Veratrum viride, Ait.

Natural order , Liliaceæ.

Common names , American white hellebore, Indian poke, etc.

Preparation , Tincture of the root.

Authorities.

1 , "W.," Bost. Med. and Surg. Journ., vol. x, 1834, p. 216, took 2 grains of extract of root, then 4 grains (first day); two doses of 3 grains each (second day); 1 a , same, took 1/4 grain every three hours for three days; 2 , Charles Osgood, M.D., Amer. Journ. Med. Sci., vol. xvi, 1835, p. 302, took 2 grains finely pulverized extract at 12 M.; 3 , same, a man took 2 grains, afterwards 4 grains; 3 a , same, feeling well the next day, took 3 grains at 7 A.M., 12 M., and 2 grains at 11 P.M.; 3 b , took three or four doses of 1/2 grain each, at intervals of three hours; 3 c , 1/4-grain doses continued for three days, at intervals of three hours; 3 d , 1/3-grain doses at same intervals, for three or four days; 4 , S. A. Hubbard, Bost. Med. and Surg. Journ., vol. xix, 1838, p. 31, five persons ate Verat. vir., cooked with other vegetables; 5 , Cutter, Rickard, and Ingalls, Amer. Journ. Med. Sci., 1861 (2), p. 398, Dr. James Robbins made a trial; 6 , Ephraim Cutter, Med. Times and Gaz. (Mon. Hom. Rev., 1862, p. 494), put 60 minims into syrup gum acaciæ and water, 1/2 ounce each, took one-seventh at 6.30 P.M., other doses at 7.30 and 10.30 P.M.; 7 , Dr. B. Woodward, Med. and Surg. Rep., Phila., Nov. 1860, p. 109 (ibid.), took 8 drops Norwod's tincture at 8 P.M., 4 drops at 10 P.M., and 3 drops at 12 M.; 8 , S. W. Abbott, M.D., Bost. Med. and Surg. Journ., 1862 (1), p. 186, four doses of 10 drops of tincture of seeds; 8 a , same, took 20 drops once an hour; 8 b , same, took 7 drops tincture of plant at 2 and 4 P.M., 4 drops at 6 P.M., 6 drops at 8 P.M.; 9 , Lancet, 1862 (1), p. 54, a tincture was given for toothache, and a portion accidentally swallowed; 10 , G. J. Scatter-good Proc. Amer. Pharm. Assoc., 1862 (Amer. Journ. of Pharm., 1863, p. 77), took 2 grains alcoholic resin at 5.15 P.M.; 11 , G. N. Edwards, Med. Times and Gaz., 1863 (1), p. 5, a man took 1 drachm tincture; 12 , W. H. Burt, M.D., Hale's New Remedies, p. 1033, in perfect health, took 30 drops of 3 dec. dil. of fluid extract prepared in water at 9.50 A.M., 50 drops at 11 A.M., 60 drops at noon, 100 drops at 2 P.M., 150 drops at 3 P.M., 200 drops at 5 P.M., 175 drops at 7 P.M. (first day); 3 drops fluid extract at 9 A.M., 4 drops at 10 A.M. 5 drops at 12 M., 6 drops at 2 and 4 P.M., 8 drops at 9 P.M. (second day); 10 drops at 9 A.M., 12 drops at 10 A.M. and 12 M., 8 drops at night on retiring (third day); 10 drops at 8 and 10 A.M., and 12 M. (fourth day); 13 , same, a girl, aged twenty-one months, took a few drops of tincture; 14 , Hale, ibid,. a young girl took 20 drops; 15 , Jones and Scudder's Mat. Med. (ibid.), took 1/4 grain alcoholic extract; 16 , same, 1/2 fluid drachm tincture instead of Gelseminum; 17 , James Watson, M.D., Edinb. Med. Journ., 1864, p. 616, took 8 drops tincture at 3, 5, and 7 P.M.; 18 , Samuel R. Percy, M.D., An Inquiry into the Phys. and Med. Properties of Verat. vir., Phila; 1864, p. 75, in 1823 a farmer boiled 10 pounds of swamp Hellebore in water down to a gallon of fluid, of which his wife took a tumblerful; 19 , same, in 1840 a person prepared 2 quarts of syrup from 2 pounds of Verat. vir., and took a tumblerful twice; 20 , N. O. Pearson, M.D., Chicago Med. Examiner (ibid.), a patient took 20 minims in an hour and a half, in three doses; 21 , Dr. Buckingham, Med. Invest., Dec. 1865, p. 32, H. C., took a swallow of extract; 22 , another man took the same; 23 , J. C. Harris, M.D., Bost. Med. and Surg. Journ., 1865 (1), p. 249, a boy, aged eighteen months, took four or five doses of the tincture, probably not less than 35 drops, death in thirteen hours; 24 , Dr. W. H. Woodbury, Med. Invest., Dec. 1865, p. 27, a man aged forty-five years, as an expectorant, took 20 drops tincture in two doses; 25 , Mr. P.M. Rice, Brit. Journ. of Hom., vol. xxiv, 1866, p. 343, took 20 minims of tincture in 1 ounce of water; 26 , Charles Bullock, Proc. Amer. Pharm. Assoc., 1867 (Am. Pharm. Journ., 1868, p. 64), took 1/3 grain resin dissolved in alcohol, every half hour, until 2 grains were taken; 27 , Dr. Hadlock, Med. and Surg. Rep., No. 8, 1870 (Practitioner, vol. iv, 1870, p. 375), effects of large doses; 28 , E. M. Hale, Amer. Obs., vol. vii, 1870; 29 , H. C. Wood, M.D., Amer. Journ. Med. Sci., 1870 (1), p. 51, took 1 grain alcoholic resin at 3.35 and 4.15 P.M., 2 grains at 5.20 P.M.; 30 , same, took 1/18 grain Viridiæ sulph. in aqueous solution at 11.40 A.M., 12 M., 12.35 and 1.40 P.M., 1/9 grain at 2. 