, C20H24N2

O,SH2O4 +4H2 O (Baup).

Preparation , Triturations.

Authorities.

1 , Rust, effects, Rust's Mag., 12, 3 (in Noack, Hygeia, 16, 148); 2 , Berandi, effect of 15 to 20 grains, Omad, Annali di Med., 1829 (ibid.); 3 , Barbier, effects of 4 to 8 grains of pure

Cinchoninum , Traité Elément de Mat. Méd., 1837 (ibid); 4 , Madam M., suffering lately from catarrhal cough (cured by the proving), and occasional leucorrhœa, took (first day) 1 grain, (second day) 2 grains (ibid.); 5 , Julian P., aged 25, complains of oppression of chest, want of breath, and weeping mood, took 1 grain (ibid.); 6 , Wilhelmina Deitz, a healthy girl of 19, took 2 grains, on the first and fourth and ninth days (ibid).; 7 , Wilhelmina Walter, girl of 17, never menstruated, but lately has had periodic menstrual colic, has just recovered, took 2 grains (ibid.); 8 , Fritz, aged 25, took (first day) 1 grain, (third day) 4 grains (seventh day) 6 grains (ibid.); 8 b , same prover took 12 grains at once (ibid.); 9 , Dr. Otto Piper took 8 grains (ibid.); 10 , Birkner, aged 23, took (first day) 4 grains, (sixth day) 8 grains (ibid.); 11 , Dr. Geyer took 2 grains (ibid.); 11 b , same one took 4 grains, second proving (ibid.); 12 , Dr. Noack took 4 grains (ibid.); 12 b , same prover took 10 grains (ibid.); 13 , Bouchardt and Delondre, Experiments, l'Art Med., 13, 3; 14 , Dr. Elson, experiments on the pulse, Am. J. M. S., N. S., 52.

MIND

Sort of transient intoxication, 13.
Complete disinclination for work (seventh day), 10.

HEAD

Confusion and Vertigo.
Confusion of the head (first day), 15.
Confusion of the head, becoming better towards noon (seventh day), 10.
Confusion of the head, with vertigo (tenth and eleventh days), 8.
Confusion of the head, with sensation as though the brain had increased in volume (sixth day), 10.
Confusion of the head, with pressive pain in it, and a kind of dizziness, at 9 P.M. (seventh day), 10.
Confusion of the head, with pressure in the eyes (third day), 7.
Vertigo, in the evening (third day), 7. [10.]
Dizziness (Berandi, from 20 grains), 13.
General Head.
Rush of blood to the head, with heat in it (second day), 4.
Heaviness of the head, and rush of blood to it, 2.
Head heavy, painful (0.70), 13.
Headache, 2.
Headache every morning, affecting the whole head, 6.
Headache, with vertigo and great thirst in the afternoon, on walking in the open air (fifth day), 7.
Headache, involving the whole head, worse on stepping, with sensation of dulness (seventh day), 6.
Headache, especially involving the left side, aggravated by stooping (seventh day), 8.
The headache returned every afternoon about 3 o'clock, became a general heaviness of the head, and towards evening a pressive pain, especially in the occiput and in the coronal suture, worse in the evening (sixth day), 10. [20.]
Severe headache (fourth day), 8b.
Specific headache, mostly in the anterior part, with a very remarkable sense of compression (0.70), 13.
Headache, as if the head would burst, especially worse in the occiput, on waking (sixth day), 8.
Pressive pain on the head, as from a heavy weight pressing the parietal bone against the brain (tenth day), 11b.
Forehead.
Pain in the anterior lobe of the cerebrum, as though a net were drawn through the whole substance of the brain (ninth day), .

EYE

Objective.
Sparkling eyes, which are heavy and difficult to open, 13.
Blue rings around the eyes (third day), 8b.
Accumulation of mucus in the eyes (second night), 11b.
Subjective.
Sensation as if the eyes were lying deep in the head (second day), 8b.
Pupil. [40.]
Pupil sometimes dilated, sometimes contracted, 13.
The pupil dilates only from poisonous doses; from less than a gramme it contracts, 13.
Vision.
Obscuration of vision, 2.
Attacks of darkness before the eyes (second day), 8b.
On exerting the eyes it becomes black before them, 6.

