CIMICIFUGA.

Cimicifuga racemosa, Ell.

Synonyms , Actæa racemosa, Linn; Macrotys actæoides, Raf.; Botroflus serpentaria, Raf. (Med. Flora).

Nat. order , Ranunculaceæ.

Common names , Blacksnake root, Bugbane, Rattleweed.

Preparation , Tincture of the root.

Authorities.

1 , Dr. T. S. Garden, effects of "full doses," Amer. Med. Recorder, 1823 (from Wibmer); 2 , G. W. Mears, took an ounce of "saturated tincture" in two hours, in divided doses, Hempel's Mat. med., 2, 506; 3 , Chas. H. Burr, proving with fluid extract, 10 drops hourly for fourteen hours, then after twenty-four hours, 15 drops hourly for twelve hours, Inaug. Thesis, Hom. Med. Coll. of Penn., 1858 (from Hempel's Mat. Med., 2, 507); [Original not to be found.]

4 , Dr. H. M. Paine's provings, repeated doses of the tincture, 10 to 40 drops (five different provings), N. Am. J. of Hom., 3, 207; 5 , ibid., proving with the 6th dec. dil.; 6 , Mr. S., proving with tincture, 5 to 20 drops, ibid.; 7 , Mrs. A., proving with daily repeated doses of tincture, 10 to 20 drops, ibid.; 8 , Dr. L. B. Wells, proving with 1st dil. (first day 3 drops, third day 3 drops) ibid.; 9 , Dr. Luther Wells, proving with tincture, 102 drops in seven days, afterward 178 drops in eight days, afterwards 210 drops in seven days; 10 , résumé of provings of Drs. Hill and Douglass, N. Am. J. of Hom., 7, 450, "provings on forty men and six women, medical students, entirely ignorant of what they were taking;" [This résumé would seem to include much of Dr. Paine's provings, many of the groups of symptoms being identical in expression and sequence; Drs. Hill and Douglass furnish no details of dose, nor day-books -EDITOR.]

11 , Dr. Bacmeister's proving with half a teaspoonful of the tincture, Trans. Am. Inst. Hom., 1871; 12 , Mrs. L. B., ibid.; 13 , two girls took repeated doses of the 12th dil., ibid.; 14 , Mrs. L. B. took half a teaspoonful of tincture, ibid.; 15 , Mr. W. took 10 drops of tincture every four hours, Trans. Am. Inst. of Hom., 1872; 16 , Cooper, effects of 1st dec. taken ten days, in a woman of 35, who had not menstruated for fifteen years, M. H. R., 15, 179; 17 , Garrison, poisoning of a pregnant woman by 1 drachm of Squibb's fl. ext., Br. and F. Med.-Chir. Rev., 1869; 18 , Chapman, effects, Elem. of Therap., 1, 357 (1831); 19 , Davis, effects of large doses, Trans. Am. Med. Assoc., 1, 352; 20 , Young, effects of a teaspoonful three times a day for chorea, Am. J. of Med. Sc., 9, 313.

MIND

• Emotional.
• A sort of delirium, with an inclination to run over the subject on which he was reading, 10.
• Half intoxicated feeling, with swimming of the head (after half an hour), 10.
• Miserable, dejected feeling, 10.*
• In afternoon, depression and dulness (second day), 12.
• Anxiety, 1.
• *Feels grieved and troubled, with sighing ; next day, a feeling of tremulous joy, with mirthfulness, playfulness, and clear intellect, 10.
• Intellectual.
• Mind clear (as a first effect), 10.
• Mind dull and heavy, 10.
• Not disposed to fix the attention, 10. [10.]
• No disposed to fix the attention on any subject (second day), 6.*

HEAD

• Vertigo.
• Vertigo, 1, 19.
• Vertigo to such an extent that she could not sit up (after two hours), 17.
• Vertigo, fulness and dull aching in vertex (after ten minutes), 5.*
• Vertigo, impaired vision, dizziness, dulness, with fulness and aching in the vertex, 10.
• Dizziness, dulness in the head (second day), 6.
• General Head.
• Dulness and heaviness of the head and eyelids, as if produced by cold, 7.
• Dulness of the head, and pain in forehead and occiput (fourth day), 5.
• *Dull sensation throughout the head, as though he had been on a "spree," and was getting over the effects, 10.
• Heaviness in head, 10. [20.]
• Heaviness and dulness of the head, 7.
• Heaviness, dulness, fulness, slight dull pain, 10.
• Pains in head and face constant, and very severe, 10.
• Slight pain in the head, 4.
• Slight pain in the head, in the evening, 4.
• Great pain in the head, back, and limbs (after two hours), 17.*
• Severe pains in the head, with much somnolency and coldness (after one hour), followed by warmth (after two hours), 2.
• On waking, had a most distressing pain in the head, with vertigo, flushed face, dilated pupils, and an increase of twelve beats in the frequency of the pulse (after three hours), 2.
• Slight dull pain in head, 4.
• Constant dull pain in the head, particularly in the occiput, extending to the vertex, during the forenoon and part of the afternoon (second day), 4.* [30.]
• Fulness and pressure in the brain (second day), .