10 and 3.15 P.M., 1/6 grain at 4 and 4.30 P.M. ( 31 to 33 , E. W. Berridge, North Am. Journ. of Hom., New Series, 2, May, 1872, p. 505); 31 , James Lillie, M.D., dissolved 1 drop of tincture in 1 1/2 pints of water, shook it and took a wineglass at 8.5 P.M., another wineglassful before 9 P.M., another at 10.30. P.M. (first day); same at 8 A.M., 2 glasses at 9.30 A.M., 1 glass at 5 P.M., after dinner (6.45) 3 glasses, at 8.45 P.M. 3 glasses of a dilution made of one wineglassful of the former to 1 1/2 pints of water (second day); 4 wineglasses at 8.15 A.M., 4 glasses of a 3d dil. made as before, at 11 P.M. (third day); 4 glasses at 7 A.M., 5 glasses at 9.30 A.M. (fourth day); 2 glasses before 5 A.M. (fifth day); 4 glasses of a 4th dil. made as before, at 11 A.M. (sixth day); 1 drop of 1st dil. at 11.15 A.M., 3 drops at 10.48 P.M. (twelfth day); 10 or 12 drops of 1st dil. in 2 ounces of water at 8.30 A.M., 6 drops of 1st dil. at 10.57 P.M. (fourteenth day); 12 drops of 1st dil. in 1 1/2 ounces of water, and gradually sipped it in two or three minutes, at 11 P.M. (fifteenth day); 2 or 3 drops of 1st dil. at noon, in evening made 30th dil. from 3d, drank all the intermediate watery dilutions at once (sixteenth day); 1 drop of tincture in a glass of water, at 10, 35 P.M. (twenty-third day); 1 drop of tincture in a wineglass of water at 12.30 P.M., 1 drop of tincture at 4.15 and 10.20 P.M. (twenty-fourth day); 1 drop of tincture at 8.45 A.M., 1 drop at 10.45 P.M. (twenty-fifth day); 3 drops of 3d in sugar, at 1.30 P.M., repeated dose at 7 P.M., 1 drop in water at 10.10 P.M. (thirtieth day); 1 drop of 3d at 8.15 A.M., 1 drop of 3d on sugar at noon, 3 drops at 6 P.M., 5 or 6 drops at 10.30 P.M. (thirty-first day); 7 or 8 drops at 8.30 A.M., 3 drops of 3d in water at 1 P.M., 7 drops of 3d in water at 10.20 P.M. (thirty-second day); 3 or 4 drops of 30th dil. at 8 A.M., same dose twice in afternoon, 6 or 7 drops of 30th at 10.40 P.M. (thirty-seventh day); 2 drops of 30th at 11 A.M. and 8 P.M., 2 or 3 drops at 10.10 P.M., and 2 drops at 10.20 P.M. (thirty-eighth day); 40 or 50 globules of 200th (forty-third day); 10 globules of 200th dil. at 11 A.M., 20 or 30 globules of 200th at 10.45 P.M., then 17 globules (forty-fourth day); 10 globules at 8.40 and 11.20 A.M., 12.20, 2.30, 4.30, and 6.20 P.M. (forty-fifth day); 3 globules of 30th at 10.5 A.M., afterwards a wineglass containing all the dilutions between 30th and 200th, then another, and a third wineglass at 10.30 P.M. (forty-sixth day); 32 , Dr. Berridge, took 10 globules of Dr. Lillie's 200th; 33 , Mr. ---, took 201st prepared from Dr. Lillie's 200th, 12 drops in half a tumbler of water, and a dose at 12.50 and 3.30 P.M. (first day); a dose at 10.40. and 4 P.M. (second day); 2 drops at 10 A.M. (fifth day); 34 , J. P. Truman, M.D., Hahn. Monthly, vol. viii, 1872, p. 46, a man aged about fifty-five years, who had sciatica, with scarcely any concomitant symptoms, took Verat., macerated in whiskey, for two days, in sufficient quantities to produce perspiration, then took 1/2 ounce of the whiskey tincture at one dose; 35 , Berridge, North. Amer. Journ. of Hom., New Series, vol. iii. 1873, p. 500, Mrs. ---, dissolved 1 drop tincture in 1 1/2 pints water, and took a wineglassful at 8.5 P.M.; 36 , Dr. N. Ford, Med. Rec., vol., ix, 1774, p. 155, effect of overdose; 37 , J. Steele Bailey, M.D., New Orleans Med. and Surg. Jour., July, 1877, p. 38, case of poisoning; ( 38 to 42 a , R. B. Sullivan, M.D., copied from MS.); 38 , T. L., aged fourteen years, took 10 pellets 3d dec., every half hour, all day, for four days, a solution of 5 drops tincture in water every half hour (sixth day); 39 , E. B. S., took 10 drops tincture in afternoon (first day), 5 drops every half hour (second day); 39 a , same, two days later took 5 drops 1st dec. every half hour all day (first day), 1st dec. all day (second and third days), 3d dec. every half hour (fourth day); 40 , W. E. D., took 10 drops 6th dec. at 9.20 and 10.20 A.M. and 1 P.M. (first day); 10 drops 1st dec. at 10.12 A.M. and 1 P.M. (second day); 40 a , same, took 3 drops tincture at 7 and 10 A.M., and at 2, 6, 6.30, and 10 P.M. (first day), same at 7.45 and 11 A.M. (second day), 10 drops at 8 A.M., 12 M., and 7 P.M. (fourth day); 40 b , same, took pellets saturated with 30th potency, every half hour, for six days, with no results, then took pellets saturated with 3d potency, every half hour (first and second days), began at 2 P.M. (fourth day); 40 c , same, took 3d potency every half hour (first day), 5 drops tincture every hour (third day), 10 drops tincture at 8 and 9 A.M., 12 M., and at 1 and 2 P.M. (fourth day); 41 , J. H. C., aged twenty-eight years, began at 7 A.M. to take 10th potency, every twenty minutes (first day), continued (second day); 42 , B. G., aged forty-six years, had rheumatic pains in the back, hip, and side, superficial vein of scrotum varicosed, pains along the spermatic cord, dull heavy pain in frontal region, with vomiting, took drop doses of tincture every half hour for four days; 42 a , the same, three days later took 5 drops 1st dec. every fifteen minutes.

