DIOSCOREA.

Dioscorea villosa, Linn.

Natural Order , Dioscoreaceæ.

Common name , Wild yam.

Preparation , Tincture of the root (or triturations of the resinoid, Dioscorëin).

Authorities.

1 , Dr. A.M. Cushing, Monograph on Dioscorea, provings with Dioscorea and "Dioscorëin," taken as follows; for first five days repeated doses of 1st dec. trit. of the resinoid, 5 to 20 grs. at a dose; sixth and seventh days, 2d trit.; eighth to eleventh day, 3d trit.; thirteenth and fourteenth days, 4th dec. in solution; fifteenth and sixteenth days, 5th dil.; seventeenth to nineteenth day, 6th dil. 50 to 100-drop doses; twentieth and twenty-first days, 6th dil.; thirty-first to thirty-fifth day, 8th dil., 500 to 3000-drop doses; forty-ninth to fifty-fifth day, tincture of Dioscorea , 5 to 20-drop doses; sixty-first to sixty-fourth day, 1st dec. dil., 25 to 50-drop doses; sixty-fifth to sixty-ninth day, 10th dec. dil. 25 to 100-drop doses; seventy-third to seventy-eighth day, 20th dil.; seventy-ninth to eighty-first day, 30th dec. dil.; 2 , Same, second proving (after six months); first day, 50 drops of 10th dil.; fifth day, same; sixth day, same; eighth day, 30th dil.; nineteenth day, 10th dil.; twentieth day, same; twenty-sixth day, 15th dil.; thirty-eighth day, same.; 3 , Dr. J. U. Woods, Hahnemannian Monthly, 4, 58, took 6th dil., one dose, 10 drops; 3 b , same, took 15th dil.; 3 c , same, took 6th dil.; 3 d , same, took 15th dil.; 4 , Dr. W. H. Burt took fluid extract, repeated doses of 30 to 200 drops, for three days, Hale's New Remedies, second edition, p. 307.; 5 , Dr. Thomas Nichol took 1st dec. dil. of Dioscorea first and second days; 1st dec. trit. of Dioscorëin sixth to eighth day, ibid.; 6 , Dr. Henry A. Summer took Dioscorein in doses of 1/2 to 2 grains, ibid.; 7 , Dr. J. C. Michener took Dioscorein in doses of 1/2 to 3 grains, ibid.

MIND

• Emotional.
• Desire to be alone; do not enjoy society; arm usually quite fond of the society of ladies, but they now seem repulsive, at 8 P.M. (twentieth day), 1.
• Great feeling of irritability (after eight hours), 3c.
• Intellectual.
• Feel dull; desire to be alone; conversation is troublesome, at 9 P.M. (twenty-seventh day), 1.
• Feel dull and stupid (after second dose, sixteenth day), 1.
• Feel dull and stupid in the afternoon, but feel well in the forenoon (twenty-first day), 1.
• Feel dull and cross at 8 P.M. (twentieth day), 1.
• Feel confused in the evening (after fourth dose, fourteenth day), 1.
• Call things by wrong names ; when I mean left leg or arm, I write it right arm or leg, and have to change it, in the evening (after fourth dose, fourteenth day), 1.*

HEAD

• Vertigo.
• Gradually vertigo and giddiness come on, which lasted for an hour, and was accompanied by rumbling of bowels (7 A.M.); sudden reappearance of the vertigo, with heat of the head; this continued with great violence for half an hour, and then subsided, but continued more or less all the evening (1.55 P.M.), (second day), 5b. [10.]
• Vertigo so violent that he was unable to walk, and reeled as if intoxicated, with aggravation of the frontal pains, at 5 P.M. (third day), 5b.
• Giddy, confused feeling of head (after three hours), (first day), 5b.
• Dizziness (seventy-seventh day), (part of S. 245), (eightieth day), 1.
• Head dizzy, and inclined to go to the right (seventy-fourth day), 1.
• Dizzy, inclined to go to the right when walking, in the morning (forty-seventh and fifty-seventh days), 1.
• Dizzy while eating (five hours after first dose, eleventh day), 1.
• Very dizzy, and dull pain in head, in the evening (ninety-fifth day), 1.
• General Head.
• Numb sensation of the head (twenty-ninth day); (part of S. 220), 1.
• Head feels dull and heavy; much inclined to remain quiet (after seven hours), 3.
• Dull uncomfortable feeling in the head as from cold (after one hour), 3c.
• Dull dizzy feeling of head (after fourth dose, third day), 11. [20.]
• Head dull and heavy, with an occasional quick pain through it at 4.20 P.M. (first day), 3b.
• Head dull (after seven hours and a quarter), 3c.
• Head dull and am dizzy; inclined to go to the right; in walking to a table went past it to the right, at 4 A.M. (forty-eighth day), 1.
• Head feels heavy; resting my head on my hand, it seems as if it would crush the head, it seems so heavy, at 9 P.M. (eighty-second day), 1.
• Head feels heavy, with pain between the eyes and both sides of the head near the top of the ears, at 8 P.M. (eighty-second day), 1.
• Pain in head (forty-first day), 2.
• Pain from nose and forehead to occiput at 9 P.M. (eighty-second day), 1.
• Pain in head in the morning (eighty-third day), .

EYE

• Eyes weak in the morning (forty-third day), 1. [140.]
• Both eyes weak and sore, and smart badly at 9 P.M. (twenty-third day), 1.
• Eyes weak at 10.30 P.M. (twenty-seventh day); morning (forty-third day), 1.
• Eyes very weak; blur before them (forty-eighth day), 1.
• Eyes feel tired at 4.20 P.M. (first day), 3b.
• Both eyes feel as if some foreign substance was in them, worse at times, right one worse in the forenoon (sixty-fifth day), 1.
• Eyes feel as if some large, smooth substance was in them at 8 P.M. (twentieth day), 1 ; (twenty-fifth day), 2.
• Left eye aches in the evening (ninetieth day), 1.
• Sharp pain in right eye at 8.30 A.M. (ninety-ninth day), 1.
• Sharp pain in left eye, am obliged to close it; relieved by pressure at 2 P.M. (seventy-eighth day), 1.
• Eyes sore at 10.30 P.M. (twentieth day), 2 ; (forty-second day), etc., 1. [150.]
• Eyes sore, left one worse, at 8.30 A.M. (seventeenth day), 1.
• Eyes sore in the afternoon (after first dose, eighteenth day), 1.
• Eyes sore in the night (twenty-third night), 1.
• Eyes sore, lids stuck together in the morning (sixty-second day), 1.
• Eyes sore and gummed up in the morning (sixty-third day), 1.
• Eyes sore and lashes stuck together in the morning (eighteenth day), 1.
• Eyes sore, right one stuck together for the first time in my life or remembrance, in the morning (twenty-fifth day), 1.
• Eyes sore; water runs from right one, and is troublesome at 1 P.M. (sixty-third day), 1.
• Both eyes sore; feel as if there were sticks in them (fourteen hours after first dose, eighteenth day), 1.
• Eyes sore and smart; water runs from right eye and smarts so bad I have to keep it closed most of the time in the evening (after first dose, sixty-second day), 1. [160.]
• Eyes are sore smart, and are gummed up in the morning (fifty-seventh day), 1.
• Eyes sore and smart badly; eyelids feel stiff; eyes do not look sore in the morning (seventeenth day), .