Bryonia, 10.

• Parietals.
• Slight pain in left side of head (soon after), 4.
• Fulness on left side, 10. [70.]
• Dull pressive pain in left side of head, 10.
• Occiput.
• Pain extending from the right eyeball through to right side of occiput, slightly affecting the ear, at night, 6.
• The pain in the head seemed to extend over and through the whole brain, producing a distinct sense of soreness in the occipital region, which was much increased by motion (15-drop doses), 2.*

EYE

• *During the headache the eyes were so congested as to attract the attention of every one, although there was no disagreeable feeling in them, 10.
• Heaviness of the eyes, as if caused by cold, 7.
• Eyes feels as if swollen, 10.
• Aching of the eyes at 10 A.M. (fourth day), 5.
• Dull aching pain in eyes (fourth day), 15.
• Brow.
• Pain over the eyes (second day), 6.
• Pain over left eye, extending along the base of the brain to the occiput (second day), 4. [80.]
• Severe pain just over right eye, 10.
• Acute pain over left eye; in forehead, occiput, vertex, etc., in paroxysms; pain relieved by the open air, 10.
• Shooting pain over left eye (fourth day), 15.
• Lids.
• Inflammation of both eyelids (second day), 4.
• During afternoon, pain in right eyelid when closing it, 4.
• Sensation of swelling of right eyelid, with heat, as if inflamed (after four hours), 4.
• Stinging in the eyelids (after one hour), 7.
• Stinging and inflammation of the lids, 10.
• Ball.
• Pain in the eyeballs, 10.*
• Pain in both eyeballs (fifth day), 4.* [90.]
• Pain in the centre of the eyeballs, and also sensation as if pain were situated between the eyeball and the orbital plate of the parietal bone , in the morning on rising, continuing all day, but not so severe as in the morning (second day), 4.*
• Eyeballs occasionally painful for a short time, 7.
• Eyeballs painful for a short time in the forenoon (second day), 7.
• Pain in the eyeballs continued for two weeks after discontinuing the drug, 7.
• Dull pain in both eyeballs, 4.
• *Aching pain in both eyeballs , through the day (fourth day), .

NOSE

• Objective.
• Sneezing, 7.
• Sneezing at 4 P.M. (fourth day), 5.
• Sneezing several times (after half an hour), 5.
• Frequent sneezing and fluent coryza, during the day (second day), 4.
• Obstruction of left nostril, in evening, 4. [110.]
• After pain in the head, which continued ten days, coryza, sore throat, and extension to bronchial mucous membranes, 10.
• The pain in the head was followed by coryza, with sore throat and a gradual extension of the disease to the bronchial mucous membrane, dry, short, and hacking cough, night and day, continuing two weeks, which is uncommon, the prover not having had a catarrh or cold for several years, 8.
• Constant coryza during the day, 4.
• Smarting and burning coryza relieved, 10.
• Fluent coryza (third day), 5.
• Fluent coryza of whitish mucus, during the day, 4.
• Fluent coryza, aching, and soreness in the nose, during the day (second day), 4.
• Fluent coryza, more so than for many weeks, as if caused by cold, at 4 P.M. (fourth day), 5.
• Abundant watery coryza, 4.
• Copious coryza (fourth day), 4 ; (fifth day), 5. [120.]
• Copious coryza during the forenoon (fifth day), 4.
• Profuse coryza in the forenoon; aching pain in the head; pain in both eyeballs many times through the day (third day), 4.
• Very profuse, greenish, and slightly sanguineous coryza, 10.
• Very profuse, greenish, and slightly sanguineous coryza, after rising (fourth day), 5.
• At first, dry, stuffed condition of the nostrils, which was soon followed by an open, moist condition, with great sensitiveness to the cold air, as if the base of the brain were laid bare, and every inhalation brought the cold air in contact with it; this is exactly similar to that produced by a sudden change of weather in winter, from cold and dry to damp thawing, as by a south wind, which melts the snow, 10.
• Subjective.
• Inclination to sneeze, twice in the afternoon, .

FACE

• Face flushed (after three hours), 2. [130.]
• Redness of face and eyes, 10.
• Very severe pain in face, more in under jaw, lower teeth, and articulation of lower jaw, 10.
• Cheeks.
• Pain in right superior maxillary bone and teeth, 10.
• At 10 A.M., feeling of lateral expansion and pressure outward in both malar bones and forehead, 11.
• Lips.
• Dry lips (second day), 4, 7.
• Dry sore lips, 10.
• Dryness and soreness of the lips, 4.
• Jaws.
• Severe pain in left jaw, 10.