MIND

Temporary delirium, 4.*
*Quarrelsome and delirious, striking and kicking with right hand and foot ; at times these movements appeared to be involuntary; this mental condition changed to a happy and comical delirious state, which continued fifteen hours, 34.
Although I thought it probable I should die, I did not feel alarmed, 25.
(Some depression of spirits (fourth day); great depression (fifth day)), 42.
Depression and prostration, 17.
Great fear of death, 34.
Most of the time, between the vomiting spells, he was lethargic, with slow and difficult respiration, 32.
When not vomiting she lay in a stupor, 13.
(Feels stupefied, with great pain and fulness in head), (first and second days), 42a. [10.]
Apparently unconscious (after seven hours), 23.

HEAD

Confusion and Vertigo.
Confused sensation in head (after two hours), 3a.
Vertigo, 1, 2, 3 , etc.*
When rising from a seat, or from bed, a slight dizziness (fourth day), 38.
Vertigo with the nausea (second day), 41.*
Dizziness and nausea, followed by heat of surface (fourth day), 40c.
Dizziness on rising, in the morning (seventh day), 38.
Vertigo and sudden prostration, 34.
(Must keep is bed; vertigo and vomiting as soon as he rises ), (fifth day), 42.
Vertigo and photophobia; relieved by closing eyes and resting head, in the morning (third day), 38. [20.]
Dizziness and pain in the head (after ten or fifteen minutes), 24.
General Head.
Dull feeling in the head all the afternoon and evening (fourth day), 40c.
Heavy dull pain in head with the weakness (first day), 41.
Head felt full and heavy (second morning), 41.*
Heavy dull headache, with occasional painful throbbing in the temples (after four hours), 17.
Constant dull headache at 4 P.M. (second day), 12.
(Violent headache of a central congestive character); aggravated by noise and motion (fifth day), 42.
(Violent headache, with severe vomiting every fifteen or twenty minutes), (first and second days), 42a.
During this proving had no headache after the first and second days, 40a.
Headache, which stopped at the temples and seemed to take a diagonal course across the head (after two hours, fourth day), 40b. [30.]
Slight headache, with full, pressing, heavy feeling in eyes (first day), 41.
Queer feeling about the head (after two hours, second day), 1.
(Burning sensation of head, with flushed face), (fifth day), .

EYE

Full, pressing, heavy feeling in eyes, with slight headache (first day), 41.
Aching in left eye, while riding in omnibus (after-second dose, second day), 31.
Severe shooting suddenly-stopping pain in left eye (a few minutes after second dose, fourth day), 31.
Brow and Orbit.
On going to bed, had an intense, painful itching in middle of left eyebrow (twenty-fourth day), 31.
A dull heavy feeling over left eye, worse when stooping, at 2 P.M. (second day), 40.
A distinct ache, directly over right eye (immediately, after first dose, fourth day), 31.
Aching in upper part of right orbit (twelfth and sixteenth nights), 31.
Slight transient pains above the right eye (after half an hour, twenty-third day), 31.
Pain in upper half of right orbit (after first dose, thirty-eighth day), 31.
Lids. [60.]
Feeling of fulness about the eyelids, as if he had been crying a good deal, with increased secretion of tears (ten minutes after third dose, first day), 38.
Eyelids heavy and sleepy, with soreness (fifth day), 33.
Lachrymal Apparatus.
(Increased tears), (fifth day), 42.
Profuse secretion of tears at 2 P.M. (third day); at 1 P.M. (fourth day), 12.
Pupil.
*Dilated pupils, 2, 12, 14 , etc.
Vision.
Dimness of sight, 2, 3, 24.*
(Dimness of vision; green circles around the gaslight), (fifth day), 42.
Cannot walk; if I attempt it I am very faint and completely blind ; obliged to keep in the horizontal position, at 2.20 P.M.; cannot walk across the room without becoming blind, at 4 P.M.; can walk about ten rods, when I become blind, and am compelled to sit down, at 5 P.M. (third day), .*

EAR

A fulness in the left ear, with a continued beating of the carotids, I could hear it beat distinctly, during the proving, 40b.
Fulness and throbbing in the carotid in the left ear; this came on soon after beginning to take the drug (fourth day), 40c.
Ringing in the ear; moving quickly makes me very deaf; at 2 P.M. (fourth day), 12.
(Hears noise in ear), (fifth day), 42.
(Humming in ears and sensitiveness to noise ; ears feel cold with spells of deafness), (fifth day), 42.

NOSE. [80.]

Nose looks pinched and blue at 2 P.M. (third day), 12.
For the third time noticed nasal catarrh and sneezing, soon passing off (shortly after third dose, thirty-second day), 31.
With the vomiting, running from the nose and eyes, 11.
Profuse secretion of mucus from the nose at 2 P.M. (third day); at 1 P.M. (fourth day). 12.

FACE

Features sunken, 11.
Face pale (second day), 39.
Face very pale at 2 P.M. (third day), 12 ; (after seven hours), 23.
Very pale, with cadaverous look (after half an hour), 24.
*(Face flushed) , (fifth day), 42.
Face blue, 13. [90.]
Blue hippocratic face for three hours, 13.
Stinging pain in right jugum malar (forty-fourth night), 31.
Distinct pain in right angle of lower jaw (after third dose, thirtieth day), 31.
Dry lips and mucus of mouth thick (third day); dry mouth and lips all day (fourth day); mouth less dry (fifth day), 33.*
Jaws rigid, and nothing could be put into her mouth, 13.

