
Thin involuntary discharges from the bowels, 62.*
*Stool thin, olive green , for the second time in the forenoon, without colic, followed by persistent burning extending, high up in the rectum, itching in the anus, making him almost beside himself (second day), 109.
Stool at first mucus, afterwards bilious or sanguinolent, 119.
Discharges from the bowels of a great quantity of disorganized mucous membrane, resembling that thrown off in dysentery (eighth day); movement from the bowels of watery feculent matter (eleventh day), 155.
Hæmorrhage from the bowels (ninth day), 155.*
Hæmorrhage from the bowels (tenth day); hæmorrhage; the blood does not clot, and is very thin and almost black (eleventh day), 155.* [500.]
Evacuation of worms, 47 ; in children, 48.
Motion of the bowels for the first time since taking the Secale (fourth day), 124.
Constipation, , , , .*

URINARY ORGANS

Great sensitiveness of the bladder and ovarian region (sixth day), 155.
Paralysis of bladder (tenth day), 155.*
Spasm of meatus urinarius (ninth day), 155.
Cutting pain and smarting in the urethra, as if a knife were drawn through the parts, when attempting to urinate (fifth day), 155.
Burning in the urethra during micturition, 84.
Frequent desire to urinate, though not without effort, 84.
Violent but ineffectual urging to urinate, 153. [510.]
Obliged to urinate at night, contrary to habit, also no desire to urinate, in the morning, yet a large quantity of clear urine was vigorously passed during stool, 109.
Copious micturition, 115.
Involuntary micturition, 87.
Micturition difficult, with constant desire in the bladder, 42.
Micturition seldom, dribbling and without relief, 47.
Retention of urine, 145.
Inability to pass water, 151.
Increased discharge of urine, 84, 146, 147.
Frequent and pretty copious discharges of urine (after second dose), 94.
Urine somewhat increased (after two hours), 130. [520.]
Urine scanty and dark-colored (first day); urinary discharges of a dark wine, or "prune-juice" color (second day); suppressed; on introducing the catheter, about a gill of dark prune-colored urine passed, which appeared to be full of gritty sediment, and emitted a very disagreeable odor (third day); suppressed but on using the catheter, about a teaspoonful escaped, which was very dark and fetid; a few drops falling on the linen stained dark brown; only a few drops passed during the day (fourth day); suppressed , passed three tablespoonfuls of urine by means of catheter, of a lighter color than formerly (fifth day); procured a tablespoonful of urine by the use of the catheter, at 9 A.M.; passed a tablespoonful containing albumen, at 8 P.M. (sixth day); scanty discharges from the bladder of a yellow color, and very fetid; contained a large amount of albumen (seventh day); thought we detected casts of the uriniferous tubes in the ounce of albuminous urine obtained by means of the catheter (eighth day); albuminous, but of better color and larger quantity than at any time since the suppression commenced, containing mucus and albumen (ninth day); kidneys more active; urine more copious, but albuminous, fetid (tenth day); passed involuntarily for the first time in her sickness, more copious and containing blood and albumen (eleventh day), .

SEXUAL ORGANS

Male.
Numerous erections, even after coition, 109.
Strong dragging in the spermatic cord, so that the testicles seemed drawn up to the inguinal ring; this lasted for half an hour (after three-quarters of an hour), 124.
Female.
Abortion, period about two months, mass perfectly black, 149. [530.]
Abortion, 83.*
A six months' fœtus was born; the discharge of the placenta was immediately followed by profuse vomiting, violent jactitation, præcordial pain, pallor, coldness of the surface, the uterine contractions recurring at irregular intervals; this continued for half an hour, until unconsciousness and strabismus ushered in death, 151.
Death of the fœtus, 107.
Miscarriage, followed by tearing pain in the extremities, 141.
Miscarriage between the seventh and eighth months, 163.
Uterus and right ovary much congested and very sensitive to the touch ; sphincter vaginæ and vagina very much relaxed (eighth day), 155.*
On examination per vaginam found the os tinca open so as to admit the first phalanx of the index finger, very sensitive to the touch, hot, and engorged, with profuse flowing (first day), 155.
Os uteri wide open, thick, soft (before delivery), 98.
The uterus, that had previously been in a normal condition, descended so that it almost protruded from the labiæ, was hot and painful; the os was open as large as the middle finger; the patient complained of excessive desire to urinate, and of labor pains, only relieved by wet bandages or by pressure upon the abdomen; this lasted three days. She did not miscarry, though the os remained open during this period; afterwards the uterus gradually ascended, the pains diminished and after five or six days the os again contracted. The woman went on to the eighth month, when she miscarried, 169.
Retention of the placenta due to hour-glass contraction of the uterus and subsequent sterility, 107. [540.]
Uterine hæmorrhage, 149.
Hæmorrhage from the uterus, and apparent death of the new-born child, .