MOUTH

• Teeth.
• Thick mucus on teeth, 10.
• Accumulation of thick mucus upon the teeth (second day), 4. [140.]
• During afternoon, peculiar uneasiness in teeth; wants to chew or pick at them, 14.
• Tongue.
• Swelling of back part of tongue, 10.
• Roots of tongue and fauces swollen, 10.
• Mouth in General.
• Mouth dry in morning, 10.
• Dryness of lips and mouth, 10.
• Palate and uvula red and inflamed, 4, 10.
• Saliva.
• Increased flow of saliva immediately, 10.
• Spitting of thick saliva, which seemed to stick to the mouth and throat, and to be detached with difficulty, 10.
• Taste.
• Unpleasant taste, 10.
• Unpleasant taste in mouth (15-drop doses), 3 ; (second day), 4, 7.

THROAT. [150.]

• Throat dry, 10.
• Dryness and soreness of throat on swallowing and on pressure, worse on left side, 10.
• Fulness of throat and vertex, and stiffness of neck, 10.
• Sensation as if the throat was partly filled, as low as the top of the sternum, 10.
• *Throat sore, 16.
• Sore throat, when swallowing, 10.
• Soreness of throat when swallowing; sensation of fulness high up in throat, with fulness in vertex and stiffness of neck, in evening, 4.
• Sensation of rawness in throat, 10.
• Sensation of rawness in throat; slight difficulty in swallowing; hoarseness, which increased towards night; constant unpleasant fulness in pharynx, 4.
• Irritation of throat with expectoration of mucus for half an hour, resulting in the cure of an existing cold, 10. [160.]
• Roughness and dryness of the throat, with thirst, 10.
• Uvula.
• Inflammation of the uvula and palate, more severe than the day before (fifth day), 5.
• Fauces, Pharynx, and Œsophagus.
• Increased secretion of thick viscid mucus in the fauces, 3.
• Dry pharynx, 10.
• Dryness of the pharynx, and inclination to swallow, during the night (fourth day), 5.
• Dryness of the pharynx at 4 P.M. (fourth day), 5.
• Fulness of pharynx, and inclination to swallow, 10.
• Fulness of the pharynx, and constant inclination to swallow (fourth day), 5.
• Constriction of the pharynx, with increased secretion of mucus in the throat, 3.
• During forenoon, sense of empty aching all along œsophagus (second day), 11.

STOMACH

• Appetite. [170.]
• Loss of appetite (second day); experienced during the last few days of the proving, and continued for two weeks after, 4.
• No appetite for supper; repugnance to food (second day), 6.
• Desire for tobacco decidedly weakened (second day), 11.
• Thirst.
• Thirst, but no desire to drink, 10.
• Eructation.
• Eructations tasting of the medicine (immediately), 4, 7.
• Eructations and slight nausea (immediately), 6.
• Eructations, nausea, and loss of appetite, 10.
• Violent eructations, but no relief, 10.
• Nausea and Vomiting.
• Nausea, 1.
• Nausea for fifteen minutes (after half an hour), 7. [180.]
• Nausea with loathing (soon after), 8.
• Nausea and vomiting (during the first twelve hours), 17.
• Nausea and vomiting, 10.
• Nausea, vomiting, and much gastric irritation in females , while in males it was hardly noticed as affecting the stomach in the least, 10.
• Nausea all through the abdomen, followed by a loose stool, accompanied by sharp pain in abdomen and considerable downward pressure in rectum (after two hours), 14.
• Some nausea, followed by greater freedom of expectoration and more or less relaxation of the surface, with slight nervous tremors and vertiginous affections, 18.
• Slight nausea and burning of the stomach, 10.
• Slight nausea, with weak, trembling, exhausted feeling, 10.
• Slight nausea, which increased with a sickening pain in the duodenum; half an hour afterwards, flatulence, eructations, and more nausea; a second dose increased the symptoms with general feeling of illness; supper abated the bad feeling, but nausea returned soon after, 10.
• Awful nausea, with tremors all over, . [190.]

ABDOMEN

• Hypochondria.
• Pain in left hypochondria region, worse on motion and on taking a deep inspiration, 10.
• Dull pain in region of liver, 10.
• Umbilical.
• Rumbling of flatus below the umbilicus at 10 P.M. (fourth day), 5. [210.]
• Dull griping-twisting at the umbilical region, more towards the left, 10.
• Acute cutting pain at the umbilicus, 10.
• Acute cutting pain in the umbilical region, which, although acute, was not so severe as to prevent attending to his usual business; uninfluenced by eating, and continuing through the afternoon (after three hours), 4.
• General Abdomen.
• Flatus, 10.
• Flatulence, 10.
• Flatulence, causing a sensation of fulness in the abdomen, at 10 P.M. (fourth day), 5.
• Pain in the abdomen, 10.
• Wandering pains in bowels, 10.
• Dull, heavy pains in the abdomen, 10.
• Fulness, pressure in abdomen, 10. [220.]
• Griping pains in bowels, from the umbilicus down, 10.
• Periodic colic, with inclination to bend forward, relieved after stool, 10.
• Soreness of abdominal muscles on taking a full inspiration, 10.
• Hypogastrium and Iliac Regions.
• Flatus; rumbling in lower part of abdomen at 10 A.M. (fourth day), 5.
• Rumbling in lower abdomen, 10.
• Fulness and pressure in lower part of abdomen; increased pressure next day, with some pain, 7.
• Soreness in lower abdomen (second day), 12.
• Slight pain in left iliac region; afterwards, severe pains in bowels, mostly below the umbilicus with weight and pain in lumbar and sacral regions, 10.