EAR

• Objective.
• Balls of wax fall out of the right ear (twenty-ninth, thirty-sixth, and seventy-fourth days), 1.
• External.
• Sensation in front of both ears, as if I would vomit (seventy-fourth day), 1.
• Hard pain in front of right, then in both ears, as if the head would burst (eighty-second day), (part of S. 860), 1.
• Dull pain in front of right ear and sharp pain over left eye at the same time (half an hour after third dose, sixteenth day), 1.
• Dull, squeezing pain in front of both ears, extending to the angle of the jaws (after 3000 drops, thirty-fifth day), 1.
• After going to bed, severe aching pain in front of right ear, lasting some time (twenty-ninth night), 1.
• Dull, pressing pain in front of both ears (after first dose, fourteenth day), 1.
• Pulling pain in front of both ears, as precedes vomiting (seven hours after first dose, fourth day), 1. [220.]
• Twisting pain in front of left ear, causing a numb sensation of the head at 11 P.M. (twenty-ninth day), 1.
• Sharp pain in front and behind both ears in the morning (sixteenth day), 1.
• Sharp pain over right ear at 9 P.M. (eighty-second day), 1.
• Sharp pain behind right ear in the morning (fifteenth day), 1.
• Sharp, deepseated pain behind right ear (five hours after first dose, thirteenth day), 1.
• Hard, sharp pain behind the left ear at 7 P.M. (seventeenth day), 1.
• Fine, sharp pains were felt behind left ear several times (third day), 3c.
• Darting pain behind left ear in the evening (after first dose, eighteenth day), 1.
• Sharp, darting pain behind left ear, extending in front of ear and to angle of jaw, in the morning (twenty-third day), 2.
• Right ear quite painful at 11 A.M. (sixtieth day), (part of S. 396), 1.
• Internal. [230.]
• Ears feel stopped up (after second dose, fourth day), 1.
• Both ears suddenly stopped at 8 P.M. (forty-fourth day), 1.

NOSE

• Objective.
• Much sneezing every day (sixty-third day), 1.
• Violent sneezing, with dizziness, soon after taking the medicine (seventy-seventh day), 1.
• Constant watery discharge from left nostril at 9 P.M. (eighty-second day), 1.
• Discharge of water from left nostril and smarting of fauces (after second dose, fourth day), 1.
• Discharge of bright blood from left nostril at 11 A.M. (fifty-ninth day), 1.
• Discharge of bright blood from left nostril, with spitting of blood for a half hour, in the morning (fortieth day), 1. [250.]
• Discharge of bright-red blood from left nostril, followed by one dark clot and spitting of blood (one hour after first dose, thirteenth day), 1.
• Fluent coryza for two days (part of S. 60), 3b.
• Subjective.
• The inside of both nostrils dry and sore at 7 P.M. (seventeenth day), 1.
• Nose dry and bad smell in it at 11 P.M. (thirty-fourth day), 1.
• Nose inclined to be stopped up at 7 A.M. (thirty-ninth day), 1.
• Nose stopped up (seventy-first day), 1.
• Heat in left nostril (eighteenth day), (part of S. 76), 1.
• The soreness of the nose is all on the right side, with a small swelling, at 7 P.M. (seventeenth day), 1.
• Soreness on left side of nose better, but sore on top and right side (six hours after first dose, thirteenth day), 1.
• Sore place on left side of nose quite painful, but no redness nor swelling (five hours after first dose, eleventh day), 1. [260.]
• Inside of nostrils sore at 9 P.M. (twenty-third day), 1.
• Inside of nostrils smart (thirty-third day), (part of S. 170), 1.
• Irritation of the nasal passages and sneezing (while making first trituration), (first day), 1.
• Itching of right nostril at 3 P.M. (seventy-third day), 1.
• Smell.
• Bad smell in nose (thirty-first day); morning (thirty-third day), etc., .

FACE

• Cheeks.
• Sharp, severe pain in left cheek or lower portion of temporal region, followed by dry cough (six hours and three-quarters after second dose, tenth day), 1.
• Lips.
• Lips burn at 9 P.M. (thirtieth day), 1.
• Lips sore at 9 P.M. (twenty-third day), 1.
• Chin.
• Spasmodic action of lower jaw during the evening (after third dose, fifteenth day), 1.
• Spasmodic closing of the jaws and biting the tongue (after 1000 drops eighth dilution, thirty-third day), 1.
• Pain in the jaw near the teeth in the afternoon (seventeenth day), 1.
• Hard pain at angle of lower jaw, right side (sixty-third day), 1. [280.]
• Digging pain at the angle of left jaw, at 5 P.M. (thirty-sixth day), 1.
• Drawing pain at angle of jaw (half an hour after third dose, sixteenth day), 1.
• Grinding pain at angle of lower jaw, left side, at 6.30 A.M. (seventh day), 2.
• Dull, grinding pain in left lower jaw, between teeth and angle of jaw, at 7 P.M. (twenty-fifth day), 1.
• Sharp pain in angle of lower jaw, left side, at 10 A.M. (second day), 2.
• Sore pain at angle of jaw, left side, in the morning (twenty-second day), 1.
• Jumping, darting pain at angle of jaw, right side at 7 P.M. (twenty-fifth day), 1.