RESPIRATORY ORGANS

Voice.
The voice became weak, unintelligible, stammering, 64.*
The voice is weak and unintelligible, stammering, 61.
Cough and Expectoration. [560.]
Loose cough, with easy expectoration of much tenacious mucus, 109.
Blood was sometimes expectorated during violent efforts to breathe, 64.*
Respiration.
Respiration costal (first day), 155.
Respirations 15, 125a.
Respirations, 21 (before experiment); 20 (after one hour), 126.
Respirations, 19 (before experiment); 8, slow and small (after three hours), 94.
Respiration fell from 18 to 13, 106, 108.
Difficulty of breathing caused by contractions of the diaphragm, 145.
Respiration difficult, 64.*
Difficult respiration, as if a weight were lying on the chest, in consequence of which he was obliged to take deep and forced inspirations (after one hour), 126a.* [570.]
Laborious breathing, 115, 149.*
*Constant sighing (sixth day), 155.
The respirations decreased from 18 to 13 per minute, 108.
*Anxious respiration, 64.
Anxious difficult respiration, 42.*
*Anxious breath, sighing, and hiccough, 61.
Most violent asthma appeared after the suppression of the itch, and ceased on the reappearance of the eruption, 79.
Dyspnœa, 42, .*

CHEST

Oppression of the chest, 47, 50. [580.]
Sharp pressure in the sternum, 109.
Pressure in the chest, 132.
Pain in thorax, 99.
The whole upper portion of the left side of the chest, with the sternum, was painful, 110.
Suppression of milk; this effect has been noticed in six nursing women, 154.
The milk will not flow from the breast of a nursing woman, 42.

HEART AND PULSE

Heart.
Præcordial tenderness, but no fulness, 157.
The sounds over the præcordial region are perfectly normal, but convey an impression of slowness of time-taking action, 131.
Pressure in the præcordial region, 64.
Painful sensation in the præcordial region, 64. [590.]
Great præcordial anxiety, 100.
Præcordial anxiety, 153.
Disagreeable sensation in the præcordial region, 67.
Spasmodic throbbing of the heart, 64.
Violent palpitation, with contracted, frequently intermittent pulse, in an acute form of poisoning, 61.
Palpitation of the heart (after half an hour), 104.
Distressing palpitation, 110.
Her heart she described as having beat very rapidly for a long time, and her breathing as having been exceedingly laborious. After some hours the heart beat more quietly for a time, and then fell into inordinate activity as before; intermitting in this manner throughout the day, during the earlier part of which she lay perfectly motionless, but without pain, recovering gradually towards evening the suspended animal function, 45.
Pulse.
Rapid pulse, 127b, 128b.
Pulse rapid, small, hard, 149. [600.]
Pulse rather quick, but very small and feeble, 157.
Pulse very feverish, 48.
Rapid pulse, 153.
Accelerated pulse, followed by sleepiness, 148.
Pulse accelerated, 83.
Pulse quick, 151.
*Pulse small, very rapid, contracted, frequently intermittent, 64.
Pulse 112, 87.
Pulse 90 and small, 135.
It appeared to excite rather than diminish the pulse, in twenty-five or thirty minutes; in fifteen or twenty minutes, however, the pulse lost a few beats in a minute, but not to the same extent when given in larger doses, . [610.]

