Lycopus
By Timothy F. Allen — The Encyclopedia of Pure Materia Medica
Lycopus Virginicus, Linn.
Natural order , Labiatæ.
Common name , Bugle Weed.
Preparation , Tincture of whole plant.
Authorities.
1 , Dr. N. S. Davis, effects in a healthy person of a wineglassful of the infusion every two or three hours, Trans. Amer. Assn., 1, p. 348 (1848); 2 , Dr. G. E. Chandler, Hale's N. R., took 10 drops of tincture at 10 P.M. (first day), 11 drops at 7 and 12 A.M., 5 and 10 P.M. (second day), 12 drops an hour before each meal and on retiring (third day), 13 drops four times, as yesterday (fourth day), 14 drops four times, as yesterday (fifth day), 15 drops four times, as yesterday (sixth day); a month later discovered a peculiar beat of the heart, the first sound displaced by a blowing sound; five days after this, took 15 drops at 5.30 P.M. (first day), 15 drops at 9 A.M. (second day), 20 drops at 8 A.M. and 30 drops at 11.30 P.M. (third day), 50 drops at 8 A.M. (fourth day), 20 drops of 1st dil. at 8 A.M. and 11 P.M. (seventh day); 3 , Dr. Morrisson, Month. Hom. Rev., 16, 737, [Health usually good, though not robust; for last nine years tendency to rheumatic pains, with slightly depressed cardiac action; oppression of crowded rooms induces faintness; for about a week tendency to diarrhœa; slight attacks of spasm of the intercostals, which have troubled me for about a month, consequent on effects of arsenical wall-paper; depression of vital energy from long strain of work. Impulse of heart rather feeble; percussion shows that the heart is of natural size; there is a distinct systolic basic murmur heard at the second left interspace, which I have no doubt is hæmic; the first sound at the apex is not good, and rather murmurish; occasional intermissions in the heart's beats. Pulse 70 (sitting); temperature 36.40° C.; respiration 20. Urine clear, bright (even after standing the whole night); acid; sp. gr. 1012; free from albumen.] with sphygmographic tracings, took 10 drops of tincture 10 P.M. (first day), 10 A.M. and 2 P.M. (second day), 15 drops at 10 P.M. (second day), 20 drops at 10 A.M., 2 P.M., and 10 P.M. (third day), and 10 A.M. (fourth day), 30 drops at 2 P.M. (fourth day), also 9 A.M. and 10 P.M. (fifth day), and 10 A.M. (sixth day), 40 drops at 10 P.M. (sixth day), and 10 A.M. (seventh day), 50 drops at 11 A.M. (eighth day), 10 A.M. (ninth day), and 10 A.M. (tenth day), 80 drops at 11 A.M. (eleventh day), 100 drops at 10 A.M. (twelfth day), 120 drops at 10 A.M. (thirteenth day), 3 drachms at 10 A.M. (fifteenth day), 4 drachms at 10 A.M. (seventeenth day); 3 a , same, Month. Hom. Rev., 18, 620, proving with the 200th dil., one dose; 3 b , same, second proving with 200th dil., doses on first, third, and tenth days; 3 c , same, third proving with 200th dil., one dose.
MIND
- Slight obtusion of intellect, with dull aching through sinciput (after second dose, third day), 3.
- Difficulty in concentrating attention and thought (tenth day), 3b.
- Lost more or less control of my mind, it being wandering from one thing to another, during the proving, 2.
HEAD
- Vertigo.
- Giddiness (third day); even while sitting (fourth evening), 3a, 3b.
- Giddiness, with tendency to stagger to the right, in the forenoon (seventeenth day), 3.
- Giddiness, with tendency to stagger to the right, before retiring (fifteenth night), 3.
- Giddiness, with tendency to stagger to the right (thirty-second day), 3.
- Giddiness, with tendencies to stagger right and forward (tenth day), 3b.
- Persistent giddiness while sitting, with staggering to right on walking, succeeding the nausea, in the evening (sixteenth day), 3. [10.]
- Persistent giddiness, commencing when walking in the open air, continuing after entering the house, while sitting, at 7 P.M. (twenty-third day), 3.
- Tendency to bear to the right in walking (first day), 3a.
- General Head.
- Frontal and vertical portion of the head dull and pressing out at 8 A.M. (fourth day), 2.