MOUTH

Teeth.
(Toothache cured), 9.
Tongue.
Tongue white, not coated; looked as if bleached (second day), 40a.
Tongue white in the centre, with red edges and white tip; it does not look like a coated tongue, but as if the blood were pressed out, in the morning (third day); edges red, tip white, and centre almost a pure white (fourth day), 38.
(Tongue coated yellow, especially along the base and centre), (fifth day), 42.
Tongue coated yellow along the centre, in the morning (third and fourth days), 12. [100.]
Tongue bright red at tip and edges, and white in centre (second day), 39.
Tongue red on the edges, grayish from the tip half way back; the back part gray, with red spots of the size of a pin's head. Strawberry tongue (fourth day), 40a.
(Tongue feels as if he had been drinking hot tea; scalded, coated yellow at base and edges; somewhat red in centre ), (fifth day), 42.*
(Tongue feels as if it had been scalded , coated yellow, with red streak in centre) , (first and second days), 42a.*
Tongue feeling as if it had been scalded, at 9 P.M. (second day); at 8 A.M. (fourth day), 12.
Acrid, burning sensation in the mouth, 15.
Saliva.
Great increase of secretion of saliva (first day), 10.
With the hiccough there was copious secretion of saliva and discharge of mucus from the stomach and nose, 15.
Profuse secretion of saliva at 2 P.M. (third day); at 1 P.M. (fourth day), 12.
Taste.
Flat taste in the mouth, in the morning (third day), 12. [110.]
Flat, bitter taste in the mouth, in the morning (fourth day), 12.
Taste bitterish, disagreeable, peculiar, reminding one of the odor of spermatic fluid, 30.
(Food tastes bitter), (fifth day), .

THROAT

Dryness of throat for one hour, causing short dry cough (one hour and a half after first dose, second day), 33.
In the throat and fauces a sense of dryness and heat, which finally reached the stomach; in the course of an hour this dryness and burning sensation in the throat and stomach became intense, and a disposition to hiccough was excited, which commenced, gradually increasing in frequency until it reached fifteen or twenty times in the minute; this was attended with some sickness and retching until vomiting took place; this was violent, and seemed to come on about every ten or fifteen minutes for the space of an hour, 15.
Burning in the throat, 14.
Burning sensation in throat, œsophagus, and stomach (after ten or fifteen minutes), 24. [120.]
Ever since swallowing the dose there has been a persistent, peculiar numbness in the fauces (after twenty minutes); after second dose the numbness of fauces was for awhile very marked; not so much so now (after thirty-five minutes); numbness still persistent (after one hour and a third); numbness of throat not noticeable (after three hours), 30.
With the hiccough, violent and constant spasms of the upper part of the œsophagus; cannot swallow, at 2 P.M. (third day); at 1 P.M., lasting two hours (fourth day), 12.
Sensation of something like a ball rising in the œsophagus, which seemed to extend up as far as the top of the sternum, as if propelled by a gradual tonic contraction of the stomach (after one hour), 3.
(Inclination to swallow, with burning pain along the œsophagus), (first and second days), 42a.
Submaxillary glands swollen, sore to touch (fourth day), 38.

STOMACH

Appetite and Thirst.
Ravenous appetite on waking, in the morning (second day); at noon (fourth day), 40a.
Very thirsty, drinks little, which relieves for a short time (third day), 38.
Thirst , with slight nausea, an hour after rising, in the morning (third day), 38.*
Eructations.
Frequent eructations of wind, 29.
For several days the patient was troubled with an acrid, sour rising from the stomach, 34.
Hiccough. [130.]
Almost constant hiccough, 3.*
It causes excessive and painful singultus, 8.*
Hiccough, with the frontal headache, at 2.20 P.M. (third day), 12.
Constant hiccough, with violent and constant spasms of the upper part of the œsophagus , at 2 P.M. (third day); at 1 P.M. (fourth day), 12.*
Hiccough, with constant and severe spasms of the upper part of the œsophagus , at 1 P.M. (fourth day), 12.*
Nausea and Vomiting.
Nausea, 7, 9.*
Some nausea (after four hours); considerable nausea (after six hours and a half), 8b.
Nausea, which passed off on eating (after fifty-five minutes), 35.
(Great nausea and vomiting, with cold sweat) , (fifth day), 42.*
(Nausea with the frontal headache), (fifth day), 42. [140.]
Nausea and dizziness, followed by heat of surface (fourth day), 40c.*
Nausea, with desire for stool (first day), 41.
Nausea and vertigo, with pain in bowels; had these symptoms four times in succession, about fifteen or twenty minutes apart, and each lasted three to five minutes (second day), .

ABDOMEN

Hypochondria.
Dull, heavy, aching pains in the region of the gall-bladder, with dull pains in the umbilical region, at 10 A.M. (third day), 12.
Pain in the region of the gall-bladder, at 8 P.M. (third day); dull pains in the region of the gall-bladder, at 8 A.M. (fourth day), 12.
Umbilicus.
Quite severe drawing pains in the umbilical region, with the headache, at 11 A.M.; frequent drawing pains in the umbilical region, at 12 M. (first day), 12.
Neuralgic pains in the right side of the umbilicus, passing down to the groin, in the evening (first day), 12.
Dull aching pains in the umbilical region, at 2 P.M. (second day); constant and severe cutting, aching pains in the umbilical region, with rumbling in the bowels, with a soft, at 10 A.M.; dull aching pains in the umbilical region, with rumbling, at 4 P.M.; with sharp, neuralgic pains in the left groin, at 5 P.M.; constant dull pain in the umbilicus, at 8 P.M. (third day); dull aching pains in the umbilicus; by spells they are very sharp and shooting, at 8 A.M. and 12 M.; with distress in the umbilical region, at 1 P.M., and with desire for stool, mushy stool, followed by an aching sensation in the rectum, at 10 P.M. (fourth day), 12.
Pain below navel (after second dose, thirty-second day), 31.
General Abdomen.
Flatulence (after four hours), 17.
Sore across the abdomen (second morning), 41. [200.]
Griping of the bowels, with considerable pain over the epigastrium (after four hours); pain in stomach and bowels much more severe (after four hours and a quarter), 17.
Pain in abdomen (first day), 41 ; (third day), 40c.
Pain in the bowels, with the nausea (second day), 41.
Pain and soreness across the abdomen, just above the pelvis , which continued all day, gradually decreasing (third day), 41.*
Pain in abdomen, as if drawn in, for half a minute, almost directly after the cramp in the stomach (second day), 33.
Slight dull pains in the bowels, in the morning (fourth day), 12.
Dull pain in the bowels, at 2 and 6 P.M. (fourth day), .