NECK AND BACK

Stiffness in the nape of the neck, 48.
The cervical muscles of the right side were stiff and painful on turning the head (second morning), 109.
Pain in the back and small of the back, with dragging and pressure in the lower abdomen, relieved by stooping (second day), 109. [650.]
Pain in the back (second and third days), 156a.*
Pain in the small of the back, 138.*
Violent pain in the small of the back (first day), 155.

EXTREMITIES

Most violent convulsive movements of the limbs occur several times a day; during the intervals the fingers are numb and often contracted, 70.*
The extremities were alternately violently flexed and extended, with an irresistible desire to stop the spasm by the force of the will, which he was imperfectly able to do, 64.
General convulsions of all the extensor muscles, and indeed a perfect access of puerperal convulsion under its peculiar form (soon after second dose), 117.
Sudden periodic contractions of the limbs , with tensive pain, 33.*
Convulsive movements of the limbs, 70.*
The limbs were very stiff, affected by the most violent spasms; yet there was an irresistible inclination to overcome the spasmodic contractions, so that as long as the spasm affected the extensor muscles there were constant attempts to flex the limbs, and when the flexor muscles were affected to extend them, 61.
Wonderful distortions, alternate flexions, and distensions of the limbs; even the fingers were violently bent backward, 64. [660.]
Contractions of the hands, feet, fingers, and toes, which the strongest man cannot prevent, 34.*
Various slow pandiculations and distortions of the hands and feet, especially in children, 42.
Spasmodic contortion of the extremities, 165.
Contraction of the flexor tendons, as though we would hop about, 165.
General trembling of the upper and lower extremities, especially on exertion, 140.
Trembling of the limbs, with bitter taste, 1.
The limbs trembled easily, 64.
Trembling of the limbs, 71, 142.*
Trembling of the limbs for several days, 72.
Indolence in the limbs, 3. [670.]
Distortion of the hands and feet, 77.
Arms and legs rigid, in a semiflexed and semipronated posture; pain on attempting to straighten the limbs, 138.
Paralysis of different limbs, .

SUPERIOR EXTREMITIES

Tonic spasms of the upper extremities, 86.
Shoulder.
Violent tearing pain in the right shoulder and upper arm, as if a string were tightly drawn around it, followed by painfulness of the muscles, for a long time, 109.
Pain in the left shoulder (sixth day), 155.
Very annoying pain in the left shoulder (fifth day), 155.
Arm.
Paralysis of the arm, 139.
Paralytic symptoms in the arms, with stiff and rigid flexion of the fingers, so that they could not be extended with the most acute pains, 100.
The arms fell asleep, 164.*
Wrist.
Soft, painful, watery swelling of the wrists, lasting several weeks, 42.
Hand.
The whole hand is drawn inward, so that the bones of the wrist are very prominent; the forearm is affected by spasms, and the hands are approximated to the chest; relief of the pain follows when one attempts to extend the flexed parts, 42. [750.]
Weakness of the hands; the patient could not hold anything securely, 140.
Contraction of the hands, 165.
The hands can with difficulty be carried to the mouth, the fingers are bent backward, and the eyes distorted, 61.
Crawling sensation in the hands and arms, 106.*
Fingers.
Gangrene, followed by spontaneous amputation of a finger, in one case, 145.
Fingers rigid, cold, shrivelled, painful to pressure, dry; hands covered with red erysipelatous spots, scales, and cracks, 111.
The fingers of both hands were flexed tightly into the hands, so that they could be opened with great difficulty; relief if the fingers were extended by another, but they immediately retracted again into the hand, 42.
Fingers so violently flexed that the strongest man could not extend them, 142.
The fingers were violently contracted, .

INFERIOR EXTREMITIES. [770.]