RECTUM AND ANUS

• Disposition to diarrhœa, 10.
• Disposition to diarrhœa, in the evening, 4. [230.]
• Slight disposition to diarrhœa, 4.
• Slight disposition to diarrhœa, after rising (second day), 4.
• Urging to stool, inclined to diarrhœa, 10.

STOOL

• Diarrhœa.
• Scanty diarrhœa, with tenesmus (fourth dose), 10.
• Two copious papescent stools in morning, 10.
• Copious papescent stool in morning, 10.
• Large papescent stool, with general indisposition (after second dose), 10.
• Constipation.
• Fæces hard and dry, 10.
• Constipation, 3, 10.
• *Evacuations natural during provings, but alternate constipation and tendency to diarrhœa for a month after, 10. [240.]
• Evacuation regular and natural during the proving, but for a month afterwards, alternate constipation and tendency to diarrhœa, 4.

URINARY ORGANS

• Urethra.
• Violent stitches in urethra in morning, 10.
• Disposition to frequent urination (second day), 7.
• Disposition to frequent urination, with increased secretion, 10.
• Micturition.
• Increased secretion of pale urine, 6.
• Increased flow of urine (second day), 8.*
• Profuse flow of clear watery urine, 10.
• Passes a great quantity of clear urine, which makes her feel very weak, 16.
• During the first of the proving it was necessary to void urine about once an hour, 3.
• Urine scanty and high-colored (fourth day), 15. [250.]
• Retention of urine for eighteen hour, followed by frequent micturition, 10.
• Urine.
• The second specimen showed that from a normal standard the urine in sp. gr. had gone down to 1.005. The following specimen showed that a change was taking place, and the next that it had gone up to 1.019. It soon reached 1.020, at which point it remained. It was collected in a vessel, and allowed to repose till the expiration of twenty-four hours, at which time it was strongly acid to litmus, and to the eye presented a dull cloudy appearance. A closer examination showed that there were thousands of little fibres, about the eighth of an inch in length, which the microscope exhibited as fibrinous casts of uriniferous tubes, (!) with minute lozenge-shaped crystals of uric acid adhering to their sides. On the addition of a few drops of hydrochloric acid quite an abundant deposit was thrown down, which presented the beautiful variety of colors peculiar to these crystals, 3.
• In the vessel could be seen a copious deposit of uric acid in the form of yellow sand, while above it floated a cloud of mucus and the urate of ammonia. The urine above the cloud was filled with floating particles of yellowish sand, which seemed to be gradually settling to the bottom, presenting the appearance of a free admixture of ginger and water. Specimens of the sand were examined by heat, acids, and the microscope, carefully enough to determine that it was uric acid of the nucleated form of crystals, with the obtuse angles rounded so as to make an elliptical figure, 3.
• Urine yielded abundant crystals on the addition of nitric acid; these crystals had the fine satin-like lustre peculiar to the nitrate of urea, and were deposited without previous evaporation of the urine, which indicates that urea was largely in excess, .

SEXUAL ORGANS

• Male.
• Pain and tenderness in testicles, 10.
• Pain and retraction in right spermatic cord, 10.
• Drawing pain along right spermatic cord, 10.
• Female.
• Leucorrhœa and chronic inflammation and congestion of uterus cured during the proving, while no other symptoms were observed on the provers until disappearance of the uterine disease, 10.
• (Leucorrhœa of long standing cured during a week's proving), 10.
• Bruised, sore feeling in vagina (second day), 12. [260.]
• *During menses, very severe bearing-down, forcing pains, 13.
• Labor-pains ceased entirely for thirty-six hours (after two hours), 17.
• Taken unwell in the morning; wandering pain in back and around through hips, inside, lasting all morning, quite severe at 10, when she was obliged to lie down; has never had so much pain during menses; flow more profuse since 5 P.M. (second day), 12.
• Menorrhagia, 10.
• Suppression of menses, 10.

RESPIRATORY ORGANS

• Larynx and Bronchi.
• Constant inclination to cough, from tickling in the larynx, increased by speaking, 10.
• Constant inclination to cough for half an hour, caused by a tickling sensation in the larynx, which almost prevents speaking, at 7.30 P.M.; an attempt to speak is followed by an inclination to cough (fourth day), 5.
• Sensation of slight contraction in the bronchial tubes, which rendered expiration somewhat difficult, after a full inspiration (after six hours), 3.
• Voice.
• Hoarseness (fourth day), 4 ; (after nine hours and a half), 5, 10.
• Hoarseness after rising (second day), 4. [270.]
• Hoarseness, more towards night, 10.
• Hoarseness and roughness of throat, 10.
• Hoarseness, roughness, and scraping in the throat, 10.
• Hoarseness, with roughness and scraping of the throat, 10.
• Hoarseness; unpleasant fulness in pharynx (third day), 5.
• Slight hoarseness (fifth day), 4.
• Cough.
• Dry cough of long standing cured after short irritation of throat and expectoration, 10.
• Dry, short, hacking cough, night and day, for two weeks, 10.
• Slight dry cough four or five times, produced by tickling in larynx (after nine hours and a half), 5.
• Short dry cough, 10. [280.]
• Short dry cough several times during the evening, caused by tickling in the larynx (third day), 5.
• Respiration.
• Offensive breath, 7, 10.
• Offensive breath, 10.
• Decidedly quickened respiration on waking, 10.
• Difficult respiration after slight exertion, with general feeling of illness, 10.