- Severe, general headache, lasting several hours, in the afternoon (twenty-fourth day), 3.
- Severe, general headache, with giddiness, in the evening (eighteenth day), 3.
- Fronto-occipital headache, with toothache (after one hour, thirteenth day), 3.
- Severe fronto-occipital headache, from 3 to 7 P.M., succeeded by labored cardiac action (twenty-fifth day); slight return of headache at 3 P.M. (twenty-sixth day), 3.
- Slight pressure in head and eyes in the evening (thirteenth day), 2.
- Pressive cephalalgia during evening (fourth day), 3b ; before rising was free from headache, which immediately slightly returned; not relieved by cold affusion; headache increased (after first dose, seventh morning), 3. [20.]
- Dull, oppressive headache at noon (seventeenth day), 3.
- General oppression of brain in forenoon (seventeenth day), 3.
- Oppressed feeling in brain, succeeded by subacute pain an inch below and to outer side of left nipple, quickly subsiding (five minutes after second dose, second day), 3.
- Acute darting from anterior superior angle of left parietal to malar bone at 2 P.M., succeeded by sensation as if the brain were compressed, followed by long-continued irritation of scalp over the line of pain (twentieth day), .
EYE
- Eyes feel weak, as if the system were much overfatigued (after six hours, seventh day), 3.
- Some pain in eyes and front head, but not constant (eleventh day), 2.
- Eyes full and heavy through the day (seventh day), 2.
- Eyes full, painful, and pressing outwards, in the morning (second day), 2.
- Constant pressure in the eyes and front head at 3.15 P.M. (twelfth day), 2. [80.]
- Slight pressure in eyes and head in the evening (thirteenth day), 2.
- The eyes press out (four hours after first dose, third day), 2.
- Brow and Orbit.
- Dull pain in the left supraorbital region, of several hours' duration, at 3.30 P.M. (fourth day), 2.
- Neuralgic pain in right supraorbital region and in left testicle (thirty-second day), 3.
- Aching pain above left orbit (second day), 3b.
- A quite marked pressing pain in the supraorbital region but a few minutes (five hours after second dose, second day), 2.
- Ball.
- Painful pressure in the eyeballs at 8 A.M. (eighth day), 2.
EAR
- Burning of the right ear, lasting an hour or more (after four hours, fourth day), 2.
NOSE
- Sneezed violently once on waking (third and fourth mornings), 3b.
- Slight nasal catarrh, with sneezing (ninth day), 3b. [90.]
- Catarrhal sensation in left ala nasi, of short duration (seventh day), 2.
FACE
- Parched feeling in upper lip in the forenoon (seventeenth day), 3.
- Aching in left inferior maxillary articulation and in left wrist, at 10.30 A.M. (sixteenth day), 3.
MOUTH
- Teeth.
- Pain in lower molars transferred to right (after ten minutes, eighth day), 3.
- Tendency to toothache, first in right molars (sound teeth), then transferred to left (sound teeth), (thirteen hours after first dose, fifth day), 3.
- Tendency to toothache in right lower molars (sound teeth), succeeded by subacute pain, first in left then right frontal eminence (five hours after second dose, fourth day), 3.
- Slight pain in molars, passing from right to left, in the evening (ninth day), 3.
- Aching in right upper molar (sound tooth), lasting several minutes, immediately (first day), 3b.
- Continuous aching in left lower molars (seventeenth morning), 3.
- Slight aching in left lower molars (sound teeth) in the evening (twelfth day), 3. [100.]
- Slight achings in left lower, left upper, and in right upper molars (decayed teeth), (second day), 3a.
- Severe aching in left lower molars (sound teeth), spreading to left upper bicuspids (sound teeth), lasting several hours, after rising, succeeded by frontal headache (twenty-first morning), 3.
- Severe and continuous aching in left lower molars (sound teeth) during the day (nineteenth day), 3.
- Acute aching in right lower molars (decayed), (after five minutes), 3c.
- Sharp pain in right lower molars, passing to right temple, then to left lower molars, then to left temple, then returning to right lower molars, then settling in loins, with frontal oppression (after half an hour, eleventh day), 3.
- Sharp aching in left lower molars (sound teeth), (thirteenth day), 3.
- General Mouth.
- Burning in usual spot of palate, following frontal headache (fifteen minutes after first dose, fourth day), 3.
- Slight burning in palate (five minutes after second dose, third day), 3.