RECTUM AND ANUS

Sensation about anus as if something were crawling out or about, it, it seemed like a worm (third day), 40a.
Tenesmus and diarrhœa, copious and offensive stool, with burning of anus and pale face; tenesmus and burning before and up to the stool, but not during and after; felt better after stool (third day), 38.
At 1 P.M., while riding, was attacked with sudden and fearful tenesmus, which doubled me up in spite of all I could do; an offensive, watery stool came with a gush and great force, it came all at once, and that was the end of it; after the stool there was pain in the bowels, with ineffectual desire for stool; pains in the abdomen continued all the afternoon (fourth day), 40a.
Desire for stool woke me, with urging tenesmus, at 6.30 A.M.; stool soft, stringy and doughy, at 7.30 A.M.; another stool of about the same consistence, but not with so much tenesmus (fifth day), 40a.
(Frequent desire for stool, which is preceded and followed by cutting pain in rectum), (first and second day), 42a.
Desire for stool, with nausea; some wind passed but not much fæces (first day), 41.
Urgent desire for-stool, with no passage, but felt weak and faint (second day), 41.

STOOL

Soft papescent stool in the morning, another with pains in the umbilical region and rumbling in the bowels, at 10 A.M. (second day); mushy stool without pain (third day); natural stool, followed by aching in the rectum, at 12 M.; mushy stool, with dull pain in the umbilicus, followed by an aching sensation in the rectum, at 10 P.M. (fourth day), 12.
Three loose stringy stools, with tenesmus and burning in the anus up to stool, relieved by stool (fourth day), 33. [220.]
One loose stool (sixth day); several loose stools during the same day, with tenesmus, felt better after each stool (seventh day), 38.
Usual morning stool, but scanty and soft; at noon tenesmus, followed by loose stool, with burning of anus; stool relieves tenesmus; four stools all the same (second day); constipated (third day), 39.
Had a stool before 5 A.M., larger, softer, brighter in color prompter, and sooner after rising than usual (fifth day), 31.
Stools unusually copious, free, and lighter in color than usual (thirty-first and thirty-second mornings), 31.
Bowels move twice a day, morning and evening (before the proving); two soft stools in evening, one at 6 and the other at 7 P.M. (second day), 40.
Soft stool, discharged easily (first day); soft stool, with slight tenesmus, in the morning; during the day several soft stools, but no tenesmus (second day), 40a.
Evacuation of bowels regular, but soft and string, had to use some force to start stool from sphincter, it seemed to stick, but after passing it was doughy and stringy (first day); two soft stools after 5 P.M., which was doughy and stringy, with tenesmus, which was relieved by stool (fourth day); alternating soft and hard stool every two hours; the soft stool was doughy, stringy, and large; the hard stool was of medium size, and followed by pain (fifth day), 40b.
Stool at 9 P.M., which was doughy and hard to expel; the same again at 12 M., with tenesmus (first day); one soft stool (second day), 40c.

URINARY ORGANS

Smarting in urethra on urinating (thirty-second morning), 31.
Moderate diuresis; the same effect was also noticed in two other individuals, who experimented with it at the same time, 3d. [230.]
Average daily amount of urine 25.5 fluid ounces; sp. gr. 1024.6 (before experiment); amount 35 ounces; sp. gr. 1020 (during experiment), 8b.
Urine scanty (second day), 39.
Decreased amount of clear urine (second day), 40a.
Urine very clear (first day), 40a.
On rising in the morning, found the urine passed the night before turbid, dark, depositing a reddish sediment, and covered with a scum (thirty-second day), 31.

SEXUAL ORGANS

Pain in both testicles (second day), worse in the left, in the morning (fifth day), 40b.
At 6 P.M., pain in both testicles, worse on left side, sometimes shoots up the cord into abdomen; continued all the evening (first day), 40c.
During the proving had a severe pain in left testicle all the time (after second day), 39a.

RESPIRATORY ORGANS

In the evening had a tickling spasmodic cough coming from just above the sternum (second day), 41.
Respiration (normal, 20) 18 (after one hour); 16 (after two hours); 14 (after three hours); 12 (after four hours); 8 (after four hours and ten minutes); 6 (after four hours and a quarter), 7. [240.]
Difficulty of breathing, 11.*
Difficult respiration, with nausea (second day), 41.
Slow and difficult respiration between the vomiting spells, 34.
Breathing heavy, almost stertorous (after seven hours), 23.
When a fit of retching came on, felt as if going to be asphyxiated, 17.
Convulsive breathing, almost to suffocation (after half an hour), 24.*

CHEST

Stricture of the chest, 14.
When the vomiting ceased he complained of severe constriction about the chest, with great anguish; for ten to fifteen minutes, 34.
(Chest feels oppressed as from a heavy load), (first and second days), 42a.
Drawing pain in lower thoracic region, with nausea (first day), 41. [250.]
Pain most severe over the front of the chest, with occasional twitchings of the small intestines (after five hours), 17.
Feeling of dislocation in left side, while walking (right, left), for half an hour, in the afternoon (thirty-eighth day), 31.
(Complains of pain in left side in region of heart), (first and second days), 42a.
Throbbing in right side of chest for five minutes (twenty minutes after first dose, second day), 33.
A steady pain of some intensity about left nipple, in the afternoon (fifth day), 31.
The former pain (a steady aching) under the left nipple, but more marked than formerly (twenty-fourth evening), 31.
Pain about the spot below left nipple (after second dose, thirty-second day), 31.