EAR

Humming in the ears (as from Sulph. Quinine, but a less constant effect), 13.
Ringing in the ears (sixth day), 8 ; (second day), 8b.
Frequent ringing in the ears, 6.
Roaring in the ears, 2 ; (fourth day), 7 ; (seventh day), 8.
Roaring in the ears, during the night (third day), 4.

NOSE. [50.]

Sudden nose-bleed, of thin bright red blood, while sitting (second day), 9.
Dryness of the nasal fossæ, followed by increased secretion, 13.

FACE

Animated countenance, 13.
Pale sickly color of the face (second day), 15.
Face pale and hollow-eyed, 6.
Face very much swollen about the eyes, which was perceptible on opening the lids (second day), 9.

MOUTH

Tongue.
Redness of tongue (Berandi, from 20 grains), 13.
Thick yellow coating at the root of the tongue, with clean moist edges (sixth day), 8.
Thin coating of mucus on the middle of the tongue (eighth day), 6.
Tongue covered with thin saliva-like coating (first day), 12b. [60.]
Dry tongue, with yellow coating, 1.
General Mouth.
Heat in the mouth, 6.
Sensation of heat, and as if burnt within the mouth and throat, 6.
Saliva.
Increased salivation, 2.
Accumulation of water in the mouth, especially in the forenoon (second day), 7.
Ptyalism (Berandi, from 20 grains), 13.
Dryness of the mouth and throat, 1.
At first the mouth is dry, followed by increased of saliva, but it remains gluey, frothy, 13.
Taste.
Taste pasty (first day), 12b.
Intolerably bitter taste, which goes off entirely on rinsing the mouth two or three times (immediately), 13.

THROAT. [70.]

Great dryness and roughness of the throat (fifth day), 7.
Burning in the throat, 1.
Sensation as if the throat were burnt with hot drink, and something were sticking in the pharynx, 6.
Sticking pains in the throat, as with fine needles, on swallowing (sixth day), 8.

STOMACH

Appetite.
Hunger, without appetite (sixth day), 8.
Great appetite (after seven days), 6.
Little appetite (second day), 7.
Very little appetite; became satiated and full from very little food (third day), 11b.
Loss of appetite (sixth day), 10, 11.
Thirst, 1 ; (seventh day), 8. [80.]
Thirst the whole day (third day), 12.
Thirst, in the afternoon (second day), 7.
Thirst and sweat, 8b.
Much thirst the whole day (second day), 8.
Very great thirst, especially on the sixth and seventh days, 6.
Eructations and Hiccough.
Eructations (after one hour), 4 ; (second day), 8b ; (sixth day), 10 ; (seventh day), 8.
Eructations of air, 5 ; (second day), 7 ; (fourth day), 4.
Eructations tasting of foul eggs, 11.
Frequent eructations, 6.
Sour eructations (fourth day), 7. [90.]
Hiccough, 1.
Heartburn.
Sudden heartburn (fourth day), 4.
Nausea and Vomiting.
Nausea, 2, 3.
Nausea (Berandi, from 20 grains), 13.
Nausea for several hours after dinner (first day), 12.
Nausea, continuing the whole day (second day), 7.
Nausea and eructations (soon after 4 grains), (third day), 8.
Transient nausea and inclination to vomit, before eating (fifth day), 7.
Slight inclination to vomit, 13.