- Slight burning on right side of palate in usual spots (after third dose, third day), 3.
- Slight burning on right side at back of palate, lasting fully ten minutes, succeeding the pain in the frontal eminences (first day), 3. [110.]
- Sharp pain in usual spot of palate, lasting several minutes (one hour after first dose, fourth day), .
THROAT
- Fauces and Pharynx.
- Irritation in fauces, inciting to cough, during evening (fourth day), 3b.
- Subacute pain in pharynx increased by deglutition (half an hour after second dose, fifth day), 3.
- Strange sensation extending up œsophagus and locating in pharynx (twelve hours after first dose, fifth day), 3.
- External Throat.
- Painful stiffness in left inframaxillary region, extending to nape of neck, interfering with movement of head, in the afternoon (thirteenth day), 3.
- Pain, steady and deep, in the right parotid gland and at the angle of the right maxillary (after four hours, fourth day), 2.
STOMACH
- Nausea. [120.]
- Slight nausea, during evening (fourth day), 3b.
- Persistent nausea, rising from back of fauces, relieved by eructations, which taste of tea and drug, succeeded by persistent giddiness while sitting, with staggering to right on walking, in the evening (sixteenth day), 3.
- Slight nausea, with faintness, when walking in the open air, at 7 P.M. (twenty-third day), 3.
- Slight return of faint nausea, in the evening (fifteenth day), 3.
- "Heart sickness" (faint nausea), lasting an hour, not relieved by dinner (after three hours and a half, fifteenth day), 3.
- Eructation.
- Eructations, with distinct flavor of the drug (after half an hour, tenth day), 3b.
- Stomach.
- A circumscribed pain and compression in the epigastric region (after three hours and three-quarters, fourth day), 2.
- Stitchlike pain in the cardia, causing an exclamation (four hours and a half after first dose, third day), 2.
- Throbbing pain in the cardiac, at 3.15 P.M. (tenth day), 2.
ABDOMEN
- Hypochondria.
- Tenderness in the left hypochondrium (fourth hour after first dose, third day), 2.
- Lugging pain in the spleen, of several hours' duration, at 9.45 P.M. (twelfth day), 2.
- General Abdomen. [130.]
- Rumbling of the bowels, with colic (twelve hours and three-quarters after first dose, seventh day), 2.
- Excessive flatulent rumblings on awaking, for several mornings (seventeenth day), 3.
- Flatulence all day (seventh and twelfth days), 2.
- Excessive flatulence (nineteenth morning); and on waking (twenty-second morning), 3.
- Griping in the bowels (soon), (seventh day), 2.
- Tenderness in the abdomen at 8 A.M. (eighth day), 2.
- Severe colic pains, followed by a profuse and forcible diarrhœic alvine evacuation (one hour after first dose, fourth day), 2.
- Iliac Region.
- Aching in left inguinal canal, in the evening (twenty-fifth day), 3.
- Aching in inguinal canals, with acute pains in testicles, in the evening (twenty-sixth day), 3.
- Aching down right inguinal canal while sitting, in the evening (sixteenth day), 3. [140.]
- The pains in left testicle cause an aching along left inguinal canal, and extend to right testicle; at times they are so severe as almost to force me to call out, at noon (twenty-sixth day), 3.
- Aching returned in both inguinal canals; increased by walking; relieved by upward pressure on external rings; on rising (thirteenth day), 3.
- Continuous aching along the inguinal canals, most marked on right side, obliging me to walk continuously (after three hours, thirteenth day), 3.
- Slight aching down right inguinal canal, on awaking (fifteenth morning), 3.
- Awoke during night with pressive aching down left inguinal canal, relieved by upward pressure on external ring, lasting several minutes (seventeenth night), 3.
- Strong bearing down in left inguinal canal, as if hernia would protrude, while sitting, with acute pain on walking; relieved by upward pressure on external ring; lasting about fifteen minutes (after two hours); same in right inguinal canal, returning when pressure is removed; lasting fully two hours, in the evening; with severe loin pain, most marked to right of spine, lasting till retiring (twelfth day), .
RECTUM AND ANUS
- Bleeding from hæmorrhoids, which came on from constipation (thirteenth and fourteenth days), 3b.
STOOL
- Diarrhœa.
- Diarrhœic symptoms (four hours after first dose, third day), 2.