HEART AND PULSE

Præcordium.
Pricking pains in the of the heart, with the headache, at 12 M. and 3 P.M. (first day), 12.
Constant burning distress in the region of the heart, at 1 P.M. (third day), 12.
Burning pain in the region of the heart, under the sternum, at 2, 3, and 6 P.M. (fourth day), 12. [260.]
Dull, hot, aching pain in the region of the heart, at 3 P.M. (fourth day), 12.
Neuralgic pains in the region of the heart and cardiac portion of the heart, at 5 P.M. (first day), 12.
Heart's Action.
(Throbbing carotids), (fifth day), 42.
Slowness of the heart's action (fourth day), 39a.
(Beats of heart slow and weak), (first and second day), 42a.
Pulse.
Pulse as frequent but softer than usual (first night), 58 standing (second night), 39.
Pulse ranged from 72 to 80, never exceeding the latter, during the proving, 40b.
Normal pulse 80; 70 and weak (fourth day); slow (seventh day), 38.
Pulse immediately rose from 63 to 71, and became much more feeble; in twenty minutes it was 60, 32.
Pulse rose at once from 74 to 80, and in five minutes fell to 70, 34. [270.]
Pulse 80 and irregular, ate 7.15 A.M.; normal (72 to 76) the remainder of the day (second day); 78, full and strong (fourth day), 60a.
Pulse 80, in the evening (first day); 78 at 7.30 A.M. (second day); 68, regular at 8 A.M.; 72, irregular and soft at 9; 80, regular at 10; 84, regular and full at 11; 83, regular and soft at 12 M.; 72, regular and full at 2 P.M.; 76, regular and full at 3 P.M.; 83 at 4.30; 82 at 6; 85 at 9 P.M.; 76, regular at 11 P.M. (third day), 40c.
Pulse 70 at 8 A.M., 85 at 11, 84 at 12, 75 at 1 P.M., 80 at 2 P.M. (fourth day), 40c.
Normal pulse, 74 to 76; 72 at 9 A.M., 68 at 12 M., 58 at 1 P.M.; 76 and full at 4.30 (first day); 90, very weak, hardly perceptible, at 9 A.M.; 72 at 12 M. (second day); normal, 74 at 7 A.M. (third day), 41.
Pulse 85 (before experiment); 1 P.M. 76; 80 at 2.10 P.M.; 74 at 2.40 P.M.; 69 at 3.15 P.M.; 66 at 3.40 P.M.; 72 at 4 P.M.; 73 at 4.30 P.M.; 67 at 5.15; 68 at 5.30 P.M.; any exertion an effort, and when forced, rapidly sending pulse up to 110, walking once or twice around the room sufficient to do this; 70 at 6 P.M.; nearly 70, down at times to 62, at 6.15 P.M.; 66 at 6.40 P.M.; 70 at 7 P.M., .

NECK AND BACK

Neck.
Neck and arms ache severely (third day), 12.
Back of neck and arms ache severely; almost impossible to hold my head up, at 1 P.M. (fourth day), 12. [300.]
Severe aching in the neck, very much worse by moving, at 2 P.M. (fourth day), 12.
Very severe aching in the back of the neck; very difficult to hold my head up, at 1 P.M. (third day), 12.
Pain in back of neck, feels as if the cords were loose (first day), 41.
Pain in middle of left neck (one hour after second dose, thirty-first day), 31.
A new pain in right sterno-mastoid near the process (twenty-fourth evening), 31.
Pain in right side of neck about middle of sterno-mastoid, and afterwards an itching in same place on the left ( ), (twenty-fourth night), 31.
Distinct pain in middle of left neck (after third dose, thirtieth day, and one hour after second dose, thirty-first day), 31.
Pain in right side of seventh vertebræ (after fourth dose, forty-fifth day), 31.
Pain in left side of neck about middle (after second dose, forty-sixth day), 31.
Back.
Back very weak (after five hours), 17. [310.]
Pain in back (half an hour after first dose, twenty-fifth day), 31.
Aching in right scapula (in bone) for ten minutes, and at the same time a dart from right clavicle to scapula (half an hour after first dose second day), 33.
For the first time had a pain on right side of dorsal spine (after second dose, thirty-second day), 31.
A long-continued, steady thrilling about an inch to left of dorsal vertebræ four inches below scapula (twenty-fourth evening), 31.
The thrilling quivering sensation about an inch from spine, and about four inches below left scapula, has been felt nearly the whole evening; it is about the size of a half-crown in extent (after third dose, thirty-first day), 31.
The thrilling in the back changed once into a severe ache, on rising from a reclining posture (after second dose, thirty-second day), .

EXTREMITIES

Hands and feet shrivelled up, as if they had been in water a long time. 13. [320.]
Feeling of clumsiness in the limbs, 1a.
Weakness and stiffness of the limbs (after half an hour), 24.
Almost entire loss of power of the gastrocnemii muscles (after two hours); all the muscles of the forearm affected in the same manner (after five hours), 3a.
Sensation of cramp in the gastrocnemii, with inability to exert them. There was no contraction in them, but they were for a time almost paralytic, lasting about an hour (after two hours, second day); repeated in the gastrocnemii and muscles of the forearm (after second dose, second day), 1.
Several times, a sensation of cramp in the gastrocnemii and muscles of the forearm. There was no contraction in them, but they were for a time almost paralytic. It seemed to affect indiscriminately those muscles that had been most affected for a short time before, being sometimes the calf of the leg, sometimes the forearm, sometimes the extensors of the knee, 1a.
Slight drawing pains in the right, elbow and calves of the legs, in the evening (first day), 12.
Pain returned above left elbow, rose to middle of humerus, and then to shoulder-joint; it was severer than last night; it then went to left instep and outside of left ankle; it also went over to right ankle ( ), (half an hour after fourth dose, second day), 31.
Pain in middle of right tibia; afterwards a dull steady pain in muscles of left thigh, and a similar pain in muscles above ridge of left scapula (after first dose, third day), 31.
Slight, transient pains in right and left knees, left tibia above inner malleolus, above left elbow, the right eye, and left trochanter major (after half an hour, twenty-third day), 31.
Momentary pains in knees and elbows, generally about the condyles (after first dose, twenty-fourth day), 31. [330.]
Pains in left instep and top of left shoulder above clavicle, and in left heel; these were transitory (after second dose, twenty-fourth day), 31.
Pain in back part of second joint of right middle finger; also in second phalanx of right great toe; had formerly similar pains in fingers and toes, but did not record them, fearing they were not reliable; for the same reason did not record pain in right pisiform bone, which returned this morning (twenty-fourth day), .