CHEST

• Slight pain in chest, 10.
• Soreness of the chest (second day), 7, 10.
• Lancinating pain along cartilages of false ribs, increased by inspiration, 10.
• Lancinating pain along the cartilages of the false ribs, increased by taking a long inspiration, soon after waking, at 3 A.M. The same pain, very severe and piercing, so as almost to prevent inspiration for a short time, immediately after retiring, between 10 and 11 P.M., and continuing for half an hour, 4.
• Prickling sensations during the day in the (female) mammæ, with cold chills, 7.
• Sides. [290.]
• Pain in the left side of the chest, 10.
• A catching pain in the left side, just where the heart is , which comes on when she bends her body forward, sometimes when sitting still at dinner and after dinner, 16.*
• Acute pain in right lung, from apex to base, to the right of the sternum, aggravated by inspiration, 10.
• Acute pain in right lung, extending from apex to base, about two inches to the right of the sternum, aggravated by every inspiration, continuing for two hours, and gradually diminishing in intensity until after retiring; similar pain next morning, for half an hour, but much less severe (second day), 1.

HEART AND PULSE

• Præcordium.
• Pain in region of heart followed by slight palpitation ; at the sixth hour the pain was felt all the time, and accompanied by frequent paroxysms of palpitation, 3.*
• Stitches in the region of the heart or in the heart, 10.
• Heart's Action.
• Palpitation and faintness, 10.
• Pulse.
• Pulse quick and weak, 10.
• Pulse feeble and accelerated, 10.
• Pulse increased twelve beats (after three hours), 2. [300.]
• *Pulse 70 or 80, irregular (after one hour), 10.
• Pulse ranged at about 80 (15-drop doses), 3.
• Pulse 86, full, hard, and irregular (after twenty minutes), 3.
• Pulse too slow, every third or fourth pulsation intermitting (second day), 4.
• Pulse too slow, every third or fourth beat intermitting, 10.
• Pulse fallen from 78 to 72 (after one hour), 8.
• Pulse went down to 69 (after six hours), 3.
• Depression of the pulse, which remains for a considerable time, 19.
• The pulse is considerably lowered, and is apt to remain so for some time, 18.
• Pulse very weak, with general feeling of lassitude and weakness, with heat and smarting of the face (after third dose), 10. [310.]
• Pulse weaker and very irregular; 80 to the minute (after three-quarters of an hour), 10.
• Feeble pulse (during the first twelve hours), 17.
• In the morning, pulse feeble, with weakness and trembling, 10.
• Pulse small, 1.

NECK AND BACK

• Neck.
• Stiffness of neck, 10.
• Stiffness of neck, in evening, 4.
• *Rheumatic pains in the muscles of the neck and back; a feeling of stiffness and contraction, 10.
• Cramping in the muscles of the neck on moving the head, first in the left, afterwards in the right side, 10.
• Back.
• Trembling and weakness in the back, 10.
• Pain as of boils in the back, small of back, and extremities, 10. [320.]
• Terrible backache (second day), 15.
• Symptoms of the back, etc., felt for several days, 10.
• Backache better from pressure (second day), 12.
• Dorsal.
• Pain below left scapula, 10.
• Occasional slight pain in either scapula and right shoulder, 10.
• Occasional slight pains in either scapulæ and left shoulder, 10.
• Dull pain behind right scapula, 10.
• Dull pain in region of lower dorsal and upper lumbar vertebræ, 10.
• In the morning, on bending the neck forward a severe drawing-tensive pain at the points of the spinous processes of the three upper dorsal vertebræ, which continued for several hours, 10.*
• Drawing pain in a single muscle between the right scapula and spine, for some hours, 10. [330.]
• Stitches in back, a little below the right scapula and spine, 10.
• Lumbar.
• Lame, tired feeling in the back, extending from the region of the kidneys to the sacrum, relieved by rest and increased by motion, 10.
• Weight and pain in the lumbar and sacral regions , sometimes extending all around the body, somewhat below the crest of the ilium, 10.*
• Feeling of weight in the small of the back, .