ABDOMEN

Hypochondria.
Constant pain across the hypochondriac region, as from incarcerated flatus (sixth day), 11b.
Pressive pain in the region of the liver (fourth day), 7.
Umbilical.
Pain in the umbilical region, with passage of much offensive flatus (second day), 8.
General Abdomen.
Distended abdomen, many borborygmi, 6.
Abdomen distended; passage of much offensive flatus the whole day (first day), 12b.
Distension of the abdomen, after eating (sixth day), 8. [120.]
Distension of the intestinal region, 3.
Commotion in the abdomen, 5.
Slight motion of flatulence in the abdomen (first day), 12.
Rumbling in the abdomen (fourth day), 4 ; (sixth day), 8.
Rumbling in the abdomen, lasting twelve hours, 4.
Rumbling and gurgling in the abdomen (fifth day), 8b.
Flatulence, 1.
Very offensive flatus (fifth day), 8b.
Passage of flatus (third day), 10.
Passage of much flatus, 5. [130.]
Warmth in the abdomen, 1.
Sensation of heaviness in the abdomen, after eating, as if a stone were lying in it, lasting the whole afternoon, and only disappearing towards evening (first day), 12b.
A little pain, which extends all over the abdomen, 13.
Fulness of the abdomen (sixth day), 10.
Sensation of fulness in the abdomen (sixth day), 10.
Tension of the abdomen, 5.
Tension in the abdomen at night (third day), 12.
Abdomen tense, full, and heavy (first day), 12b.
Slight griping and commotion in the abdomen (first day), 12b.
Cutting in the abdomen; disappears after the evacuation of nineteen ounces of clear watery urine (third day), . [140.]

RECTUM AND ANUS

Frequent dragging and crawling in the anus, relieved by scratching (fourth day), 11b.
Dull cutting pain in the anus, extending thence to the navel, with fine stitches in the pit of the stomach (twelfth day), 11b.
Urging to stool at 10 P.M., with soft stool, very difficult to pass (third day), 12.

STOOL

Diarrhœa.
Diarrhœa, at times, 2.
Two diarrhœa-like stools (fifteenth day), 7. [150.]
Very pasty diarrhœa-like stool (third day), 10.
Two stools (first day), 6.
Two soft stools (first day), 5.
Copious stool, dark greenish-brown color, very large and thick, so that the anus pains after the passage (first day), 12b.
Stool copious, at first of the usual consistence, afterwards like diarrhœa (first day), 12.
Soft stool (second day), 8b.
Constipation.
Constipation, 1 ; (second and sixth day), 8.
Stool more sluggish than usual (second day), 10.
Hard scanty stool, towards evening (second day), 7.
Hard stools, with tenesmus, 3. [160.]
Stool thick, pasty, thin formed, and passed slowly and with much pressing; the sphincter is very much relaxed, as if paralyzed; the rectum on the contrary is more contracted than usual, which the prover recognizes not only from the thin-formed fæces, but also from a sensation difficult to describe, felt during the passage of the stool (fourth day), 11b.

URINARY ORGANS

Urethra.
Burning sensation in the urethra, after passage of urine (sixth day), 8.
Excessive urging to urinate, with pain in the sides of the abdomen towards the genitals, with frequent evacuation of large quantity of urine, which gradually relieved the pain (second day), 5.
Cinchonine produces opposite effects on the urine, according as it is given in larger or smaller doses. After 20, 30, and even 40 centigrammes, the prover had frequent urging to urinate; 70 centigrammes, on the contrary, caused a sort of retention, so that he had to make prolonged efforts to expel the contents of the bladder; the larger the dose, the less the urging, and the smaller the quantity passed, 13.
Micturition.
Increased secretion of urine (third day), 8b.
Frequent discharge of copious clear urine (second day), 7.
Evacuations of urine three times (first day); four times (second day); seven times (third day); three times (fourth day); three or four times (fifth day), etc., 6.
41 ounces of urine in four times (first day); 39 ounces in four times (second day); 74 1/2 in seven times (third day); 97 ounces in eight times (fourth day); 62 ounces in seven times (fifth day); 31 ounces in three times (sixth day), 12.
53 ounces of urine in five times; in the morning, very light-colored, in the afternoon less so; an acid reaction; nitrate of silver causes a profuse whitish-green sediment, "consisting of much free phosphates" (first day), 12b.
Retention of urine (Berandi, from 1 gramme), 13. [170.]
Urine first day 35 ounces, in four times, acid; second day, 43 ounces in four times; third day, 35 ounces in five times; fourth day, 56 ounces in five times; fifth day, 59 ounces in six times; sixth day (after 8 grains), 45 ounces in four times; seventh day, 30 ounces in four times (always with some sediment); eighth day, 56 ounces in five times; ninth day, 49 ounces in six times; tenth day, 56 ounces in four times; eleventh day, 45 ounces in four times, 10.
Urine.
Urine pale in the morning, depositing (after twenty-four hours) a slimy brownish-green sediment, of an offensive odor (urine passed on other days was high-colored, had a dark-red deposit; secretion of urine diminished; at most only three times a day), (second and third days), 9.
Urine acid, deposits soon a sediment, and is covered with an iridescent film (third day), .