Two of the youngest were attacked with gangrene. One, a boy, ten years of age, after eating the bread during fifteen days, felt a severe pain from the left groin to the calf of the leg. The feet and legs became tumefied, covered with phlyctenæ, and the gangrene appearing at the inferior third of the legs, descended toward the feet and ascended to the upper part of the legs, where it became limited. The other, aged twenty-eight months, was attacked in the same way, but on one leg only, 133.
Convulsions of the lower extremities and most violent pains, 146.
The patients are able to walk only on the tips of the toes, on account of constant cramplike spasmodic contractions of the limbs, 61.
The lower limbs were flexed; she could not stand upright, and reeled as if intoxicated, yet was perfectly conscious, 42.
Occasionally slight convulsive twitches in the lower extremities were experienced by two of the individuals, 105.
Reeling gait, 145.
Gait difficult, tottering, 70.
Tottering gait, 86.
Inability to walk, 48.
Painful rigidity of the muscles, and an extreme lassitude in the lower extremities, causing considerable difficulty in walking (after second dose), 94. [780.]
Lower extremities paralyzed, 87.
Weakness of the lower extremities, so that the gait was unsteady and stumbling, 140.
Weakness and pains in lower extremities, 42.
Thigh.
Rigidity and soreness of the muscles, the muscles of the thighs and other parts of the lower extremities being more particularly affected, 95.
In the course of the day, a creeping sensation of insensibility upon the anterior part of the thigh and calf of the leg (second day), 124.
Leg.
Great weariness of the legs, followed by lasting pains, though worse at night, and would allow no sleep nor rest, 102.
Sense of weight and want of tone from the knees down, 131.
Painful sensation of weight in the calves and ankles (second day), 126a.
Occasional cramps in legs and feet, .*

GENERALITIES

Rapid emaciation, 35.
Child loses flesh, 116.
Hot gangrene, that eats the flesh from the bone, 23.
Cold gangrene and death attacked the nose, fingers, hands, arms, feet, tibiæ, and thighs, 3.
Dry cold gangrene, 34.
The gangrenous parts became black and separated from the body, 12.
Gangrene, 66.
Emphysematous swelling, 64.
Apoplexy, 63. [810.]
Extreme exhaustion, gangrene, or apoplexy, sometimes most violent epilepsy, followed by death, 64.
Hands, feet, ears, and nose became purple, and much of the surface assumed a mottled aspect (after twelve hours), 104.
General adynamic condition, under which the patients commonly succumbed about the tenth or twelfth day from the attack, 119.
Indications of a puerperal state (eighth day), 135.
Secretions diminished, 116.
Opisthotonos, 34, 162.
Emprosthotonos, opisthotonos, risus sardonicus, and raving, 47.
Emprosthotonos, 42.
Convulsive movements and twitching of the muscles and tendons of the limbs; twitchings of the muscles of the face (tenth day); twitching of the muscles (eleventh day), 135.
Violent paroxysms, consisting of contractions of the extremities, repeated at short intervals until the extremities became cold, stiff, and immovable, with violent pains in various muscles; in some cases the attacks became tetanic, with trismus and opisthotonos, or even epilepsy, followed by weakness of memory; the attacks frequently occurred suddenly in the night, 145. [820.]
Most frightful convulsions, followed by tetanus, 143.
Paroxysms usually better at night, so that the patient could at times sleep quietly, 100.
Convulsions, 66, 99, 141, 165.
Convulsions, etc., the convulsions sometimes carrying off the patient, .

SKIN

Objective.
Exhalations from the skin, of a vinous odor (fifth day), 155.
Exhalations from the skin fetid (second day), 135.
Desquamation of the whole body three times, in a girl, 47. [940.]
The epidermis begins to loosen from the affected parts, 64.
Skin soft, flabby, 70.
Skin dry, rough, 64.
Dry and withered appearance of skin, 116.
The skin, which in general was inclined to perspiration, was constantly quite dry, 124.
Dryness of the skin, with no trace of perspiration, 139.
Skin dry and cool, 135.*
The capillary action of the skin was remarkably slow, a portion of the skin deprived of its blood, by pressure with the finger, being a long time in recovering its color, 94.
Capillary action very slow, 95.
Capillaries of the skin appear to be empty (seventh day); more blood in the surface veins (ninth day), 155. [950.]
Skin hot, dry, and of a yellowish-brown color, resembling that of a mulatto (second and third days); hot, dry, but not as dark as if was the day before (fourth day); hot and dry, but of a better color, of a natural appearance on the feet and hands (sixth day); soft and more natural to the touch, but still very yellow (ninth day); yellow, soft, and moist (tenth day); most and yellow (eleventh day), 155.
Skin dry and of a muddy-yellow hue (second and third days), 156a.
Skin discolored, 142.
Skin had a yellowish tint, 157.
The child, when born, was in a state of perfect jaundice, and continued so until death, which took place on the second day, 117.
Skin everywhere deep red, 149.
Skin of a roseate hue, 90.
The whole skin assumes a leaden hue, shrinks and wrinkles, and becomes insensible, 64.
The skin of the affected parts becomes leaden-colored and wrinkled, the vessels disappear, the parts gradually become numb and lose all sensibility, so that she can be cut and pricked without pain, or without blood flowing from the wounds, .