EXTREMITIES IN GENERAL

• Objective.
• Trembling in the limbs, scarcely able to walk, 10.*
• *Twitching of the fingers and toes (second day), 15.
• Subjective. [340.]
• An "uneasy feeling," amounting to "almost an ache," through all the extremities every time she took it, which would continue from one to three or four hours, 20.*
• Pains in the extremities, 1.
• Pain in the extremities, as of boils, with fulness of the head on left side, 10.
• Restless, drawing sensation in the extremities, 10.
• Pain in all the limbs (second day), 15.
• Rheumatic pains in the muscles of the arms and legs, of a drawing character, 10.
• Pain in right arm, elbow, wrist, and in the knee, extending down to the ankle, 10.
• In morning, his joints felt, on motion, as if he had labored exceedingly hard the previous day; joints felt stiff for a day after, 10.

SUPERIOR EXTREMITIES

• Severe pains in the arms, with a numbing sensation, as if a nerve had been compressed. There pains were first felt in the shoulder, and passed down the arm, and then the forearm, producing a very peculiar lame, numb, and sometimes cramping sensation. Similar pains in the legs, but more severe and constant in the upper part of the thigh, about the hip-joint and inguinal region. Slight rheumatic pains all next day, 10.
• Dull pain in the right arm, in the muscles, from the shoulders to the wrist, 10. [350.]
• Dull pain in right arm, deep in the muscles, extending from the shoulder to the wrist, continuing during the next day, 6.
• Elbow.
• Laming, aching pain in left elbow-joint, anteriorly, 11.
• Wrist.
• Lameness of left wrist, 10.
• Pains in wrist and right elbow, which had continued all day, were relieved, 10.
• Hand.
• Hands and forearms weak and trembling; cannot grasp anything firmly; later, hands and feet cold as death, with general chilliness, 10.
• Fingers.
• Trembling of the fingers when writing, 11.*
• Lameness and inability to flex the second finger of left hand, 10.

INFERIOR EXTREMITIES

• Rheumatic pain in left leg, 10.
• Thigh.
• Constriction of left sartorius muscle, 10.
• Knee.
• Rheumatic pain in knee-joint, 10.
• Leg. [360.]
• Lameness in right leg, worse when bending forward; soreness and stiffness moved forward to inside to ankle (second day), 12.
• While walking out of doors, sense of aching and shortening in the tendo Achillis (left leg), (second day), 11.
• Towards evening, soreness, aching, and stiffness in region of tendo Achillis, aggravated by walking (second day), 14.
• Ankle.
• Sharp wandering pains in left ankle and scapula (after twenty minutes), 3.
• Excruciating pain in left external malleolus and left forearm, 10.
• Foot.
• Feeling in foot as if it had been compressed, 10.
• Toes.
• Pain in right great toe (second day), 15.
• Dull aching-burning pain in second joint of right great toe, 10.*
• Dull burning-aching pain in second joint of right great toe, extending up the limb , continuing an hour, from 8 to 9 P.M. The same pain at the same time the next evening, but not extending up the limb. The same pain, less severe, on the third evening, 4.
• Stinging of left great toe for a few moments on the lower surface, and afterward on the upper, in the afternoon, 7.

GENERAL SYMPTOMS

• Objective. [370.]
• *Nervous shuddering through upper and back part of body, 11.
• Very trembling, 11.
• *Tremors all over (after third dose), 10.
• After going to bed, jerking commenced on the side on which he was lying, obliging him to change his position ; it began by a perceptible twitching in the left foot, 10.*
• Easily fatigued, as after great exertion, 10.
• Weak, trembling, exhausted, sinking feeling, with slight nausea, 10.
• Nervous weakness, afternoon, 10.
• Prostration (during the first twelve hours), 17.
• Restlessness.
• Restlessness, 1.*
• Restlessness, afternoon, moving about, not knowing what to do, 10. [380.]
• Continual restlessness during the forenoon; desire to move about, not knowing where to go, or what to do, 6.*
• Restless the latter part of the night, 10.
• During night, very restless, 6.
• Nervous uneasiness , during the afternoon (second day), 6.*
• The general uneasiness and disturbance in the whole system was such that it was difficult to fix the attention on any subject of business or study, 3.*
• Uneasy feeling, hardly amounting to pain, in all parts, principally the right side, 10.
• All day nervous, full of work, and doing it fast, 11.
• Sensibility.
• Sensitiveness to cold air, 10.
• Great sensitiveness to cold air, which seemed to penetrate the system (second day), 6.
• Subjective.

SKIN

• Eruptions, Dry.
• Small red papillæ first appeared, becoming a diffused redness, 10.
• Eruptions, Pustular.
• Single pimples on the back of the hand, with a little pus at the apex, 10.
• In morning, soon after rising, observed a single pimple on dorsal surface of left hand, it was larger, but similar in appearance to those produced two months since; a little pus secreted at its apex; after three or four days it disappeared (second day), 4.
• Ulcers.
• Ulcer on inner surface of lower lip, 10.
• Small ulcer on inner surface of lower lip, 4.
• Subjective. [410.]
• Itching of the back of the hand and wrist, 10.
• Itching and redness of the back of the hand, 10.
• Itching and redness of the dorsal surface of the right hand, in the afternoon, and especially in the evening, 4.
• Itching of the dorsal surface of the left hand and wrist, particularly on the dorsal surface of the thumb, in the evening; small red papulæ first appeared, becoming, after slight irritation, a diffused redness, which disappeared in a few hours, but could be reproduced at any time by slightly irritating the surface; this symptom gradually disappeared in a few days, 4.