SEXUAL ORGANS

Male.
Great sexual excitement and erections (eighth day), 11b.
Female.
Menstruation a week too soon, much worse than usual, 6.

RESPIRATORY ORGANS

Larynx and Bronchi.
Scraping in the larynx, lasting half an hour (soon), 9. [180.]
Much mucus, which collects in the bronchial tubes, must be hawked up with considerable exertion (first day), 12b.
Voice.
Hoarseness (sixth day), 6.
Hoarseness continues after sixth day of the first proving, 6.
Cough and Expectoration.
Cough loose, racking, shaking the head, with pressive pain in the stomach (fifth day), 6.
Loose cough, with slimy expectoration from deep in the chest, 6.
Respiration.
Whistling respiration (sixth day), 8.
Respiration slow and impeded, 13.
Loss of breath on walking rapidly, 6.

CHEST

The chest seems to be hollow and distended, so that breathing seems to be especially easy (first day), 12b.
Sensation as if the chest were quite hollow (sixth day), 8. [190.]
Painful tension across the chest (eighth day), 11b.
Constriction of the chest, as though the lips were pressed together in front (fourth day), 11b.
Oppression of the chest (sixth day), 8.
Oppression of the chest, with rapid respiration (sixth day), 10.
Stitches in the chest, mostly extending from the right side to the pit of the stomach, at the insertion of the diaphragm (second day), 8b.
Front.
Pressive pain beneath the sternum (tenth day), 11b.
Waking in the night with pains in the sternum; it seems as though the lower portion of the sternum were pressed inward (third day), 11.
Sides.
Sticking in the side, alternating in one and the other, especially aggravated by motion; these pains last during the second day, omit on the third and fourth days; reappear on the fifth; after the fifth day they extend more towards the back, affecting the whole length of the back, and especially seat themselves between the shoulder-blades, 6.
Stitches in the cartilages of the fourth and fifth ribs of the left side, in the morning (seventh day), 11b.

HEART AND PULSE

Præcordium.
Præcordial pain, which seems to compress the whole left side of the chest, 13. [200.]
The præcordial pains and slow respiration were constant symptoms, in a series of provings; and after 70 centigrammes the præcordial pain became so severe that the prover had to stop; it extended to the summit of the chest, 13.
Heart's Action.
Startings of the heart (0.70 grm.), 13.
Pulse.
Frequent pulse (Berandi, from 20 grains), 13.
Accelerated pulse, 2.
Heightened pulse (0.70 grm.), 13.
The Quinia, while it increased the volume of the pulse, did not appear to influence its rapidity, while the Cinchonia decidedly accelerated it, 14.

5 grains Cinchonia pr. 1/2 hr. till 11 doses,... Average, 76 10/11 10 grains Cinchonia pr. 1/2 hr. till 12 doses,... Average, 78 1/6 20 grains Cinchonia pr. 1/2 hr. till 11 doses,... Average, 94 8/10, 14.