- Increased action of the bowels, aggravated diarrhœic symptoms; could have had a passage any time of day, but had perfect control of the sphincter ani (third day), 2.
- Bowels acted twice, motions loose, light in color (eighth day), 3.
- Bowels have acted twice to-day; motions slimy, of the peculiar dark shining brown; gushing out (sixteenth day), 3.
- Bowels acted twice; second motion half solid, with straining, half slimy, gushing out (eighteenth day), 3.
- Bowels acted twice; motion more natural (twenty-fifth day), 3.
- Bowels acted twice, first part of each motion being solid and natural, second part slimy, of a peculiar shining brown, but much less offensive (thirty-first day), 3.
- Bowels acted this morning only, motion shiny, of a peculiar grayish-brown, as if mixed with ashes (fourteenth day), 3. [160.]
- Motion to-day dark shining brown; strong odor (fifteenth day), 3.
- Motion to-day slimy, of a peculiarly shining dark-brown color (ninth day), 3.
- Motion to-day slimy, of a peculiar shining dark-brown, offensive, gushing out (twentieth day), 3.
- Motion slimy, of a shining yellow color, offensive (twenty-first day), 3.
- Motion partly solid, natural, partly slimy, dark-brown, offensive (twenty-second day), 3.
- Motions of the past two days have been of a peculiar shining brown, offensive (twenty-seventh day), 3.
- During the past few days the fæces have been partly solid and natural, partly soft, and of the peculiar shining brown; the first part being passed with much straining, the second part quite freely (thirty-sixth day); fæces gradually assuming their natural character (forty-first day), 3.
- On one occasion the fæces emitted a decided odor of the drug, 3.
- Constipation.
- Since commencing proving, bowels have acted regularly twice a day; motions papescent or watery till to-day, now decidedly constipated (seventh day), 3.
- Constipation; fæces hard, scanty, dark, passed with straining (eleventh, twelfth, thirteenth, and fourteenth days); softer and freer motions, of the peculiar shining color noticed in previous proving (eighteenth day), . [170.]
URINARY ORGANS
- Bladder.
- Tenderness in the bladder, at 8 A.M. (fourth day), 2.
- Urine.
- Specific gravity of urine 1020 (second day); 32 ounces of urine during the day (third day); sp. gr. 1020 (fourth day), 2.
- Urine clear, bright (even after standing all night), acid; sp. gr. 1012; free from albumen (before proving); clear, acid; sp. gr. 1016; free from albumen (after third dose, second day). For the first time exhibits a cloudy deposit, acid; sp. gr. 1021; free from albumen (after second dose, fifth day). Exhibits cloudy deposits, acid; sp. gr. 1016; free from albumen, phosphates, lithates, and sugar; microscopic examination shows mucus, epithelial cells, and very minute crystals (seventh day). Shows deposit of mucus, even while cooling; acid; sp. gr. 1012 (eighth day). Shows deposit of mucus while cooling; acid; sp. gr. on passing 1010, after standing 1014 (ninth day). Shows deposit of mucus; acid; sp. gr., fresh, 1012, on cooling, 1016; free from albumen (tenth night). Less clouded; acid; sp. gr., fresh, 1012, on cooling, 1018 (eleventh day). Less clouded; acid; sp. gr., fresh, 1008, on cooling, 1012; free from albumen (twelfth day). Less clouded; acid; sp. gr., fresh, 1014, on cooling, 1017 (thirteenth day). Slightly clouded; acid; sp. gr., fresh, 1007, on cooling, 1010 (fourteenth day). Scarcely clouded; acid; sp. gr., fresh, 1008, after cooling 1012; in the evening (fifteenth day). Shows deposits of mucus; acid; sp. gr., fresh 1014, on cooling, 1018; free from albumen; in the evening (sixteenth day). Shows but a trace of mucus; acid; sp. gr. 1010 fresh; 1014 on cooling (seventeenth day). Scarcely clouded; acid; sp. gr. fresh, 1015, on cooling, 1019 (eighteenth day). Slightly clouded; acid; sp. gr., fresh, 1004, on cooling, 1006; free from albumen, phosphates, lithates, and sugar; microscopic examination showed scattered mucus and epithelial cells, abundance of spermatozoa, and oxalate of lime crystals (twentieth day). Slightly turbid, free from deposit; acid; sp. gr., fresh and on cooling, 1010 (twenty-second day). Clear: acid; sp. gr. 1018; free from albumen (twenty-seventh day). Clear; acid; sp. gr. 1010 (thirty-second day). Clear; acid; sp. gr. 1014 (forty-first day), 3.