MOUTH

• Teeth.
• Pain in front teeth (after first dose, sixth day), 1.
• Pain in upper front teeth, at 6 P.M. (twenty-sixth day), 1.
• Pain in front lower teeth, at 3 P.M. (twenty-sixth day), 1. [290.]
• Sharp pain in the upper front teeth, in the morning (sixty-sixth day), 1.
• Front under teeth sore and painful (seventy-fifth day), 1.
• Pain in lower back teeth left side, extending to angle of jaw and parotid gland, at 6 P.M. (twenty-sixth day), 1.
• Very sharp pain in right upper molar tooth, in the afternoon (seventeenth day), 1.
• A sharp darting pain in a right upper molar tooth (which had been filled several years), as if I had touched a bare nerve, in the afternoon (seventeenth day), 1.
• Left side teeth feel sore (half an hour after third dose, sixteenth day), 1.
• Jumping pain in left upper teeth, in the morning (twenty-third day), 2.
• Gums.
• Gums on inside of front upper teeth swollen (five hours and a half after first dose, sixteenth day), 1.
• Soreness of the gum, extending of the mouth, in the afternoon (seventeenth day), 17.
• Gums and roof of month sore, at 9 P.M. (eighty-fourth day), 1.
• Tongue. [300.]
• Tongue coated, in the morning (fifty-seventh day), 1.
• Tongue slightly coated, in the morning (twenty-first day), 1.
• Tongue coated white (third day), 4.
• Tongue coated yellowish-white (second and fourth days), 4.
• Tongue coated yellow (second day), 5.
• Tongue coated brown, and is sore at the tip, in morning (twenty-eighth day), 1.
• Tongue coated slightly brown (in the morning), (twenty-ninth day); (7 A.M.), (thirty-ninth day), 1.
• Tongue coated heavily brown, in the morning (fifty-seventh day), 1.
• Heavy brown coating on tongue, in the morning (fifty-sixth day), 1.
• Tongue sticks to the roof of my mouth, in the morning (seventy-fourth day), . [310.]

THROAT

• Throat dry (six hours and a quarter after first dose, sixty-sixth day), 1.
• Belching of wind, but the throat is so dry that it stops the wind (thirteen hours and a quarter after first dose, sixty-sixth day), 1.
• Pain in back and right side of throat, causing a choking sensation (six hours after first dose, thirteenth day), 1.
• Throat and right ear quite painful, at 11 A.M. (sixtieth day), 1.
• Throat seems sore, but is not, in the morning (twenty-second day), 1.
• Throat feels sore, but is not, on swallowing (fifty-fifth day), (part of S. 1453), 1.
• Throat sore and am hoarse, in the morning (eleventh day), 1. [400.]
• Throat slightly sore, in the morning (fifty-sixth day), 1.
• Throat quite sore, during afternoon and evening (fifty-ninth day), 1.
• Smarting at throat (thirty-second day), (part of S. 514), 1.
• Irritation of throat, with inclination to cough, at 10 P.M. (thirtieth day), 1.
• Irritation of throat left side, extending to the ear and down the pharynx, causing cough, in the morning (twenty-seventh day), 1.
• Occasional irritation of throat during the day, much worse in the evening (forty-fifth day), 1.
• Throat irritated, in the morning (fifty-ninth day), 1.
• Tickling low down in the throat, causing a deep cough, at 6.30 A.M. (seventh day), 2.
• Tonsils.
• Tonsils slightly congested (third day), 4.
• Pain below the right tonsil, extending to the right ear, quite severe, at 11 A.M. (fifty-ninth day), 1. [410.]
• Burning of left tonsil and left side of throat (after first dose, third day), 1.
• Burning, then itching, of left tonsil (three hours and a half after first dose, third day), 1.
• Pulling pain in left tonsil, in the evening (twenty-sixth day), 1.
• Sudden stinging pain in right tonsil, at 2.30 P.M. (eighty-second day), 1.
• Fauces.
• Dryness of fauces (second day), 4.

STOMACH

• Appetite.
• Appetite very much increased, 6.
• Great desire for food, at 7 A.M. (thirty-second day), 1.
• Eructation and Hiccough.
• Eructations of wind, at 7 P.M. (thirty-seventh day), 1.
• Eructations tasting of rotten eggs (second day), 5. [440.]
• Raising of bitter wind (fourteenth day), (part of S. 495), 1.
• Raising sour bitter wind (fourteenth day), (part of S. 511), 1.
• Raising sour, bitter wind, with shuddering (one hour after fourth dose, fourteenth day), 1.
• Raising, belching, and gulping enormous quantities of tasteless wind (sixty-first day), (part of S. 537), 1.
• Belching of wind (first and twenty-fifth days), 1 ; (after one hour and a half first day), 5.
• Belching of wind, with shuddering and bitter taste in mouth immediately (thirty-fourth day), 1.
• Belching of wind, and bitter mouth, the bitter seems to be worse on the sides of the tongue, and back part of it during evening (twenty-first day), 1.
• Belching of large quantities of wind (thirty-second day), (part of S. 494), 1.
• Belching of large quantities of wind, with a feeling as if both temples were in a vice (six hours after third dose, fifteenth day), 1.
• *Belching of large quantities of tasteless wind, relieving the distress at the stomach for a minute (six hours and three-quarters after second dose, tenth day), 1. [450.]
• Belching of bitter-tasting wind (twelve hours after first dose, eleventh day), 1.
• Belching of wind, slightly bitter, causing or accompanied by shuddering (six hours and a half after first dose, thirteenth day), 1.
• *Belching of sour wind (one hour and a half after second dose, fifteenth day), 1.
• Belching of bitter sour wind, during the evening (after dose, twelfth day), 1.
• Continued belching of wind, tasting bitter and sour, with pain in epigastrium and left hypochondrium, in the evening (after fourth dose, fourteenth day), 1.
• Belching of sour water (fifteen minutes after first dose, fifteenth day), .

ABDOMEN

• Hypochondria.
• Pain in both hypochondria (8 P.M.), (twenty-first day), 2.
• Frequent cramping pains in both hypochondriac regions, during day (twentieth day), 2.
• Dull pain in both hypochondria, in the night (twenty-third night), 1. [580.]
• Sharp pain in hypochondrium, with urgent desire for stool, driving me out of bed, in the morning (seventieth day), 1.
• Cutting pain in hypochondrium, at 8 A.M. (seventy-first day), 1.
• Pain below right hypochondrium and at the left of umbilicus, in the morning (eleventh day), 1.
• Dull pain in right hypochondrium (twenty-third day), 1.
• Distress at left hypochondrium, at 6 A.M. (seventh day), 2.
• Pain in left hypochondrium (in the evening), (fourteenth day), (6 A.M.), (seventh day), 2 , etc., 1.
• Immediately after lying down in bed, a hard but not very sharp pain inleft hypochondrium, aggravated by lying on right side, but not changed by turning to left (twenty-second day), 1.
• A lame pain in left hypochondrium for half an hour, aggravated by motion, in the morning (ninety-eighth day), 1.
• Cramping pain in left hypochondrium, in the evening (fiftieth and ninetieth days), 1.
• Cramping distressed pain in left hypochondrium, at 3 P.M. (sixth day), 2. [590.]
• For one week had a sharp cramping pain very often in left portion of left hypochondriac region and right side of right hypochondriac region (twelfth day), 2.
• Aching pain in left hypochondrium, and faint feeling at stomach, with chills in back, pain in right temple, sharp pain in middle of left tibia, belching of acrid wind, with shuddering (one hour and a half after third dose, fourteenth day), 1.
• Hard aching pain in left hypochondrium, relieved by motion, at 10.30 P.M. (twenty-seventh day), 1.
• Digging pain in left hypochondrium (after 5 P.M., twelfth day), 1.
• Dull pain in left hypochondrium (in the morning), (twenty-eighth and twenty-ninth days); (1 P.M.), (fifty-eighth day), 1.
• Dull pain in left hypochondrium, when lying upon the left side, at 9 P.M. (twenty-third day), .