Pulse before taking 56, after two hours 70, after six hours 84, and in the evening 45; second day, in the morning 54, at noon 82, in the evening 62; third day in the morning 56, in the afternoon 75, in the evening 64; fourth day in the morning 52, noon 78, in the afternoon 54; sixth day (after 8 grains) in the morning 55, after two hours 68, after dinner 88, in the evening 68; seventh day in the morning 56, noon 80, evening 72; eighth day in the morning 54, at noon 78, in the evening 58 (rather irregular); ninth day in the morning 54, noon 76, evening 54; tenth day, morning 53, noon 72, evening 54; eleventh day, morning 54, noon 76, evening 57, 10.
Pulse 65, small, weak, slow, regular, 6.
Pulse before taking, 85; 75 (after three-quarters of an hour); 65 in the evening (after eleven hours); 66 at 5 A.M. (second day); 70 at 10 A.M. (second day); 60 at 9 P.M. (second day), 12. [210.]
Pulse quiet, soft, regular (third day), 7.
Pulse generally weak and small (second day), 12.
Pulse small in the morning, weak and compressible; in the afternoon fuller and almost bounding; at 7 A.M., 66; at 10 A.M., 86; 3 P.M., 75; 9 P.M., 75, 12b.

NECK AND BACK

Neck.
Painful stiffness of the neck (first day), 11.
Pains and tension in the neck, on moving it (fourth day), 4.
Back.
Tearing in the back, extending to the right shoulder (fourth day), 4.
Pain as if bruised in the back, especially between the shoulders, in the ribs, arms, and legs (first day), 12b.
Dorsal.
The first dorsal vertebræ are painful to pressure with the fingers (fourth day), 7.
Pain in the back, between the shoulders, during the forenoon (fourth day), 7.
Lumbar.
Pain in the small of the back (sixth day), 8. [220.]
Bruised sensation in the small of the back (sixth day), 11b.

EXTREMITIES IN GENERAL

Objective.
Trembling of the limbs (seventh day), 8.
Trembling of the limbs, and weakness, 6.
Trembling of the limbs, with great muscular weakness (seventh day), 8.
Subjective.
Limbs go to sleep in every position (sixth day), 8.
Great weariness and bruised sensation in all the limbs (fourth day), 5.
Sensation of internal lightness of the limbs (first day), 5.
Pains and drawings in the limbs, 3.
Drawings in the arms and in the bones of the extremities generally (for two months), 11b.

SUPERIOR EXTREMITIES

Objective.
Involuntary twitching motion of the second and third fingers of the left hand (ninth day), 11b. [230.]
The arms become heavy, 13.
Subjective.
Spasmodic pain in the right hand, here and there, felt on moving the fingers or hands (ninth day), 11.
Bruised pain in the arms, at the insertion of the deltoid muscle; the coats could scarcely be borne on the shoulders (ninth day), 11b.
The arms at the region of the insertion of the deltoid muscles pain as if bruised (fourth day), 11b.

INFERIOR EXTREMITIES

Objective.
When standing, the legs give way, 13.
Subjective.
Great lassitude in the thighs, in the evening (first day), 12.
Great weakness of the feet (third day), 7.

GENERALITIES

Objective.
Trembling (third day), 8b.
Weakness (third day), 8b.
Great weakness, 11 ; (third day), 11b ; (seventh day), 8. [240.]
Great weakness, all day (seventh day), 11b.
Great weakness obliged him to go to bed early (sixth day), 10.
Great weakness, in the morning in bed (fourth day), 12.
Great weakness, so that he could scarcely move his feet forward, and was obliged to lie down, in the afternoon (sixth day), 8.
Great weakness, with yawning and stretching of the limbs (second day), 11b.
Great exhaustion and indolence (fourth day), 11.
Syncope, 13.
Subjective.
Weariness and sleepiness (fourth day), 4.
General aching of the whole body (fifth night), 8.
Painful aching over the whole body, especially in the eyes, ears, and genitals (seventh day), 8. [250.]
The same sticking pains as in the first proving reappeared; they seemed this time to extend to the back, around the hypochondrium; disappeared during standing or sitting, but reappeared when lying, or during deep cough, 6.