SUPERIOR EXTREMITIES

Arms ache at 11 A.M. (third day), 12.
Arms and neck ache severely at 4 P.M. (third day), 12.
Shoulder.
Slight return of the aching on top of left shoulder in muscles above the scapular ridge (twelfth night), 31.
Very slight pains in left shoulder, in the forenoon (fourteenth day and sixteenth night), 31.
Pain in upper part of left shoulder after going to bed (twenty-third night), 31.
Before going to bed noticed a pain in left shoulder, but nearer the neck than formerly (thirtieth day), 31.
Pain in left shoulder (one hour after second dose, thirty-first day), 31. [350.]
Pain in left shoulder and scapula (half an hour after fourth dose, thirty-eighth day), 31.
Slight aching in left shoulder (immediately after fourth dose, forty-sixth day), 31.
On waking had a great deal of slight shuddering in right and left shoulders in succession, and afterwards in the whole chest, extending into abdomen (twenty-fourth day), 31.
Shuddering or thrilling throughout the region of left shoulder (twenty-ninth morning), 31.
In the first half hour, had an aching pain in left humerus just above the elbow, which soon changed to the left breast about the nipple; this was very slight and transient; it then returned to the left humerus about the middle; it soon shifted to the left shoulder-joint, and was more permanent there than elsewhere; pain in shoulder-joint wens off on eating at 9 P.M. (first day), 31.
Arm.
Pain in the humerus above the elbow (twelfth and sixteenth nights), 31.
The pain in outer condyle of left humerus was protracted (twenty-fourth night), 31.
Pain in outer condyle of left humerus, in the forenoon (thirty-first day), 31.
Elbow.
While riding in omnibus had a pain in right elbow, which went up to right scapula (after second dose, second day), 31.
Felt at once a distinct transient pain at extremity of elbow (after second dose, twelfth day), .

INFERIOR EXTREMITIES

Total loss of locomotion for some hours, 23.
I went out for a walk; I had not gone far when I experienced a sense of weariness in all the muscles of progression, this feeling particularly referable to the gastrocnemius; however, I cannot altogether attribute this muscular soreness to

Veratrum , inasmuch as I had taken some active exercise on gymnastics the day before; I remained out for about an hour, and was scarcely able to get home, from muscular weakness; in a few minutes I was obliged to lie down (after three hours), 25.

Hip and Thigh.
Pain in left hip-joint, which soon went to the right , but was more severe ( left

-right), on waking (third day), 31. [370.]

On going to bed had a very sudden severe lancing pain in right hip, where the glutei are lost in the thigh (twelfth day and sixteenth night), 31.
A sudden severe ache in right trochanter (immediately after second dose, third day), 31.
Slight pain in great trochanter, in the forenoon (fourteenth day), 31.
Pain in left great trochanter and right knee, as well as left; the pains in knees were sometimes simultaneous, sometimes alternate (twenty-fourth night), 31.
Pain in right great trochanter when lying on right side; on changing to the left the pain also changed to the left great trochanter when lying on right side; on changing to the left the pain also changed to the left great trochanter (thirty-seventh night), 31.
Pain in inner condyle of let femur (one hour after second dose, third day), 31.
Knee.
Pain in tendons about left popliteal space, then in left instep; at same time pain in middle of right tibia (after first dose, third day), 32.
Woke this morning with a kind of throbbing aching in right knee, on which he was lying; on turning on left side and rubbing knee, the pain gradually went off; it then came into left knee in a milder and less steady form ( ); it then went back to the right, went off while dressing but returned and continues now; all day noticed that the pains were apt to come on while limb was in a constrained position; the pain in arm came on when holding something in the hand, and went off on setting it down (eighth day); every night (except one) has had the pain in right knee, and always while lying on right side (his usual position); it went off on turning and rubbing; slight return of pain in right knee, and in left thigh just above knee, in the evening; on going to bed frequent return of the throbbing aching in right knee, and once in the left (twelfth day), 31.
Aching in right knee, about inner condyle of femur; the pain soon extended to inner middle of thigh; the pain wanders to the front of the thigh and above the knee; the inner condyle of left femur begins to be similarly affected ( ); also the inner condyle of left humerus and instep; the pains then seemed all to settle in ankle outside (fourteenth day); pain in right knee felt on waking; this morning, slight pain in right knee and ankle (fifteenth day); above left knee (sixteenth night), .

GENERALITIES

Occasionally extreme pallor, with syncope, generally brought on from rising suddenly from the recumbent position, 27. [400.]
Tremor, 15.
She went into a spasm, with violent shrieks ; body bent backwards; arms rigid and thrown up over her head; face dark blue; breathing suspended for several seconds; lasted about two minutes; remained easier for a few minutes, and then went into another spasm, similar to the first, 13.*
Inability to control the voluntary muscles, 3.
Muscular action was not constantly interrupted, this effect occurring only after considerable exercise, as walking or jumping, 3c.
Clothes would not fit me, seemed as if they were scratching me somewhere and I could not relieve myself; constant twitching of different parts of body, trying to relieve the rubbing sensation (seventh day), 38.
My clothes did no fit well, they irritated wherever they touched; would keep twitching and it seemed almost impossible to keep still, especially when sitting (third day), 40a.
At 7 P.M. felt weak, especially in lower extremities, with heavy dull pain in head (first day), 41.
Very weak, with trembling all over, at 1 P.M. (third day), 12.
Loss of strength (after three hours and a half); general weakness (second day), 10.
Weakness throughout the body (after four hours), 8b. [410.]
Considerable fatigue of the muscles (first day), 1.
Lassitude (after three hours), 7.
A general feeling of languor and quietness; a sense of exertion on going upstairs (after thirty-five minutes); decided feeling of weakness (after five hours and a half); any exertion an effort (after six hours), 30.
Indescribable feeling of lassitude and weakness in the limbs (after six hours and a half), 8b.
Prostration, 4, 14 , etc.
Great prostration (first day), 1, 2 , etc.
Sudden prostration and vertigo, 34.
The system becomes completely relaxed, 27.
So very profound prostration was produced by it that death appeared imminent; the stimulants were poured into the patient, and on the second day he rallied, .