RECTUM AND ANUS

• Pain in rectum (twenty-first day); (part of S. 685), 1. [760.]
• Hard pain in rectum in the morning (seventy-eighth day), 1.
• Hard, aching pain in rectum in the evening (after third dose, fifteenth day), 1.
• Dull pain in the rectum in the morning (fortieth day); (part of S. 794), 1.
• Occasional pulling, twisting pain in rectum (six hours after third dose, fifteenth day), 1.
• Darting pain in the rectum in the evening (forty-first day), 1.
• Sharp, darting pain in rectum (six hours and a half after first dose, thirteenth day), 1.
• Irritation of rectum during the evening (forty-fourth day), 1.
• Sudden pricking pain in rectum at 5 P.M. (thirty-second day), 1.
• Itching of rectum (at 12 M.), (seventh day), 2 ; (7 P.M.), (seventeenth day), 1.
• Itching of left side of rectum; the tumor is on the right, in the evening (thirty-ninth day), 1. [770.]
• Violent itching of the rectum, cannot sit nor stand still, at 1 P.M. (thirty-sixth day), 1.
• Moisture around the anus (forty-sixth day), 1.
• Involuntary discharge of mucus from the anus (eighty-seventh day), 1.
• Oozing of mucus from the anus, quite troublesome, in the evening (forty-third day), 1.
• The old hæmorrhoidal tumor had nearly all disappeared, but to-day it returned, and is quite sore (thirty-first day), 1.
• Hæmorrhoidal tumor sore at 8.30 A.M. (thirty-ninth day), 1.
• Hæmorrhoidal tumor quite sore all day (thirty-fourth day), 1.
• Hæmorrhoidal tumor quite sore in the morning; very sore at 12 M.; have to move with care (thirty-second day), 1.
• Three hæmorrhoidal tumors have made their appearance, and one partially prolapsed (second day), 4.
• Stool, in the morning, followed by protrusion of four hæmorrhoidal tumors, the size of large red cherries, with great pain and distress in anus. The hæmorrhoidal tumors are constantly prolapsed, which is very distressing and painful (10 A.M.). Three of the hæmorrhoidal tumors are of the color of the mucous membrane of the anus, and are the size of very large red cherries; the other one is not so large, and is of a very dark, livid, blue color (12 M), (third day), .* [780.]

STOOL

• Diarrhœa.
• Diarrhœa (seventh day), 2.
• Diarrhœa in afternoon, each stool smaller than the preceding one; stools loose, slimy, with straining and pain in rectum (seventy-sixth day), 1.
• Slight diarrhœa (soon), 6.
• Frequent stools; some diarrhœa (eighty-eighth day), 1.
• During the morning four offensive stools, each one more slimy than the preceding one and more straining perhaps aggravated by drinking part of a glass of (slightly fermented), new cider the previous evening, though I am confident that the cider alone could not have caused it (twentieth day), 1.
• Have had four stools at 9 A.M., each one smaller than the preceding one, but more slimy and more straining, with less pain before stool, but more pain after stool; white, slimy stool, like the white of an egg, but lumpy, with great unavoidable straining and burning in rectum, with a sensation as if the fæces were hot, at 12 M. (thirty-ninth day), 1. [810.]
• Three loose stools (seventy-third day), 1.
• Three light-colored, loose, slimy stools; continued desire for stool (twenty-ninth day), 1.
• Three very offensive, bilious stools in the afternoon (seventy-fourth day), 1.
• Stool more natural at 7 A.M., followed in a half hour by desire for stool; another stool at 8 A.M. (thirty-seventh day), 1.
• Defecation, uncommon at that period (noon), (third day), 7.
• Stool driving me out of bed in a hurry at 2 A.M. (fifty-fifth night), 1.
• Very profuse, thin, yellow stool, in morning, that did not relieve the pain in bowels . Another very thin, deep-yellow stool, which relieved the pain a good deal, followed by great faintness at stomach; eating would not relieve it (7 A.M.), (fifth day), 4.*
• Loose stool, with straining and slight protrusion of the old hæmorrhoidal tumor, followed by pain in both knees; worse on going upstairs; the right one worse (six hours after first dose, fiftieth day), 1.
• Loose, watery stool, with shuddering, but no pain, in the morning (fifty-second day), 1.
• Loose, offensive stool in the morning (sixty-sixth day), 1. [820.]
• Quite loose stool in the morning; one and one-half hour later, another small, light-colored stool, with much straining (twenty-first day), .

SEXUAL ORGANS

• Constant excitement of genital organs, with frequent erections night and day (fifty-second day), 1.*
• Genitals relaxed and cold in the evening (after first dose, sixty-second day), 1.* [850.]
• Genitals cold in the evening (sixty-first day), 1.
• Genitals cold and almost insensible (forty-second day), 2.
• Continued inaction of the genital organs at 10.15 P.M. (eightieth day), 1.
• No erections for many days (forty-second day), 1.
• Pain in penis and left testicle during afternoon (twelfth day), 1.
• Scrotum cold and moist; penis cold, and no erections for many days (twenty-seventh day), 2.
• Strong-smelling perspiration on scrotum and pubes , quite uncommon (six hours and a half after first dose, thirteenth day), 1.*
• Very sudden pain in both spermatic cords, extending to the testicles, in the morning (thirty-fifth day), 1.
• Cramping, aching pain in left spermatic cord, extending to the testicles, at 6.30 A.M. (seventh day), 2.
• Diminished sexual desire in the evening (sixty-first day), 1.* [860.]
• Sexual desire greatly diminished (fifty-seventh day), 1.*
• Sexual desire sadly diminished (twentieth day), 1.*
• Sexual desire all gone; genitals cold and relaxed; no erections for many days (seventy-fourth day), 1.
• *Emission of semen during sleep (fiftieth night), 1.