SLEEP AND DREAMS

Sleepiness.
Sleepiness (third day), 8b.
Somnolence (Berandi, from 20 grains), 13.
Drowsiness, 13.
Quiet deep sleep (first night), 7.
Rather quiet deep sleep, without dreams, lasting much longer than usual, but without being refreshed as usual on waking (first night), 12b.
Sleeplessness.
Sleep uneasy (seventh night), 10.
Uneasy sleep (second night), 8.
Uneasy sleep at night, 8b.
Uneasy, dreamy sleep (first night), 7. [260.]
Restless night, with frequent waking (third night), 7.
Dreams.
Sleep full of dreams, startings up in affright (fourth day), 4.
Grotesque dreams, 13.
Voluptuous dreams and painful erections (seventh night), 11b.
Sleep with anxious dreams (first night), 11.
Nightmare (seventh night), 11b.

FEVER

Chilliness.
Chilliness, soon after eight grains, returning again during the day (sixth day), 10.
Chilliness, especially in the pit of the stomach (third day), 10.
Chilliness in the morning in bed (third day), 10.
Chilliness and chattering of the teeth, the whole day (sixth day), 8. [270.]
Chilliness in the evening, and dry heat, and at night, a sweetish sickly smelling sweat (seventh day), 8.
The symptoms gradually disappear (after five days); on the 15th they reappear, especially the chill, as though she had been dashed with cold water, 7.
Shaking chill, from 10 A.M. till noon, without subsequent heat or sweat (third day), 7.
Heat.
Warmth of the skin, 1.
Burning skin, 13.
Much heat and sweat, especially at night, 6.
Great heat over the body, with great turgescence of the veins, in the evening (sixth day), 10.
Heat of the head (second day), 8b.
Heat in the head, especially about the eyes, with sleepy sensation, so that the lids constantly closed (third day), 4.
Heat of the head at 4 P.M., with cold extremities; at 6 P.M., intense general burning heat, with dryness of the skin (seventh day), 10. [280.]
Constant dry heat of the head, 6.
Heat in the forehead, extending thence over the whole head, at 10 P.M. (sixth day), 8.
Sweat.
Sweat during the night (second night), 11b.
Sweat, with excessive thirst in the night (sixth day), 8.
Slight sweat, 1.
Profuse sweat (third day), 8b.
Skin dry, the veins distended (first day), 12b.
Sweat between the shoulder-blades, in the night, followed by itching, which obliged him to scratch (first night), 11b.
Sweat on the shouldlers after moderate motion (ninth day), 11.

CONDITIONS

Aggravation.
( Morning ), Headache ; on waking, bursting headache; stitches in ribs; in bed, weakness; in bed, chilliness.
( Forenoon ), Water in mouth; pain in back; from 10 o'clock till noon, shaking chill.
( Afternoon ), On waking in open air, headache, etc.; about 3 o'clock, headache returned; pain in forehead, etc.; sore pain in forehead; frontal headache; thirst; weakness; at 4 o'clock, heat of head, etc.; at 6 o'clock, burning heat, etc.
( Evening ), At 9 o'clock, confusion of head, etc.; vertigo; pressive pain in head; chilly; at 10 o'clock, tearing in stomach; at 10 o'clock, urging to stool; lassitude in thighs; chilliness, etc.; heat, etc.; at 10 o'clock, heat of forehead.
( Night ), Roaring in ears; tension in abdomen; on waking, pains in sternum; sweetish sweat; heat, etc.; sweat, etc.
( In bed ), Cutting in abdomen.
( During deep cough ), Sticking pains reappeared.
( After dinner ), Nausea; fulness, etc., in stomach.
( After eating ), Distension of abdomen; sensation in abdomen.
( When lying ), Sticking pains reappeared.
( Motion ), While walking, pain in forehead; sticking in the side.
( Pressure ), Pain in pit of stomach.
( Stepping ), Headache.
( Stooping ), Headache.
Amelioration.
( Forenoon ), Towards noon, confusion of head.
( After rising ), Headache.
( Scratching ), Dragging, etc., in anus.
( During standing or sitting ), Sticking pains disappeared.

Cinchoninum Sulfuricum