- Urine acid, free from albumen, shows slight deposit of mucus; sp. gr., 1012 (before the proving); light deposit of mucus; acid; sp. gr. 1015 (third day), 3a.
SEXUAL ORGANS
- Neuralgic pain in left testicle and in right supraorbital region (thirty-second day), 3.
- Aching in left testicle, while sitting, at 1 P.M. (twenty-ninth day), 3.
- Acute aching in left testicle, with occasional darting pains, changing to right, then again to left, after rising (twenty-sixth day), 3.
- Acute pains in testicles, first left, then right, then in both; recurring and lasting the whole evening, with aching in inguinal canals (twenty-sixth day), 3.
- Sharp darting pains through left testicle (epididymis), several times repeated, at 10 P.M.; passing to right testicle; leaving dull achings; recurring till midnight (twenty-fifth day), 3.
RESPIRATORY ORGANS
- Larynx. [180.]
- Constriction of larynx, in the evening (sixteenth day), 3.
- Constriction of larynx, with return of giddiness, while sitting, at 7 P.M. (twenty-third day), 3.
- Constriction to left of larynx, at 7 P.M. (twenty-third day), 3.
- Respiration.
- Increased bronchial irritation; increased cough; unpleasant and sweetish expectoration, at times difficult (ninth day), 3b.
- Cough deep and violent (eleventh day), 3b.
- Cough in evening, also during night, without waking, with slight pale expectoration (fourth day), 3b.
- Cough and expectoration immediately renewed on change to colder weather, and by cold winds (eighteenth day), 3b.
- Sighing respiration, at 7 P.M. (twenty-third day), 3.
- Sighing and yawning (twelve hours after first dose, fifth day), 3.
- Wheezing, during evening (fourth day), 3b. [190.]
- Accelerated respiration during exercise, much more marked while ascending stairs, in the early part of the day (fifth day), 2.
- Respiration 17, in the evening (fifteenth day), 3.
- Respiration 19 (half an hour after second dose, fifth day); at 10 P.M. (seventh day); in evening (ninth day), 3.
- Respiration 20 (twenty-ninth day); at 10.30 P.M. (forty-first day), 3.
- Respiration 23 (thirty-second day), 3.
- Oppression of respiration, in the evening (sixteenth day), 3.
- Oppressed respiration, with sighing (after half an hour, tenth day), 3b.
- Respiration oppressed at 7.30 P.M., lasting till 9 P.M. (thirty-sixth day), 3.
- Dyspnœa, as from bronchial cold, increased during evening (fourth day), 3b.
CHEST
- Spasms of right intercostals, on awaking (fifteenth morning), 3. [200.]
- Spasms in right intercostals, while lying on right side before rising (twenty-sixth morning), 3.
- Occasional pains in chest (fourth day), 3b.
- Severe pain in right side of thorax at insertion of pectoral muscles, becoming acute on inspiring deeply, before retiring (twenty-ninth night); returning in the morning on awaking; passing during the day to apex of heart, of heart to right axilla, down pectoral muscles to former spot, again to apex of heart, and passing off from right side of thorax (thirtieth day), 3.
- Intercostal pains, worse when lying on right side, extending to apex of heart, in the morning before rising (eighteenth and twenty-third days), 3.
- Severe intercostal pains, both right and left, with repeated acute darting pains at apex of heart, increased by lying on right side, on waking (nineteenth morning), 3.
- Sense of constriction across lower half of thorax, impeding respiration, with subacute pain, increased by lying on right side, on waking (seventeenth morning), 3.
- Subacute pain in fifth right interspace, quickly abating (tenth day), 3.
- Subacute pain at fourth left interspace (twelfth day), 3.
- Subacute superficial pain at third left interspace near sternum, becoming acute on moving, lasting fully ten minutes, passing to mid-sternum (after three hours, thirteenth day), 3.
- Subacute pain in intercostal muscles below fifth rib on each side, increased by lying on right side, on waking (twenty-first morning), 3. [210.]
- Acute pain in intercostal muscles over base of heart, lasting several minutes, at 1.45 P.M. (twenty-sixth day), 3.