RESPIRATORY ORGANS

• Larynx, Trachea, and Bronchi.
• Inclination to cough (twentieth day); (part of S. 884), 1.
• Inclination to cough, from irritation deep in the throat, at 2 P.M. (eightieth day), 1.
• Inclination to cough in the morning; violent attack of coughing from tickling low down in the throat; can but just get my breath; cannot walk; frothy expectoration, it seems to come from the head; when coughing, the cough gives such a pain at lower end of sternum that I can hardly move, followed by a hard pain in front of right, then in both ears, as if the head would burst, at 8 A.M. (eighty-second day), 1.
• Feel inclined to cough, from tickling in throat, at 9 P.M. (eighty-second day), 1.
• Irritation of larynx and inclination to cough (five hours after second dose, tenth day), 1.
• Constriction of glottis, as if I was choking, or something swollen or tied around my throat (two hours and a quarter after first dose, sixty-sixth day), 1.
• Cough and Expectoration. [870.]
• Cough (twenty-seventh day); (part of S. 404), 1.
• Cough caused by irritation of right side of throat (after thirteen hours and a quarter, seventy-seventh day), 1.
• Deep cough (five hours after second dose, tenth day), 1 ; (seventh day), (par of S. 407), 2.
• Deep and dry cough in the morning (twelfth day), 1.
• *Hacking cough from tickling low down in throat (thirteen hours and a quarter after first dose, sixty-sixth day), 1.
• Dry cough (tenth day); (part of S. 273), 1.
• Profuse, frothy expectoration that seems to come from the head (eighty-second day); (part of S. 860), 1.
• Spitting blood for a half hour (fortieth day); (part of S. 249), 1.

CHEST

• Distress across and in upper portion of chest, producing difficult breathing, relieved by a deep inspiration (after twenty minutes eighth day), 2.
• Flying pains all through chest and back (cervical portion), (second day), 4. [880.]
• Distress in left lung, near the heart, at 12 M. (twenty-ninth day), 1.
• Pain in both lungs (after third dose, fiftieth day), 1.
• Pain in centre of right lung, in the evening (fifty-fourth day), 1.
• Pain in right lung, just above the nipple, at 8 P.M. (twentieth day), 1.
• Pain in right lung, one inch below the nipple; it feels as though it would arrest breathing, but is not aggravated by deep inspiration, but gives an inclination to cough, at 8 P.M. (twentieth day), 1.
• Pain in centre of right lung, in the morning (thirty-fourth day), 1.
• Pain in right lung then the left, in the morning (twenty-second day), 1.
• Pain in left lung, in the morning (eighty-fourth day), 1.
• Pain in upper portion of left lung, at 2 P.M.; of right lung, at 4 P.M. (thirty-first day), 1.
• Pain in left lung, above the nipple, in the morning (fifty-third day), 1. [890.]
• Pain in left lung, parallel with and at the side of the nipple (five hours and a half after first dose, sixteenth day), 1.
• Frequent pains through left lung, at 9 P.M. (twenty-seventh day), 1.
• Hard pain through the right lung, just below the nipple, as if it would arrest breathing, but relieved by deep inspiration, at 9 P.M. (eighty-second day), 1.
• Hard pain in centre of left lung, back side, at 9.30 P.M. (eighty-first day), 1.
• Hard pain through top of left lung, at 4 P.M.; through top of right lung, at 9 P.M. (thirtieth day), 1.
• Hard pain in upper posterior part of left lung at 12 M. (thirty-third day), 1.
• Hard pain in back portion of leg lung, in the morning (seventy-fourth day), 1.
• Burning sensation in left lung, in region of nipple, at 2 P.M. (fifty-fourth day), 1.
• Tightness across the upper part of the chest, at 11 P.M. (after dose, fifty-first day), 1.
• Sudden sharp cramping pain in right lung, just below the nipple, arresting motion and breathing for a few seconds, at 6 P.M. (twenty-eighth day), . [900.]

HEART

• A faint distressing sensation as if it comes from the heart, for two or three days (ninety-fourth day), 1.
• Pain in region of heart, in the morning (sixty-fourth day); (twelve hours and a half after first dose, seventy-sixth day), 1.
• Pain in region of heart, with faint feeling, in the morning (sixty-third day), 1. [950.]
• Sharp pain in region of heart, in night (fifty-fifth day), (part of S. 1453); (seventy-fourth day), 1.
• Sharp pain in region of heart, arresting motion, early in the morning (ninety-eighth day), 1.
• Sharp pain in region of heart; had to stop when walking, in the forenoon (nineteenth day), 1.
• Sharp pain in region of heart, and to the left of it (one hour and a half after first dose, sixteenth day), 1.
• Sharp pain and faint feeling at region of heart, at 7 P.M. (thirty-seventh day), 1.
• Occasional sharp pain in region of heart (two hours and a quarter after first dose, sixty-sixth day), 1.
• Frequent sharp pains in region of heart, in the morning (thirty-eighth day), 1.
• Frequent sharp, pain in region of heart, for a few seconds at a time, in the morning (sixteenth day), 1.
• Catching pain in region of heart, in the evening (forty-first day), 1.
• Stitching pain in region of heart (after half an hour, first day), 5. [960.]
• Sharp darting pain in region of heart, arresting breathing, at 4 P.M. (twenty-ninth day), 1.
• Sharp, pricking pain in region of heart, in the evening (twenty-sixth day), 1.
• Heart's Action.
• Can hear heart beat after walking a little (second day), 4.
• Awoke suddenly from sleep with hard, but slow, beating of the heart, shaking the chest (thirty-seventh night), 1.
• Pulse.
• Pulse 80 (second day), 4.
• Pulse 62, while lying down (fourth day), 4.