SKIN. [430.]

Peculiar sensation in the skin (first day), 1.
Itching in right mastoid process and inside of left thigh, at the middle (before third dose is dissolved); itching in first joint of left thumb, in left ala nasi, in left cartilage of nose, in left upper lip just under ala nasi, in left ear (after fourth dose); itching below corner of mouth (after second dose, forty-fifth day), 31.
After going to bed, had itching of right eyebrow, in right ala nasi, and in left malar prominence (twenty-fifth night), 31.
An itching which he had left several times before at the line between right ala nasi and face (sixteenth and twenty-third nights), 31.
After going to bed had the itching, first in right, then in left side of ala nasi (thirty-first day), 31.
The itching on right ala nasi was very distinct, while lying on right side, and changed to left ala when he turned over on to the left side (thirty-seventh night), 31.
Itching in left malar prominence, in orifice of left ear and left groin, in bed (first night), 31.
Itching in left malar prominence (twenty-ninth morning), 31.
After going to bed itching in left malar prominence, and about the line of the ala nasi and cheek (thirtieth day), 31.
Itching in right malar region (thirty-fourth night), 31. [440.]
Itching at once in right malar prominence (after fourth dose, thirty-eighth day), 31.
Very distinct itching and crawling in left malar prominence (at once, after first dose, forty-fourth day), 31.
Itching in left malar prominence, etc. (after second dose, forty-sixth day), 31.
Itching in left side of neck, about the middle of the sterno-mastoid (twenty-fourth night), 31.
Intense, painful itching in back of first joint of left index finger; it was precisely limited to the line of the joint, like the edge of a dissecting knife; had the feeling before in the same joint, and the corresponding joint of the finger next it, on going to bed (twenty-fourth night), 31.
After going to bed, had the itching in right ala nasi, then a stinging pain in right jugum of malar; was obliged to rub the spot, when the pain went off; afterwards felt the itching in left ala nasi (forty-fourth night), .

SLEEP

Very sleepy (third day), 38.
Somnolency, 2.
Slept but little during the night; restless (first night), 39.
Did not sleep well during the night (third night), 40b. [450.]
Slept very poorly during the night (first night), 41.
Slept well, but had frightful dreams of being on the water (first night); had a restless night; frightful dreams of people drowning (second day); sleep sound; frightful dreams of the water, as usual (third night), 12.
Dreamed of water , and had much lively dreaming, in which he was continually provoked and baffled (twelfth night), 31.
An odd dream, in which the Atlantic figured largely (nineteenth day), 31.
Dreamed about water (several nights), 31.
Much dreaming, but not of water (twenty-fifth night); a midnight much dreaming of water, fishing, etc. (twenty-sixth night), 31.

FEVER

Chilliness.
Chilliness, 3.
Chills and coldness of the body, but moisture of the skin, 2.
A shuddering, twice during the night, towards morning (fourteenth night), 31.
After five hours, attacked by one or two cold shivers. My hands and feet became cold and benumbed, though there was a large fire blazing in the grate.
The cold numb feeling crept up my legs and arms, and at last my whole body felt as if enveloped in cold damp clothing, and I became quite prostrate, 17. [460.]
During the greatest depression he complained of being very cold, and his limbs were bathed with a cold perspiration, 34.
General coldness of the body (after three hours and a half), 10, 39a.
Felt cold in the morning, after being up half an hour (third day), 38.
Skin cold, and covered with a profuse clammy sweat, 11.
Skin cool (first day), 1.
Cold extremities, 4, 23, 25.
Extremities cold as far as the elbows and knees (after half an hour), 24.
At 6 P.M., feet and hands cold, with frontal headache (second day), 41.
Hands and feet cold, 13.
Feet cold and chilly, with pressing pain eyes (first day), 41.
Heat. [470.]
Slight heat of body and cold sweat of forehead (first day), 41.
Heat of the surface followed the dizziness and nausea; icy coldness followed the heat (fourth day), 40c.
Skin of head hot and moist (second day), 41.
Sweat.
General perspiration, 10.
Profuse diaphoresis and sense of utter prostration (after third dose), 7.*
Colliquative sweats, 4.
Free perspiration and cool surface, 27.*
(Cold sweat with the vomiting), (first and second days), .

CONDITIONS

Aggravation.
( Morning ), On rising, vertigo; photophobia; on waking, most symptoms.
( Evening ), Most symptoms.
( Lying down ), Headache.
( Motion ), Headache; tearing pain in stomach; aching in neck.
( Noise ), Headache.
( Stooping ), Heavy feeling over left eye.
Amelioration.
( Bending forward ), Cramp in stomach.
( Closing eyes ), Vertigo and photophobia.

SUPPLEMENT: VERATRUM VIRIDE. Authority.

43 , T. S. Scales, Pub. Mass. Hom. Med. Soc., vol. iv, 283.

A man, fifty years old, had compound fracture of humerus; for a week or two his arm did well, and was rapidly recovering, while his general health continued perfectly good; his doctor gave him a heroic dose of Verat. vir. "to see what it would do for him."
Soon the patient was seized with rigors, prostration, a feeling of terrible coldness, and soon mortification of the injured limb, followed by death in a few hours, 43.

VERATRUM VIRIDE.