Alkaloid obtained from Coffea Arabica. Formula, C8H10N4O2.

Preparation , Triturations.

Authorities.

1 , Dr. C. G. Lehman, effects on students of doses of 2 to 10 grains, from Brill's monograph on C.; 2 , Dr. Frerichs took 25 grains, from the same; 3 , Dr. J. Lehman (see No. 12, under Coffea tosta), effects of 4 to 6-grain doses; 4 , Eustratiades, Thèse de Paris, 1870, conclusions from series of examinations of urine. (See also sphygmographic tracing, Plate II, Fig. 11 to 22, from 5 Marvaud, Aliments d'Épargne).

MIND

Emotional.
Great excitement, so that he was unable to fix the mind, 2.
Very excited fantasies, 3.
Peculiar intoxicated condition, 3.
Delirium, 1.
Visions, 3.
Intellectual.
Confusion of ideas, 3.
Obscuration of mind, 1.

HEAD

Slight vertigo, 2.
Pulsation of the arteries on the head and temples very marked, 2. [10.]
Head heavy and confused, 2.
Headache, 1.

EYE

Vision of sparks, 1.

EAR

Roaring in the ears, 1, 2.

STOMACH

Vomiting, with relief of all the symptoms (after one hour), 2.

URINARY ORGANS

Urethra.
Constant urging to urinate, but only very scanty discharge, 3.
Micturition.
Amount of urine increased 140 c.c.; urea diminished 2.9 grammes; phosphoric acid diminished 0.2 grammes; sodium chloride diminished 0.9 grammes, 3.
Amount of urine increased 4.84 c.c.; urea diminished 3.1 grammes; phosphoric acid diminished 0.37 grammes; sodium chloride increased 0.1 grammes, 3.
Urine.
Increase of urea during first twenty-four hours, 1.
First, Coffeine lessens the quantity of urea excreted, to a remarkable degree; diminution of 14.100 grammes the first week, from 15 centigrammes Coffeine; of 28.100 grammes, the second week, from 30 centigrammes. This diminution begins from the first day of taking Coffeine. On the subsequent days it is greater than at first, but is not afterwards increased (no cumulative action in the system, as in the case of Digitalin), 4.

SEXUAL ORGANS. [20.]

Erections, 1.

CHEST

Oppression of the chest, 1.

HEART AND PULSE

Palpitation, 1.
Pulse very rapid, 3.
Extremely frequent, irregular, and often intermitting pulse, 1.
Pulse full and hard, rising from 70 to 80, in fifteen minutes, 2.
On considering the changes in the pulse under the action of

Coffeine , they are seen to be very similar to those observed after drinking a decoction of raw coffee; only they are, as might be expected, more strongly marked, 5.

GENERAL SYMPTOMS

Great excitement of the nervous and vascular systems, 1.
Trembling, 3.
Great uneasiness, 2.

SLEEP. [30.]

At last very sound sleep, 3.
Loss of sleep, 1.

CONDITIONS

Amelioration.
( Vomiting ), All symptoms.

SUPPLEMENT: COFFEINUM. Authority.

5 , Dr. Kelp, Memorab., 22, 1877 (S. J., 176, 220), a woman took two powders of the citrate, each containing 0.24 gram.

She was seized with remarkable restlessness and dizziness, and could not keep erect. Violent præcordial anxiety, palpitation. Abdominal pulsation. Violent trembling of all the extremities. Grating of the teeth. Features expressive of the greatest anxiety. Feeling of constriction of the neck and throat, recurring periodically every fifteen minutes. Pulse very rapid. This condition lasted three hours, and gradually disappeared, 5.

Coffeinum