- Acute superficial pain at third and fourth left interspaces (after one hour, fifteenth day), 3.
- Pleurodynia below fifth right costal cartilage, passing to left, then again returning to right side, on awaking (sixteenth morning), 3.
- Pleurodynia from third to seventh left interspace; with acute pain at apex of heart, with contraction of intercostal muscles, increased by lying on right side, on waking at 6.30, lasting till 10 A.M. (eleventh day), 3.
- Subacute pain an inch below and to outer side of left nipple, quickly subsiding, succeeded the oppressed feeling in brain (after second dose, second day), 3.
HEART AND PULSE
- Præcordium.
- The cardiac pains were of a rheumatic character, 3.
- Constrictive pain and tenderness around the heart (six hours after first dose, third day), 2.
- An hour after rising, rheumatoid aching over the apex of the heart, then above right nipple, then returning to left side, from third to sixth left interspaces inclusive, with subacute pain in apex itself; during day aching pains from third to sixth left interspaces; at apex and above right nipple; occasionally acute, worse towards sunset (second day); during day, subacute pains over apex of heart and above right nipple, with dull temporal headache (third day), 3a.
- Rheumatoid aching in region of apex of heart, followed by erratic rheumatoid pains, chiefly in left wrist, inner side of right calf, right subclavicular region, and again in left wrist and region of apex of heart (after two hours), 3c.
- Acute darting pains in heart, with complete intermissions, lasting fully an hour (fourteenth day), 3b. [220.]
- A very marked sensation in the cardiac region, of a constrictive character, lasting three hours, in the early part of the day (fifth day); subacute pain at apex of heart, of short duration (after two hours and a quarter, seventh day); cardiac distress, scarcely amounting to pain, most marked at apex, after rising (ninth morning); subacute pain at apex (of heart), extending to third left interspace (after fifteen minutes, tenth day); slight pain at apex (of heart), (after two hours, tenth day); subacute pain at apex of heart, during the day (twelfth day); repeated sharp superficial and deep pains in præcordial region, during the afternoon (fifteenth day); cardiac pains, in the evening (fifteenth day); subacute pain in præcordial region and left frontal eminence, at 1 P.M. (sixteenth day); acute darting pains at apex of heart, at 6 P.M. (sixteenth day); darting pain at apex of heart, in the evening (sixteenth day); subacute pain over cardiac region, with cardiac distress, at 5 P.M. (twenty-third day); return of acute pain at apex of heart, at 7 P.M. (twenty-third day); the cardiac distress and palpitation were increased by ascending (stairs or hill), by excitement, by deep inspiration, and by thinking of them, 3.
- A very sensible pressure in the cardiac region; the cardiac viscera pressing outwards, but not painful, at 7.30 P.M. (thirteenth day), 2.
- Heart's Action.
- On lying down, palpitation, with altered rhythm, the systole being shortened and the interval lengthened (first day), 3a.
- Cardiac depression (tenth day), ; with intermittent pulse, in evening (fourth day), .
NECK AND BACK
- Neck.
- Pains in nape of neck, passing off quickly, not relieved by friction (eleventh day), 3.
- Congestive pain in nape of neck, with severe continuous lumbar and dorsal pain, worse towards left side, in the evening (eleventh day), 3.
- Heavy aching in cervical region (after one hour, seventeenth day), 3.
- Sharp aching in nape of neck, left side, soon transferred to right frontal eminence (after five minutes, fifteenth day), 3.
- Steady subacute pain in cervical muscles, more to left side (one hour and a half after second dose, sixth day), 3.
- Acute pain in nape of neck (cervical muscles), following rheumatoid pain in limbs (ten minutes after second dose, sixth day), 3. [240.]
- Acute pain at seventh cervical vertebra (after tow hours and a quarter, seventh day), 3.
- Back.
- Severe aching down spine, somewhat relieved by friction, passing off after rising (nineteenth morning), 3.
- Severe continuous lumbar and dorsal pain, worse towards left side, with congestive pain in nape of neck, in the evening (eleventh day), 3.
- Pain from left molars went to lumbar region, then went rolling up the spine like a ball, and settled in mid-dorsal region, chiefly to left of spine; afterwards returned to left lower molars, in the evening (eighteenth day), 3.
- Dorsal.
- Slight rheumatoid pain in left suprascapular muscles (after tow hours and three-quarters, seventh day), 3.