NECK AND BACK

• Neck.
• Pain in back of neck, in the evening (after first dose, eighteenth day), 1.
• Dull pain in back of neck, in the morning (twentieth day); at 7 A.M. (twenty-fifth day), 1.
• Severe dull pain in the back of neck, extending to back of head and both shoulders, worse in left (eight hours after second dose, tenth day), 1.
• Hard, pulling pain in back of neck, worse on left side, in the morning (sixteenth day), 1. [970.]
• Drawing, pulling pain in cervical vertebræ, at 1 P.M. (twenty-seventh day), 1.
• Sharp, twisting pain in back of neck, left side, then right side, at 3.30 A.M. (forty-second day), 1.
• Back.
• Back lame , in the morning (thirty-third, sixty-eighth, seventy-fifth, and seventy-ninth days), etc., 1.
• Very lame back (fourth day), 4.
• Back very lame, in the morning (eighty-second day), 1.
• Back in region of liver, so lame that it is almost impossible to turn in bed; relieved by moving around the room, in the morning (sixty-second day), 1.
• Pain in back (two hours and a half after third dose, sixteenth day); (twenty-first day), 2.
• Pain across the back, in the region of the liver, in the morning (fifty-seventh and fifty-eighth days), 1.
• Back painful and lame (fortieth day), 2.
• Hard pain in back and central portion of right lung, at 12 M. (twenty-ninth day), 1. [980.]
• Hard pain through the back, central portion of right lung (twelve hours and a half after first dose, seventy-sixth day), 1.
• Very severe backache (third day), 4.
• Dull aching pains in back (second day), 4.
• Dull pain in back, in the morning (thirty-third day); (fifty-fifth day), (part of S. 1453), 1.
• Very sharp pain in left side of back, at tenth rib, very sudden; made me jump; in the afternoon (after first dose, eighteenth day), 1.
• Dorsal.
• Lameness of dorsal region, at 6 A.M. (seventh day), .

EXTREMITIES IN GENERAL

• Objective. [1040.]
• Nails on fingers and toes seem unusually brittle, at 3 P.M. (forty-second day), 1.
• Hands and feet feel quite stiff (sixth day), 4.
• Pain in left arm, left leg, and left foot, in the morning (twentieth day), 1.
• Pains in joints and bones (twenty-first night), (part of S. 1526), 1.
• Pain in elbows and knees, during the day (forty-eighth day), 1.
• Pain in right knee, right ankle, and right elbow, in the morning (seventeenth day), 1.
• Pain in left hand and right knee, at 1 P.M. (fifty-eighth day), 1.
• Occasional pains in bones, during forenoon (twenty-first day), 1.
• Occasional pain in joints, in the morning (ninety-fourth day), 1.
• Occasional pains in elbows and knees, in the evening (forty-seventh day), 1. [1050.]
• Frequent pains in joints (twenty-fourth day), 1.
• Cramping pain in the arms and legs (eightieth night), (part of S. 536), 1.
• Bones ache (fifty-fifth day), (part of S. 1453), 1.
• Hands and fingers ache, and are very stiff; closing the hands is very painful; ankles, feet, and toes are also very stiff, and ache constantly. After exercising two hours hands and feet felt quite free from pain (third day), 4.
• Frequent aching pains in knees and elbows, at 6 P.M. (twenty-eighth day), 1.
• Constant aching distress in hands and feet (third day), 4.
• Dull aching distress in wrists, hands, fingers, ankles, feet, and toes (third day), 4.
• Dull aching pains in wrists, hands and fingers, ankles, feet, and toes; they are feeling quite stiff (third day), 4.

SUPERIOR EXTREMITIES

• Shoulder.
• Left shoulder is lame and painful; it seems as if I cannot move it, but it is relieved by movement, at 7 P.M. (twenty-fifth day), 1.
• Pain in both shoulders left one worse, in the morning (twenty-second day), 1. [1060.]
• Pain in right shoulder (twenty-second day), 2.
• Pain in left shoulder (an hour and a half after first dose, sixteenth day); at 8.30 A.M. (seventeenth day), etc., 1.
• Pain and soreness in right axilla, extending down the arm, aggravated by walking (three hours after third dose, sixteenth day), 1.
• Pain in left axilla (thirty-fourth day), 1.
• Pain and soreness in left axilla, at 1 P.M. (thirteenth day); at 8 P.M. (twentieth day), etc., 1.
• Occasional pains in shoulder-joints, in the forenoon (thirty-ninth day), 1.
• Frequent pains in left shoulder, during forenoon (after first dose, fifteenth day), 1.
• Frequent pains on top of left shoulder (an hour and a half after second dose, fifteenth day), 1.
• Hard pain on top of left shoulder, in the afternoon (after first dose, eighteenth day), (after one hour and three-quarters,seventy-seventh day), 1.
• Pain in top of left shoulder, so severe that I cannot sit still; chloroform applied; gave relief, but it soon returned; the pain extends up into the neck, at 7 P.M. (twenty-fifth day), 1. [1070.]
• Burning on top of left shoulder, in the evening (forty-first day), 1.
• Aching pain at top of left shoulder, at 1 P.M. (twenty-fifth day), 1.
• Hard aching pain in left axilla (two hours and a half after second dose, fiftieth day), 1.
• Dull heavy pain in shoulders (fifty-sixth day), (part of S. 138), 1.
• Dull pain in left shoulder (half an hour after second dose, eighth day); at 11 P.M. (twenty-third day), 1.
• Dull pain in top of left shoulder (seventieth day), 1.
• Drawing pain through both shoulders, in the morning (twenty-third day), 1.
• Frequent drawing pain in the left shoulder and neck (two hours after second dose, first day), 4.
• Sharp drawing pain in right shoulder, extending to the back portion of the lung, at 7 A.M. (twenty-sixth day), .

INFERIOR EXTREMITIES

• Objective.
• Getting out of a chair or walking is difficult at 2 P.M. (fortieth day), 1. [1200.]
• Right leg lame whole length at 3 A.M. (seventy-ninth day), 1.
• Occasional cramping pains in back side of legs, worse above the knees, at 1 P.M. (fifty-eighth day), 1.
• Dull pain in right leg, whole length, on back side, worse at buttock and heel (six hours and three-quarters after second dose, tenth day), 1.
• Right hip lame, every day, as if the gluteus muscles were too short, aggravated by walking, relieved by rest, at 2 P.M. (seventy-eighth day), 1.
• Pain in right hip in the morning (twenty-second day); (nine hours and a half after first dose, sixty-seventh day), 1.
• Pain in right hip, extending down front side of leg, near to the knee; have to limp when walking, in the evening (after first dose, eighteenth day), 1.
• Dull pain in hip and legs (fifty-fifth day); (part of S. 453), 1.
• Dull pain in left hip in the evening (after first dose, eighteenth day), 1.
• Dull pain in left hip, also in heel and sole of foot, in the morning (twentieth day), 1.
• Dull, hard pain in right hip at 8.30 A.M. (seventeenth day), 1. [1210.]
• Dull, tearing pain in right hip, hindering walking (after sixteen hours and a half, sixty-fourth day), 1.
• Sharp pain in right hip-joint (five hours and a half after first dose, sixteenth day), 1.
• Thigh.
• Pain in right thigh (after first dose, fourteenth day), 1.
• Pain in left thigh in the morning (twenty-second day), 1.
• Pain extending up left leg, from the knee, at 9 A.M. (twenty-ninth day), 1.
• Pain in right leg, above the knee, in the evening (after first dose, eighteenth day), 1.
• Cramping pain all day in right thigh, back side; the muscles seem too short; it is painful when walking (eighty-sixth day), 1.
• Cramping pain in back side of left leg, midway from hip to knee; same kind of pain in same place, right leg, at 9 P.M. (sixty-ninth day), 1.
• Hard, aching pain in right leg, just above the popliteal space, at 4 P.M. (twenty-fifth day), .