SLEEP

Drowsiness and inclination to sopor (fourth day), 155.
Drowsiness (sixth, eighth, and ninth days), 155.
Strong desire to sleep (after one hour); the sleep the following night was disturbed by anxious dreams, 124.
Great sleepiness, 72, 84.
Sleepiness, 64.
Great inclination to sleep, 72.
Inclination to sopor (first day), 155. [1010.]
Stupefied slumber, for days, 47.
Deep and long-continued sleep, 72.
Almost complete sleep (in one hour), 167.
*Somnolency, 162.
Slept an hour and a half in the night, the first she had enjoyed during her illness (second night), 155.
Sleep restless, interrupted by anxious dreams, 64.
Passed a restless, feverish, and sleepless night, in a state of great nervous agitation, 156.
Sleep very restless, 12.
Sleep restless, with heavy dreams, 80.
Little sleep (first night), 126a. [1020.]
Sudden waking from sleep, with a wild staring look (tenth day), 155.
Sudden waking from sleep and looking wild, as if frightened, followed by palpitation of the heart (ninth day), 155.
Entire absence of sleep (second and third days), 156a.

FEVER

Chilliness.
Extremely violent chill, followed by burning heat, especially affecting internal parts, and associated with violent anxiety, so that many lose their reason, with violent, almost unquenchable thirst, 61.
Violent chill, followed by violent burning heat, with unquenchable thirst, 64.
A chill came on, followed immediately by nausea, sharp pain in the head, with dizziness and partial blindness, 156.
Rigors, with cutis anserina, 125.
Rigors, followed by heat and violent thirst (first day), 155.
Shaking chill, 48.
Creeping chill over the extremities (after one hour); chilliness over the whole body (after three hours), 126. [1030.]
General sensation of coldness in different parts of the body, as from cold water or from snow, 89.
Sensation of cold (after one hour), 126a.
Coldness of the surface of the body, and particularly the extremities, 157.*
Diminished temperature of the body, 147.*
*Cold skin, 122 ; (after three-quarters of an hour), 106.
Skin cold, particularly that of the face, 108.*
Temperature of skin low, with free perspiration (after two hours), 104.
Skin cool, 87.
Shivering, 122, 148.
Sudden shuddering, 48. [1040.]
Face cold and pale, 153.
Shivering in the limbs (after one hour), 123.
Temperature beneath tongue 98° Fahr., 131.
Sensation of great coldness over the back and abdomen, 64.
Heat.
Fever (first night and second day), 156.
Fever accompanies the pains in the stomach and abdomen, and pains in the limbs with internal heat, anxiety, and great thirst, .

CONDITIONS

Aggravation.
( Forenoon ), Spasms.
( Evening ), Pressure and dragging in hypogastrium.
( Night ), Spasms; pain in flesh.
( After eating bread ), Vertigo.
( Heat ), Pains.
( On appearance of menses ), The symptoms.
( During micturition ), Burning in urethra.
( On moving ), Dizziness of head; in bed, dizziness of vision.
( Moving head ), Black before eyes.
( When rising ), Dizziness of vision.
( Rising up in bed ), Black before eyes.
( On attempting to urinate ), Cutting and smarting in urethra.
( Warm air ), Prickling in stomach; pains.
( Warmth of bed ), Pains.
Amelioration.
( Open air ), Prickling in stomach.
( Extending flexed parts ), Pain in arm and hand.
( Stooping ), Pain in back.
( Sweat ), The symptoms.

SECALE CORNUTUM.