- Aching across lower dorsal region, at noon (twenty-sixth day), 3.
- Hot sensation, first under right scapula, then in centre of left lung, and again beneath right scapula, possibly caused by easterly wind (fourth evening), 3a.
- Slight aching in lower dorsal and lumbar region, at 5 P.M. (twenty-third day), 3.
- Slight aching to left of lower dorsal region, before retiring (twentieth night), 3.
- Slight achings in lower dorsal region, in the afternoon (twenty-ninth day), 3. [250.]
- Hot achings beneath right scapula, during evening (fourth and ninth days), 3b.
- Before rising free from pain; immediately after, rheumatoid aching in right scapular muscles, still continuing at 10.50 A.M. (eighth morning), .
EXTREMITIES IN GENERAL
- Pains in limbs, during afternoon (ninth day), 3.
- Pains in left wrist, left leg, and right leg, passing off quickly, not relieved by friction (eleventh day), 3.
- Rheumatoid pains, especially left leg and forearm (after two hours, tenth day), 3.
- Aching in left hand and right knee, while sitting, at 1 P.M. (twenty-ninth day), 3.
SUPERIOR EXTREMITIES
- Acute pain in left axilla, extending down edges of pectoral muscles to thorax; then passing to base of heart, then to apex at 7 P.M. (twenty-third day), 3.
- Slight aching down left forearm, on awaking (ninth morning), 3.
- Slight achings in left wrist, right knee, left tibia anteriorly, left knee and right forearm, in the afternoon (twenty-ninth day), 3.
- Darting pain through right wrist, at 10.45 P.M. (sixteenth day), 3. [280.]
- Unsteadiness of hands, rendering writing somewhat difficult (twelve hours after first dose, fifth day), 3.
- Trembling of hands, at 1 P.M. (sixteenth day); at 7 P.M. (twenty-third day), 3.
- Trembling weakness of hands (after twenty minutes, ninth day), 3.
- Return of tremulous feeling in hands, while writing, lasting several minutes (sixth day), 3.
INFERIOR EXTREMITIES
- Slight lameness, in the evening (fifteenth day), 3.
- Feeling of unsteadiness in walking (thirteen hours after first dose, fifth day), 3.
- The left limb feels full one-half inch shorter than the other, and the foot sounds on the sidewalk as if this positively was the case (after five hours, second day), 2.
- Thigh.
- Aching down both thighs on rising, with weakness in walking (sixteenth morning), 3.
- Aching down flexor muscles of right thigh, extending to knee and calf of leg, then to left knee and calf, then returning to right thigh and knee, with slight lameness (after four hours, fifteenth day), 3.
- Steady aching in right thigh and knee-joints, with acute pains in usual spots, during the afternoon (fifteenth day), 3. [290.]
- Acute pain down anterior muscles of right thigh causing lameness, at 5 P.M., afterwards in both (twenty-sixth day), 3.
- Knee.
- Pain from front of right knee transferred to back of left, at 10.20 P.M. (sixteenth day), 3.
- A huskiness in the left patella, dull pain in the knee, continuing through the day, but more intense while in motion (fifth day), 2.
- Slight huskiness of the left patella on motion (after one hour, fourth day), 2.
- Leg.
- Occasional pains in legs, especially left, in the evening (ninth day), 3.
- Sharp aching in right leg, not relieved by friction, during the afternoon (tenth day), 3.
- Sharp aching down right tibia, causing lameness, not relieved by friction, during the morning (fourteenth day), 3.
- Rheumatoid pain, commencing in left calf and finishing in right, during the day (eighth day), 3.
- Rheumatoid pain in calves of legs, especially left, succeeded by acute rheumatoid loin pain, extending to lower dorsal region (after two hours and a quarter, seventh day), 3.
- Slight aching in left calf, quickly transferred to right, on waking (ninth morning), 3. [300.]
- Acute pain in inner muscles of left calf, with straining and lameness (after a few minutes, fifteenth day), 3.
- Subacute pain down muscles of left calf, at 7 P.M. (twenty-third day), .
GENERAL SYMPTOMS
- Objective.
- Increased mental and physical activity, in the evening (twenty-sixth day), 3.
- Increased mental and physical activity, on the passing off of the headache (twenty-first day), 3.
- General depression (twenty-seventh day), 3.