GENERAL SYMPTOMS

• Objective.
• For two or three days past my nerves have been uncommonly steady (fifty-third day), 1. [1420.]
• Trembling, with faint feeling at stomach (six hours after first dose, thirteenth day), 1.
• Laid in bed till noon (fifty-sixth day), 1.
• Restless, cannot go to sleep (nineteenth night), 1.
• After retiring, restless and uneasy (twenty-third night), 1.
• Restless, relieved by walking at 4.20 P.M. (fifth day), 3b.
• Felt uneasy at 4 P.M. (first day), 3b.
• Great uneasiness (after eight hours), 3c.
• Subjective.
• Feel nervous, easily troubled (two hours and three-quarters after first dose, sixteenth day), 1.
• Feel languid in the evening (after first dose, eighteenth day), 1.
• Feel languid and bad (ninety-fifth day), 1. [1430.]
• Unusual languor on awaking, with disinclination for mental exertion (first day), 5b.
• Feel tired and languid, still keep moving around the room, restless (half an hour after third dose, sixteenth day), 1.
• Feel weak and a lack of ambition (after seven hours and a quarter), 3c.
• Feeling very weak, hands and legs tremble constantly (second day), 4.
• Disinclination to move by reason of weakness (after eight hours), 3c.
• Faint feeling, came near syncope at 3 A.M. (ninth day), 1.
• At stool, faint sensation, near syncope; feared I should faint, at 12 M. (thirty-ninth day), 1.
• Faint, chilly feeling at 7 A.M. (thirty-ninth day), (part of S. 655), 1.
• Sick, faint sensation (part of S. 794), 1.
• Bad, faint feeling after going to bed (seventy-ninth day), 1. [1440.]
• Awoke in the night with a faint, numb feeling; sitting up in bed increased the faint feeling; lying down increased the numb feeling lying upon the back and pulling the hair in front of both ears for some time relieved it (twenty-sixth night), 2.
• Feeling very faint and weak; have to lie down to keep from fainting; seems to all centre at the stomach. Fearing spasms, took three doses of camphor without relief. Then inhaled chloroform every few minutes for two hours. The chloroform gave great relief, but only for a short time, after which the great faintness would come on again; after three hours the faintness left (third day), .

SKIN

• Burning and itching over both scapulæ most of the evening (fifty-first day), 1.
• Burning and itching over left scapula at 9 P.M. (twenty-seventh day), 1.
• Sudden stinging in various parts of the body, like bee-stings, in the evening (forty-second day), 1.
• Sensation as of a bee-sting on outside of left ankle at 5 P.M. (eighty-second day), 1.
• Creeping, tingling sensation all through the thighs and legs, relieved by rubbing (after seven hours), 3.
• Itching of various parts of the body and limbs (six hours and a half after first dose, thirteenth day); at six P.M. (eightieth day), 1. [1460.]
• Itching over right shoulder (twenty-second day), 2.
• Itching between the shoulder-blades at 5 P.M. (thirty-second day), 1.
• Itching between and over both scapulæ in the evening (ninetieth day), 1.
• Itching over both scapulæ in the evening (after first dose, sixty-second day), (seventy-sixth day, twelve hours and a half after first dose), 1.
• Itching over both scapulæ, worse on right (twenty-third day); at 9 P.M. (sixty-ninth day), 1.
• Itching over both scapulæ and left side of chest in evening (forty-second day), 1.
• Itching over both scapulæ (six hours and a quarter after first dose); worse over right (twelve hours and a half after first dose); over right (eleven hours and a quarter after first dose, sixty-sixth day), 1.
• Itching over both scapulæ in the evening, worse on the right (eighty-fifth day), 1.
• Itching over right scapula at 10 P.M. (eleventh day), 2 ; at 8 P.M. (twentieth day), etc., 1.
• Itching over right scapula every evening (twenty-second day), 1. [1470.]
• Itching every evening over the lower portion of right scapula (eighteenth day), 1.
• Itching over left scapula at 3 P.M. (seventy-third day), 1.
• Itching over left scapula, then over right, at 11 A.M. (sixtieth day), 1.
• Itching over lower portion of left scapula (seventieth day), 1.
• Itching of wrists (ten hours and a half after first dose, eleventh day), 1.
• Itching every day on thighs and legs, worse on undressing or getting chilly (thirty-third day), .

SLEEP AND DREAMS

• Sleepiness.
• Unusually drowsy; feel asleep with a book in my hand at 5 P.M., 5b.
• All through the sleep there was a confused consciousness of the conversation going on around (first day), 5b.
• Went to sleep in my room, a very uncommon occurrence, in the afternoon (twenty-first day), 1.
• Sleeplessness.
• Impossible to sleep for some time after going to bed (eightieth night), 1.
• On going to bed, could not sleep as usual; had pains in joints and bones. At 1.30 A.M. was called up. On going to bed at 3 A.M., could not go to sleep; was quite restless (twenty-first night), 1.
• Restless, cannot sleep; multitude of dreams (twentieth night), 1.
• Restless all night (fifty-fifth day), (part of S. 1453), 1.
• Restless, cannot sleep (fifty-third night), 1. [1520.]
• Restless, dreamy night (twenty-second and twenty-fourth night), 1.
• Very restless night, and got up feeling languid and unrefreshed (first night), 5b.
• Slept well until midnight, after that was very restless until morning (third night), 4.
• Confused sleep, with anxious dreams (first day), 5.
• Dreams.
• Dreamy sleep (seventy-second night), 1.
• Sleep full of lascivious dreams (fiftieth and fifty-first nights), 1.