SLEEP AND DREAMS

• Sleepiness.
• Very sleepy (second day), 15.
• In afternoon, felt as if he could not keep awake, but must lie down and go to sleep, 15.
• Drowsiness, with creeping chills upon the back, during the evening, followed by frequent wakings during the night, and desire to throw off the bedclothes, although the thermometer was below zero, 10.
• So drowsy that he laid down and soon feel asleep, and remained in this state an hour (after two hours), 2.
• Sleeplessness.
• During the night, slept well for three or four hours, then restless, 4.
• Sleep very restless, 10.* [420.]
• Disturbed, restless, unrefreshing sleep from 3 to 5 A.M., with disposition to fold the arms over the head (second day), 4.
• Frequent wakings during the night, and a copious, papescent stool in the morning, 1.
• Frequent wakings during the night, during some of which there were flushes of heat, and desire to throw off the bedclothes, when the thermometer was below zero, 10.
• Cannot sleep at night (fourth day), 13.
• Dreams.
• Troublesome dreams, 10.
• Unpleasant dreams of being in trouble, of being in a sad plight, 4.*

FEVER

• Surface of the body, together with that of the face and hands, became cool and dry (after six hours), 3.
• Chilliness in the forenoon, 10.
• Afternoon chilliness (second day), 12.
• Cold chilliness, with cold hands and feet, 10. [430.]
• Chilly, in bed before rising (third day), 15.
• General, internal, nervous, chilly feeling all over, but less over the back, 11.
• Cold chills, with pricking sensation in the breasts, 7.
• Cold chills and prickings in the female mammæ, 10.
• Occasional cold chill, 7.
• Coldness and chills, especially of the arms and feet, 10.
• Soon after waking, in morning, whole surface became cold, 10.
• Soon after waking, at 3 A.M., the whole surface became cold; slight cold perspiration, and sensation as if it would become profuse, continuing for an hour, accompanied by lancinating pain along the cartilages of the false ribs left side, increased by taking a long inspiration (second day), 4.
• During afternoon, chilliness in back, 14.
• Heat.
• Heat in front part of head, 10. [440.]
• Heat in left side of face, with lassitude all over, 10.
• Increased heat of face; slight inclination to sweat; pulse rather full, and 90 in the minute, it being nearly 80 before taking the drug (after three-quarters of an hour), 10.
• Flashes of heat in cheeks, 11.
• Heat, pain, and weariness in the region of the kidneys (second day), 3.
• Sweat.
• Disposition to perspire at night, for three weeks, 10.
• Perspiration, headache, similar to morning sickness during pregnancy, etc., 10.
• Slight cold perspiration, with lancing pain along cartilages of false ribs, increased by inspiration, 10.
• Skin dry and hot, 3.
• Cold sweat on hands and feet (third day), 15.

CONDITIONS

• Aggravation.
• ( Morning ), On waking, pain in head; on getting up, dull headache; before breakfast, pain in forehead; on waking, at 2 o'clock, pain in forehead, etc.; after rising, pains in vertex, etc.; on rising, pain in eyeballs, etc.; after rising, coryza; dry mouth; before eating, faintness at epigastrium; before breakfast, pain in epigastrium, etc.; after breakfast, sense of tremor in stomach; after rising, disposition to diarrhœa; papescent stools; stitches in urethra; on waking, quickened respiration; on bending neck forwards, pain at points of spinous processes of vertebræ; early, pain in small of back; feeling in joints; from 3 to 5 o'clock, disturbed sleep, etc.; in bed, before rising, chilly; soon after waking, surface cold.
• ( Forenoon ), At 9 o'clock headache; at 10 o'clock, aching of eyes; eyeballs painful; coryza ; at 10 o'clock, feeling in malar bones, etc.; sense of aching along œsophagus; faintness in epigastrium; at 10 o'clock, rumbling in abdomen; restlessness; chilliness.
• ( Afternoon ), Depression, etc.; pain in head; dull pain in forehead; pain in eyelid; at 4 o'clock, sneezing; inclination to sneeze; uneasiness in teeth; at 4 o'clock, dryness of pharynx; sensation in stomach; towards evening, soreness, etc.; in region of tendo Achillis; stinging of great toe; nervous weakness; itching on hand; chilliness; chilliness in back.
• ( During forenoon and part of afternoon ), Dull pain in head.
• ( Evening ), Pain in head; at 10 o'clock, pain in forehead, etc.; fulness in vertex; after retiring for the night, pain in eyeball; obstruction of nostril; stinging in nose; sore throat; towards night, hoarseness; at supper, no appetite; at 10 o'clock, rumbling of flatus; at 10 o'clock, flatulence; disposition to diarrhœa; dry cough; stiffness of neck; from 8 to 9 o'clock, pain in great toe , after going to bed, jerking; feeling of lameness, etc.; itching, etc., on hands; drowsiness.
• ( Afternoon and evening ), Pain in vertex.
• ( Night ), Pain from eyeball through occiput; dryness of pharynx, etc.; restlessness; disposition to perspire.
• ( Bending forward ), Lameness in leg.
• ( After hearty dinner ), Frontal headache.
• ( Inspiration ), Pain along cartilages of hips; pain in lung; pain in hypochondriac region.