- Vital depression (after one hour, seventeenth day), 3.
- Depression of vital power, in the afternoon (seventh day), 3.
- General debility, at 10 A.M. (tenth day), 3.
- Great debility, especially on walking, in the evening; I have taken extra stimulant to keep me going (fifteenth day), 3.
- Faintness, with slight nausea, when walking in the open air, at 7 P.M. (twenty-third day), 3. [310.]
- Faintness, with cardiac depression, in the evening (twenty-fifth day), 3.
- Restless activity; ready for any amount of work, in the evening (twelfth day), 3.
- Restless activity not with standing nausea, giddiness, and pains, all of which have been very severe, in the evening (sixteenth day), 3.
- Subjective.
- General feeling of weakness and weariness (after two hours and three-quarters, seventh day), 3.
- Sensations of faintness, with unsteadiness in walking, at 1 P.M. (sixteenth day), 3.
- General malaise (eighth, eleventh, and fourteenth days); during afternoon (ninth day), 3 ; (tenth day), 3b.
- Pains at apex of heart, in left wrist, left leg, right leg, nape of neck, and loins, passing off quickly, not relieved by friction (eleventh day), 3.
- Shifting pains (after three hours and a half, fifteenth day), 3.
- Shifting pains, most persistent in right knee, in the evening (sixteenth day), 3.
- Flying pains (eighth day), 3. [320.]
- Flying pains in various parts (after six hours, seventh day), 3.
- Acute flying pains to right of middle dorsal region, in nape of neck, frontal eminences, left wrist, left lower molars (sound teeth), lumbar region, and again in nape of neck (soon, fifteenth day), 3.
- Flying muscular pains, with persistent aching in loins and occiput, increased by movement; not lessening, as formerly, after a meal (after four hour and a half, seventh day), .
SKIN
- Prickings (urticaria?) as if bitten by an insect, in left forearm, hypogastrium, right leg, right forearm, back, and again in left forearm, in the afternoon (seventeenth day), 3.
- Severe irritation, like urticaria, on various parts, during afternoon (nineteenth day), 3.
- Troublesome urticaria, especially affecting left forearm and right leg, before retiring (nineteenth night), 3.
- Troublesome irritation (urticaria), especially of left forearm and right leg, during the day; more troublesome and extending to right forearm, in evening (twentieth day), 3 . [I cannot say this irritation is a drug-effect, as I have had slight urticaria on previous occasions, but its development follows the rule of preceding symptoms.]
- Irritation has returned in left forearm, right leg, to left of lower dorsal vertebræ, right forearm, and left leg, in the evening (twenty-first day), 3.
- Urticaria, during the day (twenty-second day), 3.
SLEEP AND DREAMS
- Did not sleep as soundly as usual (eighth night), 3.
- Night very restless, full of troubled dreams (first night), 2. [350.]
- Wakefulness on retiring, though fatigued (second night), 3b.
- Unusually early waking (third morning), 3b.
- Retired last night at 11; slept well till daylight, then awoke (quite unusual), and had light dreamy sleep after (eighth morning), 3.
- Awoke at daylight and slept but indifferently afterwards (thirteenth morning), 3.
- Awoke at 5, light dreamy sleep after (seventeenth morning), 3.
- Awoke at 5, after dreamy, though not restless sleep; slept indifferently till 8; then awoke free from pain (tenth morning), 3.
- Sleep dreamy (first night), 3b ; (twenty-first night), 3 ; not restless (first day), 3a.
- Sleep dreamy and disturbed (not restless), (fifth night), 3.
FEVER
- Temperature 36.40° C. (before proving); 36.30° C. (after third dose, second day); 35.90° C. (half an hour after second dose fifth day); 36.20° C., at 10 P.M. (seventh day); 36.30° C., in the evening (ninth day); 36.40° C. (tenth night); 36.10° C. (fourteenth day); 36.10° C., in the evening (fifteenth day): 36.70° C., in the evening (eighteenth day); 36.95° C. (twenty-ninth day); 36.40° C., at 10.30 P.M. (forty-first day), 3. [360.]
- Feverish feelings (from cold), in the evening (eighteenth day), 3.
- Agreeable sensation of warmth, first to left of epigastrium, then in region of apex of heart, then at base of heart (third day), 3b.
- Faint perspiration on covered parts when walking, in the afternoon (fifteenth day), 3.