FEVER

• Chilliness.
• Chilly (during forenoon), (twelfth day), 2 ; (thirteenth day), (part of S. 611), etc., 1.
• Chilly in a warm room (six hours and a half after first dose, thirteenth day), 1.
• Chilly, as though I had taken cold, when sitting by a hot stove (six hours after first dose, sixty-first day), 1.
• Chilly, with very bitter mouth, at 1.30 A.M. (twenty-first night), 1. [1530.]
• Chilly, yet sweat easily (fifty-fifth day), (part of S. 1453), 1.
• Feel chilly and bad (after four hours and a quarter, seventy-seventh day), 1.
• Several times during the day, chilly, as if taken cold (after first dose, sixty-second day), 1.
• Very chilly after going to bed (twenty-second day), 2.
• Chills (part of S. 471); (thirty-ninth day), (part of S. 191), 1.
• Occasional chills (fifty-first day), (part of S. 741), 1.
• Several severe chills, during the evening; chilly, then perspire (fifty-fifth day), (part of S. 1453), 1.
• Shuddering (thirteenth day), (part of S. 451); (fourteenth day), (part of S. 442), etc., 1, 2.
• A cold sensation, extending from the end of the sternum to the navel, and about an inch in width, while around the navel there was an almost burning sensation (after thirty-three hours), 3c.
• Chills in back (fourteenth day), (part of S. 591), 1. [1540.]
• Chills on back, commencing over left scapula (one hour after first dose, fifth day), 1.
• Chills, beginning on back, worse over left scapula (eighth day), (part of S. 109), 1.
• Chilly over left scapula (after second dose, fourth day), 1.
• Sweat.
• Slept soundly, but perspired a good deal (second night), 4.
• Skin dry and hot (fourth day), 4.
• Warm sweat broke out on forehead, about 8 A.M. (second day), 5b.

CONDITIONS

• Aggravation.
• ( Morning ), Early, rheumatic symptoms; early, diarrhœa.
• ( Afternoon ), Dull, etc.
• ( Evening ), Smarting of eyes, on lying down, all symptoms.
• ( Night ), Rheumatic symptoms.
• ( After midnight ), Restlessness.
• ( Ascending stairs ), Pain in knees.
• ( Getting cool ), Itching over hips.
• ( Doubling up ), Pain about navel.
• ( While eating ), Dizzy.
• ( Inhalation ), Pain in region of liver.
• ( Lying down ), Colic; numb feeling; all symptoms.
• ( Lying on right side ), In bed, pain in left hypochondrium.
• ( Motion ), Fatigue; pain in left hypochondrium; during first hour, the pains.
• ( Pressure ), Pains along side of forehead.
• ( Sitting down ), After riding or walking, feeling in stomach; colic.
• ( Sitting still ), All pains.
• ( Sitting up in bed ), Faint feeling.
• ( During stool ), Feeling in head.
• ( Stooping ), Pains in temples; pains at epigastrium; lameness of lumbar, etc.; regions; pain in lumbar region ; pain in lumbo-sacral region.
• ( Walking ), Pain in temples; soreness of bowels; pain in bowels; lameness of hip; weakness of knee; pain at head of fibula; pains in umbilical region; pain in lumbar region.
• Amelioration.
• ( Open air ), Especially when moving, all symptoms.
• ( Contact ), Soreness, etc., of tibia.
• ( Eating ), Pain in epigastrium; weakness in small of back.

SUPPLEMENT: DIOSCOREA. Authority.

8 , Olin M. Drake, M.D., Pub. of Mass. Hom. Med. Soc., vol. iv, p. 575.

Had been subject to a dull, heavy pain at the inferior angle of the left scapula occasionally for the past twelve months, otherwise perfectly healthy.

October 29th, at 10 A.M., feeling perfectly well, took 1 grain of the first trit.; ten minutes after had considerable nausea, with rumbling in the cardiac portion of the stomach. 11 A.M., dull headache and nausea, both lasting till 3 P.M. At 3.30 had hard, lumpy stool. 10 P.M., all unpleasant effects had passed away; took 2 grains; fifteen minutes after sharp pain in left side, midway eighth rib, which hinders me in taking a deep inspiration, pain in right foot, base of second toe, passing off on motion, but immediately returning, lasting some six minutes; rumbling in the bowels; forty minutes after cutting pain in the right lobe of the liver, lasting some five minutes.

October 30th. Got up with bad-tasting mouth, tongue coated yellowish white; 10 A.M. took 1 grain; at once considerable nausea, but not so bad as yesterday; half an hour after the dull headache returned, through the temples mostly lasting till afternoon; 10 P.M. took 2 grains; twenty minutes after pain in umbilicus; in half an hour heaviness in head returns, an aching over right eye.

October 31st. Awoke, after sleeping well, with a horrid headache, so severe it made me reel; back feels weak and sore up and down the spine; whitish-coating on my tongue, with a sickening taste; 11 A.M., feeling well, took 1 grain, producing the usual feeling in my head, but no nausea; head felt bad until after dinner (2.30 P.M.); at 10.30 P.M., took 2 grains; unpleasant feelings through temples, no other effect.

November 1st. In morning, coated tongue; at 10 A.M., took two grains, producing no symptoms; 10 P.M., stool, first part lumpy, then diarrhœic; 10.30 P.M., took 3 grains, with no effect save heaviness in head.

November 2d. Slept well, tongue coated, taste not so bad in my mouth as yesterday morning; 11 A.M., took 3 grains; 10 P.M., soft stool, with considerable pain; 10.30 P.M., took 3 grains, followed by some rumbling in bowels.

November 3d. Slept well; felt sick at the stomach, and cared for no breakfast; at 9 A.M., diarrhœa stool, with considerable pain in the epigastrium, and cutting pain in rectum; 9.30 A.M., took 4 grains; rumbling in bowels.

November 4th. No symptoms since last dose; 9 A.M., took 6 grains; in fifteen minutes pain in region of gall-bladder; in twenty minutes heaviness of head returned; 10.45 A.M., head symptoms grow worse; great salivation, with a peculiar prickly feeling at the end of the tongue, as though it had been burned with hot drink; eructations from stomach, with a taste like bile.

November 5th. Had a restless night; woke up at 12 o'clock with a severe pain in right lobe of liver, also pain in left side (eighth rib), so severe could not sleep; spinal cord feels bruised all the way up and down; 3 P.M., have had pain off and on during the whole day in left side (eighth rib), in liver, and in left lumbar region; 3.30 P.M., took 14 grains; 10 P.M., severe headache since taking last dose; took 7 grains, producing pain in left side of head.

For a number of days after last dose, occasionally would feel the pains in the left side and in the liver, 8.