SUPPLEMENT: CIMICIFUGA. Authority.

21 , Inaug. Thesis, presented to Hom. Med. Coll. of Penna., 1853, by Franklin Bigelow.

The tincture used in the following provings was made from the dried root gathered in the spring.

First Prover.

Mr. F. B., aged twenty-five years.

September 29th, 1852. Took 25 drops of the tincture at 3 P.M. At 10 A.M., next day, a dull oppressive headache came on; pain principally in the forehead, extending along over the vertex down to the occiput. In the whole forehead the pain is very severe. On walking out into the open air, pains in the muscles of the lower limbs as from great fatigue; felt more particularly in the anterior parts of the thighs. Great disposition to yawn. Inclined to drowse much. Sleep disturbed by dreams of accidents, seeing limbs broken, great suffering, etc.

On the following morning awoke at 3 o'clock, with severe cutting pains and great uneasiness in the lower part of the abdomen (hypogastric region), with urgent desire to go to stool. Stool very thin and partly undigested. Great uneasiness in the bowels all the forenoon, without much desire to go to stool, but a sensation as though I should be obliged to soon. Next morning awoke at 3 o'clock, with diarrhœa of thin undigested character. Pain low down in the bowels. Diarrhœa continued through the day; stools once in four or five hours.

Next day no perceptible symptoms remained except a feeling of weakness and languor.

Second Proving.

October 7th, 11 A.M. Took 100 drops of the 1st atten. (5 to 95). Great nausea and disposition to vomit for two hours after taking it. Very sleepy during the forepart of the evening. Slept well till 3 o'clock in the morning; very restless the remainder of the night.

October 8th. At 6 A.M., dull oppressive headache came on, extending from the forehead over the vertex to the occiput; violent pain in the whole forehead; pain dull , with a sense of heaviness. Great dizziness. Constant disposition to yawn. Occasional shooting pains about the sides of the head, in the region of ideality and sublimity. Pulse rather accelerated. Feeling of great prostration of whole system. Appetite poor. Limbs feel excessively fatigued. Forehead dry and hot. Pains in head partially relieved by throwing head backward. At times very chilly over the entire body. Continually stretching and yawning. Great uneasiness and oppression in the epigastrium. Stomach feels greatly oppressed. On attempting to read immediately go to sleep. Disposed to get angry easily. Rather melancholy. Symptoms nearly all subsided by 2 P.M. In the evening great pain in lower part of bowels, with great fulness of the abdomen. Sensation as though diarrhœa would come on. Very bitter and disagreeable taste in mouth: Very drowsy and sleepy. Slept well till 3 A.M., after that time very restless. This symptom appeared regularly every morning for two weeks.

Second, third and fourth days after 3 A.M., each day, pain in lower part of bowels, with diarrhœa of a thin, undigested character, lightish-colored. Pains in the head grew less and less severe for three or four days, and gradually subsided by the fifth. Upper lip very much swollen and inflamed for eight days. Skin cracked and came off. A small ulcer on each cheek, near the centre; very much inflamed for several days, bleeding almost constantly. Eruption, on the hands and wrists principally, resembling mosquito-bites.

Second Prover.

Mr. E. H. B., aged twenty-four years.

September 29th, 1852. Took 20 drops of the tincture at 9 A.M. One hour after, fluent coryza, with violent tickling in the nares, which excited sneezing, going off in about half an hour. Great drowsiness after dinner. Weakness of the knee-joints, preceded by unnatural warmth in the feet. Weakness in the lower limbs. When walking, have to proceed with great cautiousness for fear of falling.

General feeling of intoxication . Dull, heavy rheumatic pains in the upper posterior region of the neck. Tearing in the centre of the vertex, in a spot about the size of a silver dollar. Jerking in the muscles of the left thigh, more particularly in the region of the inferior third. Cold feeling of the left thigh and knee, as though a cold breeze were blowing on them. Stitching pain as of fine needles in the region of the heart, accompanied with slight twitching or pulsation in the external muscles of that region. Slight palpitation of the heart. Sleep imperfect; waking at midnight. General burning and itching of the skin after rising in the morning, continuing half an hour.

Third Prover.

Mr. E. P. G., aged eighteen years.

September 29th. Took 20 drops of the tincture at 10 A.M. Soon after taking it, burning in the stomach and excessively bitter taste in the mouth: Half an hour after, felt a sensation of rawness in the throat, as from excoriation. One hour after, dull pain in the forehead and ears.

Third day, early in the morning, pain in the bowels, with thin, light-brown diarrhœa, which came on in like manner for three or four days. Eruption on the skin like mosquito-bites, 21.